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20 January 2009, Volume 36 Issue 1 Previous Issue    Next Issue

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Correlation study of pericoronitis and position of mandibular wisdom tooth HE Wei1, XIE Wen-yang1, LIU Xia-cheng2 Inter J Stomatol. 2009, 36 (1):  1-1～3.  Abstract ( 1973 )   HTML ( 7 )   PDF（pc） (115KB) ( 1169 )   Save Objective To study the relationship between the position of mandibular wisdom tooth and pericoronitis. Methods 450 mandibular wisdom teeth of 434 patients were collected and studied. 450 mandibular wisdom teeth were divided into two groups. One was pericoronitis group（groupⅠ）, the other was no pericoronitis group（groupⅡ）. Impacted type of mandibular wisdom tooth, the depth of pericoronal pockets and the size of gingival flaps, the height and gradient of retromolar pads were recorded. The data in the two groups was analysis statistically. Results Compared with the mandibular wisdom tooth in the no pericoronitis group, the retromolar pad was higher and more oblique, pericoronal pocket was deeper and size of gingival flap was bigger in the pericoronitis group. But no difference was observed in type of impaction between two groups. Conclusion It was the danger factors of pericoronitis occurrence that deeper pericoronal pocket and bigger gingival flap surrounding mandibular wisdom tooth, heighter and more oblique retromolar pad, which was served as the criterion of prophylactic wisdom tooth extraction. Related Articles | Metrics

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Application and understanding of the effectiveness of Huaxi unilateral cleft lip GUO Xue -song, TIAN Yu Inter J Stomatol. 2009, 36 (1):  4-4～5.  Abstract ( 1536 )   HTML ( 4 )   PDF（pc） (96KB) ( 962 )   Save Objective To evaluate the effectiveness of Huaxi unilateral cleft lip repair. Methods Huaxi unilateral cleft lip repair was applied for the repair of unilateral cleft lip in 49 cases. The operations were conduced according to the designs and the secondary nasal deformities were corrected at the same time. The effects were evaluated one week after operation. Results Skin flaps near the floor of nose were necrosis partly in 2 cases. 47 cases showed wound healing well. In dynamic and static state, the effects of the operations were satisfactory. Conclusion The Huaxi unilateral cleft lip repair is feasible for unilateral cleft lip repair. Related Articles | Metrics

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Clinical application of buccal path in removal of horizontal impacted mandibular SHEN Hai-ping, ZHUANG Hao. Inter J Stomatol. 2009, 36 (1):  6-6～7.  Abstract ( 1492 )   HTML ( 4 )   PDF（pc） (104KB) ( 1099 )   Save Objective To investigate the application of buccal path in removal of horizontal impacted mandibularthird molars. Methods 57 cases of moderate-low horizontal impacted mandibular third molars were removed by buccal path. Results 1）All cases were removed by buccal path. 2）Surgical field of buccal path was large and clear exposure, removal bone was sufficient, cut-off crown of tooth was quick. 3）Complication of buccal pathwas few. Conclusion Buccal path was suited to extract impacted mandibular third molar of moderate-low horizontal position. Related Articles | Metrics

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Expression and significance of twist gene in human ameloblastoma GUO Hua1, ZHOU Yin -mei1, TANG Xiu-fa2, HUA Cheng-ge2, WANG Si-hua1. Inter J Stomatol. 2009, 36 (1):  9-9～11,125.  Abstract ( 1413 )   HTML ( 5 )   PDF（pc） (4698KB) ( 843 )   Save Objective To investigate the expression and clinicopathological significance of transcription factorTwist in human ameloblastoma（AME） and radicular cyst tissues. Methods Immunohistochemistry was used to detect the expression of the Twist in 40 cases of ameloblastoma tissue and 10 cases of radicular cyst tissue. Meanwhile, the Twist protein were detected in 5 cases of ameloblastoma and 1 case of radicular cyst tissue by Western blot. And the expression differences and clinicopathological significances of the Twist were analyzed. Results The positive expression rate of Twist in ameloblastoma tissues was 75.0%, which was significantly higher than that in radicular cyst tissues（20.0%, P<0.05）. Compared with in radicular cyst tissues, the protein expression of Twist were up-regulated in AME. Conclusion Twist has an inappropriate expression in ameloblastoma and it may play an important role in the tumorigenesis and progression of AME. Related Articles | Metrics

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Study of marginal bone loss around implant and clinical evaluation about one year DENG Yue1, WANG Wan-chun1, ZHAO Jun1, Kim Young-gyu2, Kwon Jong-jin2. Inter J Stomatol. 2009, 36 (1):  12-12～15.  Abstract ( 1510 )   HTML ( 5 )   PDF（pc） (143KB) ( 1386 )   Save Objective To access the clinical survival and marginal bone loss around implant after immediate loading and investigate related factors. Methods Total of 171 implants were placed in 75 patients, including 110 ITI implants and 61 Osstem SSⅡ implants. All implants were immediately loaded in 24 hours and final prosthetics were placed in 6 months. Radiologic examinations were taken at post-operation, and measured the marginal bone level around implants after 6 months and 12 months. Results Clinical survival was 100% in ITI implants and 98.4% in Osstem SSⅡ implants. Main marginal bone loss was observed in 6 months after immediate loading. There was no difference in maxilla, but there was significant difference in bone level post-operation and bone resorption in 6 months in mandible between two systems. From 6 to 12 months, the more bone resorption was observed in single crown group. Conclusion The clinical survival is acceptable in immediate loading procedure if the implant had excellent primary stability and equal occlusion. The marginal bone loss is dependent on the position of polished-rough junction of one-stage implant. Related Articles | Metrics

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The comparative study of the treatment of Angle class Ⅱ division 1 malocclusion SHI Jian-lu, LIN Yi-hui. Inter J Stomatol. 2009, 36 (1):  16-16～20.  Abstract ( 1471 )   HTML ( 5 )   PDF（pc） (209KB) ( 1163 )   Save Objective The purpose of this study was to evaluate curative efficacy of micro-implant anchorage（MIA） and headgear anchorage（HGA） with MBT straight wire appliance in the treatment of class II division 1 malocclusion patients. Methods The study was performed on 40 selected adults making use of MBT with MIA（group A） and with HGA（group B）. We examined the cephalometric and model analysis before and after treatment and compared the curative effect between group A and B. Results 1）There are significant curative changes in group A and B, such as the overjet, over bite and the position of incisors. These differences have statistic significance. 2）The curative effects are different between group A and B. Except for the Li-E（mm）, most of the values such as SNA（°）, U1-SN（°）, U1-PP（mm）, U6-Ptm（mm）, and OJ（mm） displayed more effective results in group A, and all the differences had statistic meanings. 3）The average period of treatment is shorter in group A（13 months） than in group B（19 months）. 4）In group A, the MIA is less shifted both in the sagittal and vertical direction. And it is kept stabilization under orthodontic force. Conclusion The better curative efficacy could be get both in the group A and B. There were not only shorter periods of treatment but also better curative effect in the group A than group B. Related Articles | Metrics

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The second orthodontic treatment for adult patients with Angle class Ⅱ division JIANG Shi-tong, XU Chong-kai, LIU Hong-jie, JIAO Guang-jun, AN Zhong-jun, JIANG Liang. Inter J Stomatol. 2009, 36 (1):  21-21～22,26.  Abstract ( 1649 )   HTML ( 7 )   PDF（pc） (4700KB) ( 1529 )   Save Objective To explore the reason for the first orthodontic failure of adult patients with Angle class Ⅱ division 1 malocclusion and to seek a successful method of the second orthodontic treatment. Methods Authors achieve a good outcome of the second orthodontic treatment for failure of the 8 cases of adult patients with Angle class Ⅱ division 1 malocclusion, with the methods of retreating moved forward molars with face bow and implanting anchorage, controlling molar rout, up righting molar axis and so on. Results The second orthodontic treatment of 8 cases of adult patients all attained the expected aim. Conclusion The mainly reason for the first orthodontic failure is the failure to control molar anchorage. The free application to face bow and implanting anchorage can renew the lost molar anchorage. Related Articles | Metrics

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In vitro study of oral Saccharomyces albicans in adhesion from human immunodefici CHEN Chang-rong1, CHEN Jian-gang2 Inter J Stomatol. 2009, 36 (1):  23-23～26.  Abstract ( 1672 )   HTML ( 4 )   PDF（pc） (157KB) ( 1030 )   Save Objective To discuss the reason from which oral cavity Saccharomyces albicans get sick for being infected from the angle of looking at the human immunodeficiency virus（HIV）-infected persons and analyzing the saliva secreted immunoglobulin A（sIgA） content and the Saccharomyces albicans adherency change rates. Methods To exam saliva sIgA content, to observe the Saccharomyces albicans standard and clinical separation in content of sIgA that is not contained in the sIgA environment and the buccal mucosa epithelial cell adherency rate by the sticky experiment, and to compare the differences of oral cavity Saccharomyces albicans adherency rate between HIV/acquired immunodeficiency syndrome（AIDS） group and healthy control group. Results The sIgA content in HIV/AIDS group is lower than that of the healthy group（P＜0.05）. In the environment of sIgA content, the ensemble average of Saccharomyces albicans stick rate（standard and clinical separation） is lower than that of the non-sIgA environment, and therefore the differences between the two groups do have the statistics significance（P=0.001）. In the environment of sIgA content, Saccharomyces albicans adherency rate in the oral cavity of the HIV/AIDS group is higher than that of the healthy control group（P＜0.005）. Conclusion The saliva sIgA content change and the Saccharomyces albicans adherency change in the HIV/AIDS group easily infected by the oral candidiasis are interdependent and their relationship is rather close. Related Articles | Metrics

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Three-year clinical application of light cure Beautifil flowable polymeric restor GUO Yu-feng1, MEI Yu-xin2 Inter J Stomatol. 2009, 36 (1):  27-27～29.  Abstract ( 1414 )   HTML ( 6 )   PDF（pc） (120KB) ( 1129 )   Save Objective To evaluate the clinical effect of light cure Beautifil flowable（LCBF） in molar occlusal pit and fissure. Methods 720 the first up and down permanent molars in 360 patients aged from 6-10 years were treated with LCBF in occlusal pit and fissure. The opposite permanent teeth were treated with light cure pit and fissure sealant LCFS as the controls. The patients were followed up for 3 years. Results The remain rate（%） of LCBF sealant after 1, 2 and 3 years was 93.86%, 84.58% and 79.72% respectively. It was higher than that of LCFS（P＜0.01）. The incidence rate（%） of caries in LCBF treated teeth was 0, 0.15% and 0.87%, and lower than that of the controls（P＜0.05）. Conclusion Beautifil flowable can be used as pit and fissure sealant to prevent caries. Related Articles | Metrics

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Initial exploring of clinical effect of the application of Koukuining capsules in LIU Jian-fang1, ZHAO Fu-hu2, LIU Li-chun3 Inter J Stomatol. 2009, 36 (1):  30-30～31.  Abstract ( 1690 )   HTML ( 8 )   PDF（pc） (82KB) ( 1164 )   Save Objective To primarily study the efficiency of Koukuining capsules in the treatment of recurrent aphthas ulcer. Methods Koukuining capsules were made of Si-ni soup and chrysanthemum, and it was used to treat 75 recurrent aphthas ulcer cases. Results The efficiency of Koukuining capsules in the treatment of recurrent aphthas ulcer was 100%. Conclusion Koukuining capsules are effective in the treatment of recurrent aphthas ulcer, and further studies are still needed to validate this conclusion. Related Articles | Metrics

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Bacteriocins produced by caries-related bacteria LI Li, ZHOU Xue-dong Inter J Stomatol. 2009, 36 (1):  32-32～34,37.  Abstract ( 1409 )   HTML ( 5 )   PDF（pc） (141KB) ( 603 )   Save Bacteriocins are directly produced as ribosomally synthesized protein, polypeptides or precursor polypeptides. The bacteriocins produced by caries-related bacteria may be related to the colonization, adhesion and other cariogenic characters of the bacteria. This review describes the bacteriocins produced by caries-related bacteria, focusing on the reseach progress in mutacin, lactobacillin, sanguicin et al. Related Articles | Metrics

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A new root canal irrigant: MTAD ZHU Wen-hao, WANG Shi-ming Inter J Stomatol. 2009, 36 (1):  35-35～37.  Abstract ( 1575 )   HTML ( 17 )   PDF（pc） (103KB) ( 940 )   Save Root canal irrigation, accompanying with instrument preparation, is an important procedure during root canal preparation process. Rinse solution should be able to dissolve necrotic tissue, have sterilization and bactericidal action, and remove smear layer. This paper will introduce a new root canal irrigant: MTAD（a mixture of tetracycline isomer, acid, and detergent）. It can remove smear layer effectively, have antimicrobial efficiency and less cytotoxicity, and be used securely in clinical therapy. Related Articles | Metrics

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The study on the orthodontic treatment related to temporomandibular disorder WANG Jing, WANG Sheng,LAI Wen-li. Inter J Stomatol. 2009, 36 (1):  38-38～40.  Abstract ( 1849 )   HTML ( 12 )   PDF（pc） (100KB) ( 1112 )   Save Temporomandibular disorder（TMD） is a common disease in dental clinical. It is generally accepted that TMD is a disorder and retrogression of masticatory muscles and temporomandibular joint due to many factors. The possible relationship between orthodontic treatment and temporomandibular disorder is a topic of great interest. In current decades, more and more researches have been focused on this field. This is a review about the study of their relationship. Related Articles | Metrics

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Current development of the treatment about adenoid cystic carcinoma in salivary g YAN Bing, LI Long-jiang Inter J Stomatol. 2009, 36 (1):  41-41～42，45.  Abstract ( 1313 )   HTML ( 6 )   PDF（pc） (108KB) ( 957 )   Save Adenoid cystic carcinoma（ACC） is one of the common malignant tumors in oral and maxillofacial salivary glands. Nowadays, the main treatment of ACC is radical surgery combined with postoperative radiation therapy. However, there is an incomplete control of local recurrence and distant metastasis. This article summarizes some information about the current development of the treatment of ACC in chemotherapy, radiotherapy and genetic and molecular therapy through reviewing the lately corrective literatures, in order to improve clinical treatment of ACC. Related Articles | Metrics

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The progress in the diagnosis and treatment of panfacial fracture LI Ming-heng, LIU Lei Inter J Stomatol. 2009, 36 (1):  43-43～45.  Abstract ( 1458 )   HTML ( 3 )   PDF（pc） (103KB) ( 746 )   Save Panfacial fracture is definited as the fracture which happened in the middle and lower face at the same time. Jaw bones maintain the profile of face. If panfacial fracture happens, the profile of face will be destroyed and some systemic complications such as craniocerebral injury, organ injury and limb injury will appear sometimes. Therefore, panfacial fracture is always the focus of trauma surgeons. There still have been many disputes in the diagnosis and treatment of panfacial fracture. This article reviewed the dispute and progress in the diagnosis and treatment of panfacial fracture. Related Articles | Metrics

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Advances in treatment of salivary gland malignant tumor XIA Yong, NONG Xiao-lin Inter J Stomatol. 2009, 36 (1):  46-46～49.  Abstract ( 1442 )   HTML ( 3 )   PDF（pc） (133KB) ( 1657 )   Save Salivary gland malignant tumor is a significant malignant tumor of oral maxillofacial region with high incidence rate. There is no significant difference in sex incidence and age incidence of salivary gland malignant tumor. The salivary gland malignant tumor which mostly originates from salivary gland epithelial tissue may occur in large salivary glands such as parotid gland, submaxillary gland, sublingual gland and minor salivary glands like palate gland and so on. These tumors have features of complicated tissue typing and cell component. With some research progress in treatment of salivary gland malignant tumor in recent years, the treatment which becomes the focus on surgery, radiotherapy, chemotherapy and biotherapy and so on, is reviewed here. Related Articles | Metrics

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Severe head injury and pseudoankylosis of temporomandibular joint KUANG Jin, LONG Xing Inter J Stomatol. 2009, 36 (1):  50-50～51.  Abstract ( 1306 )   HTML ( 3 )   PDF（pc） (80KB) ( 671 )   Save Intracranial hematoma and intracranial hypertension are common after severe head injury. Then craniotomy is needed to perform in time. Among the operational approaches, pterional craniotomy for its advantage to expose the skull base and saddle area is usually selected, however, inappropriate dissection of the temporal muscle often induce postoperationive muscle atrophy, and mouth opening limited. This article reviews the postoperationive pseudoankylosis after severe head injury. Related Articles | Metrics

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The research progress of adaptive growth remodeling of mandibular condyle to biom XUT ing, LIN Xin-ping, GU Zhi-yuan Inter J Stomatol. 2009, 36 (1):  52-52～54.  Abstract ( 1366 )   HTML ( 3 )   PDF（pc） (110KB) ( 825 )   Save The mandibular condyle, which influences directly the morphology and function of mandible, is one of the major growth and development sites of the face. The condylar cartilage which covers on the surface of the temporomandibular joint is the fundament for keeping remodeling when biomechanical force is applied on it. The condylar chondrocyte is constantly the focus in craniofacial development and functional orthopedic researches. This is a review of the recent research progress in adaptive remodeling of mandibular condyle to biomechanical force. Related Articles | Metrics

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Research progress of maxillofacial space infection ZHANG Chun-xu, LIANG Xin-hua Inter J Stomatol. 2009, 36 (1):  55-55～57.  Abstract ( 1426 )   HTML ( 4 )   PDF（pc） (104KB) ( 997 )   Save Maxillofacial space infection occurs commonly in the maxillofacial region. Infections can spread along these underlying fascial spaces causing multiple spaces infection with life threatening complications. This article reviews the research progress in the aspects of diffusion path, microbiology, treatment of maxillofacial space infection. Related Articles | Metrics

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Isotope bone scan for diagnosis and treatment of unilateral condylar hyperplasia< CHEN Yu-xiang, LONG Xing Inter J Stomatol. 2009, 36 (1):  58-58～60.  Abstract ( 1509 )   HTML ( 4 )   PDF（pc） (106KB) ( 812 )   Save Algorithm for the treatment of unilateral condylar hyperplasia（UCH） is based on the assessments of the growing of the condyle. Isotope bone scan is as a new assessment way which contains two mainly ways of planar imagine scintigraphy and single photon emission computed tomography, and no dubiety superior to the clinical and traditional radiological way in the diagnosis and planning of treatment of UCH. Thus, many scientists and clinical surgeons have been doing many research on isotope bone scan technique of its mechanism, different assessment ways, and their applying to the assessments of the growing of the condyle in the diagnosis and planning of treatment of UCH, how they work up and also their advantage and disadvantage compared to the clinical way and each other. This article is introducing the new findings and results in recent years. Related Articles | Metrics

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Advanced study of tissue engineering of mandibular condyle ZHENG You-hua, ZHANG Zhi-guang Inter J Stomatol. 2009, 36 (1):  61-61～63.  Abstract ( 1309 )   HTML ( 4 )   PDF（pc） (108KB) ( 653 )   Save Osteoarthrosis or osteochondral tissue destroy of mandibular condyle are common diseases clinically. Tissue engineering provides a new way and the revolutionary possibility for curing these diseases. Although characterization of the mandibular condyle has been extensively studied, tissue engineering of the mandibular condyle is still in an early stage. This review focuses on advanced study relevant to cell sources, scaffolds, tissue engineering regeneration and challenges for mandibular condyle tissue engineering Related Articles | Metrics

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Progress on effects of Notch signal pathway in tooth germ development and dental MA Liang, WANG Sheng-chao, ZHANG Ya-qing Inter J Stomatol. 2009, 36 (1):  64-64～68.  Abstract ( 1367 )   HTML ( 3 )   PDF（pc） (150KB) ( 813 )   Save Notch signaling is a highly conserved mechanism throughout evolution. It controls cell proliferation, differentiation, apoptosis through interaction of cells, then determines the cell fate during multicellular development. In this review, the roles of Notch signaling involved in the tooth development and dental repair after injury were discussed. Related Articles | Metrics

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Focal osteoporotic bone marrow defect of the jaw XIE Xiao-yan, ZHANG Zu-yan Inter J Stomatol. 2009, 36 (1):  69-69～70,74.  Abstract ( 1416 )   HTML ( 4 )   PDF（pc） (105KB) ( 895 )   Save Focal osteoporotic bone marrow defect（FOBMD） of the jaw, most commonly seen in the posterior mandible of middle-aged women, is a radiolucent lesion. Yet, the pathogenesis of FOBMD is unknown. The lesion, usually asymptomatic, is only incidentally discovered through radiography. Since FOBMD is infrequency, it is difficult to get the initial clinical diagnosis. In this article, we reviewed the pathogenesis, clinical characteristic, radiographic exhibition, histologic feature, diagnosis and treatment of the FOBMD to get some information for improving the ability of recognition in clinic. Related Articles | Metrics

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Tumor supressor genes and expressions in carcinoma of tongue WAN Chang-qing, LIAO Gui-qing Inter J Stomatol. 2009, 36 (1):  71-71～74.  Abstract ( 1471 )   HTML ( 3 )   PDF（pc） (137KB) ( 974 )   Save The development of tongue carcinoma has series accumulated changes of many tumor suppressor genes. Simultaneously, these gene expressions have changed too. The investigation of these tumor suppressor genes and the changed expressions of tumor supressor gene proteins are significantly contributed to the effect of clinical therapy. This article focused on the investigated advancement of these tumor supressor genes and expressions in squamous cell carcinoma of the tongue. Related Articles | Metrics

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Microdialysis and its application in stomatology WANG Lin, LIAO Gui-qing Inter J Stomatol. 2009, 36 (1):  75-75～77.  Abstract ( 1213 )   HTML ( 3 )   PDF（pc） (106KB) ( 850 )   Save Microdialysis technique, developed recently, is a method used to obtain biochemical samples from the extracellular fluid of live tissues. It has been performed widely in biomedical field. The principles, features, samples of microdialysis and its application in stomatology were introduced in this review. Related Articles | Metrics

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Progress of correlation between CD40/CD40L and interleukin-8 and monocyte chemota LI Nan-nan, ZHANG Zhi-min, WANG Jin-rui, GAO Wen-xin Inter J Stomatol. 2009, 36 (1):  78-78～80.  Abstract ( 1478 )   HTML ( 3 )   PDF（pc） (120KB) ( 1372 )   Save The interaction of CD40/CD40L can promote the production of many proinflammatory cytokine and chemokine, such as interleukin（IL）-8 and monocyte chemotactic protein（MCP）-1, which can cause the accumulation of inflammatory cells to the sites, in order to regulate the generation and development of inflammation. This article is a review about the correlation between CD40/CD40L and IL-8, MCP-1 and regulate factors in which CD40/CD40L induce IL-8, MCP-1. Related Articles | Metrics

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Pathogenesis of Ciclosporin-induced gingival epithelial hyperplasia LIU Pei-hong, MA Su Inter J Stomatol. 2009, 36 (1):  81-81～83.  Abstract ( 1500 )   HTML ( 2 )   PDF（pc） (109KB) ( 1037 )   Save Drug-induced gingival overgrowth（DGO） is one of the gingival diseases because of suming immune depressant, calcium channel blocker and anti-epileptic drug. DGO was defined to gingival fibroplasia and enlargement in tradition. It was discovered that the gingival epithelial thickening was one of the important reasons of causing DGO recently. So the review on pathogenesis of Ciclosporin-inhibited gingival epithelial apoptosis and Ciclosporin-accelerated gingival epithelial proliferation was made. Related Articles | Metrics

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Research advance of Nifedipine induced gingival hyperplasia WEN Hai-yan, SHU Rong Inter J Stomatol. 2009, 36 (1):  84-84～87.  Abstract ( 1789 )   HTML ( 4 )   PDF（pc） (152KB) ( 986 )   Save Drug-induced gingival hyperplasia is a common periodontal disease in the clinic. Nifedipine is the first generation of the calcium channel blockers. Drug-induced gingival hyperplasia is one side effect of the Nifedipine. In the Nifedipine induced gingival hyperplasia, apoptosis-related regulator gene B cell Iymphoma/leukmia（bcl）-2, c-myc, and transcription factor forkhead box（Fox） all play important roles in the process of inhibiting cell apoptosis. The heterogeneity of fibroblast expressed complement receptors is related to the mechanism of the drug-induced gingival hyperplasia. The role of inflammatory cytokines and adhesion molecules in drug-induced gingival hyperplasia should not be overlooked. This article wil1 review the latest researches on the nifedipine induced gingival hyperplasia. Related Articles | Metrics

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Recent advances in cultured approaches of cranial neural crest stem cells YANG Rong, JIANG Hong-bing Inter J Stomatol. 2009, 36 (1):  88-88～90.  Abstract ( 1184 )   HTML ( 3 )   PDF（pc） (113KB) ( 1154 )   Save The vertebrate cranial neural crest is a pluripotent stem cell population, giving rise to various types of tissues in the craniofacial region. This article is to review the research progress of in vitro culture approaches of cranial neural crest stem cells, to provide methodological reference for study on craniofacial development, regeneration, and associated diseases. Related Articles | Metrics

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Progresses on the genetic study of 22q11 deletion syndrome FANG Shao-wei, ZHENG Qian Inter J Stomatol. 2009, 36 (1):  91-91～93.  Abstract ( 1419 )   HTML ( 9 )   PDF（pc） (110KB) ( 1902 )   Save 22q11 deletion syndrome is a genetic disease which expresses the micro deletion of the 22q11.2. Its appearance involves multitude organics and contains many syndromes which have different phenotype on the genetics, as the research going on, the main research point is the minimal DiGeorge critical region, which is consist of tbx-1, hira, UFD1L, pcqap and so on. The research method is maturing, which includes five ways. This review tries to introduction of the research progresses of the currant study and provides the reference for other researchers. Related Articles | Metrics

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Role of small ubiquitin like modifier in etiology of nonsyndromic cleft lip and p LIAO Li-shu, MENG Tian, ZHENG Qian, SHI Bing Inter J Stomatol. 2009, 36 (1):  94-94～97.  Abstract ( 1782 )   HTML ( 3 )   PDF（pc） (145KB) ( 955 )   Save According to the proteomics, post-translational modification of proteins by small ubiquitin like modifier（SUMO） have many and variable consequences and have a key role in regulating and expanding the diversity of function in the proteome. A family member of SUMO, SUMO-1 participated most of the post-translational modification of proteins related to cleft lip and palate. Related Articles | Metrics

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Dentin matrix protein-1 and biomineralization LIU Dong-mei1, DONG Fu-sheng2 Inter J Stomatol. 2009, 36 (1):  98-98～101.  Abstract ( 1497 )   HTML ( 4 )   PDF（pc） (133KB) ( 1673 )   Save Dentin matrix protein（DMP）-1 is an acidic non-collagenous protein that is necessary for the proper biomineralization of bone, cartilage, cementum, dentin and enamel. Protein chemistry studies have shown that the full length of DMP-1, as a precursor, is cleaved into two distinct forms: the C-terminal and N-terminal fragments. DMP-1 is believed to have multiple functions in vivo, acting both as a signaling molecule and a regulator of biomineralization and is essential in the maturation of odontoblasts and osteoblasts. This article reviewed the role of DMP-1 in gene regulation, tissue/cell expression patterns, and biominerealized functions in dentinogenesis and osteogenesis. Related Articles | Metrics

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Bone morphogenetic protein-2 and epithelial tumor YE Ming-fu, ZHENG You-hua Inter J Stomatol. 2009, 36 (1):  102-102～104.  Abstract ( 1496 )   HTML ( 2 )   PDF（pc） (109KB) ( 1171 )   Save Previous studies have indicated the close relation between bone tumors and bone morphogenetic protein-2（BMP-2）. As the knowledge of tumorigenesis mechanism being more profound and extensive, scientists have focused on the correlation between epithelial tumors and BMP-2. Thus, this review will overview the biological characteristics of BMP-2, mechanism of BMP-2 signaling pathway, the expression of BMP-2 in tumors, the relationships between BMP-2 and angiogenesis in tumors, tumors growth, tumors invasiveness, the potential application of BMP-2 and related drugs in tumor therapy. Related Articles | Metrics

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Reporter gene and its application in tooth development and tooth regeneration WANG Jin-ming, LING Jun-qi Inter J Stomatol. 2009, 36 (1):  105-105～107.  Abstract ( 1336 )   HTML ( 4 )   PDF（pc） (106KB) ( 742 )   Save Reporter gene whose expression is easily detectable and therefore is used to report the expression and regulation of target gene. A multiplicity of reporter genes can be applied to diverse fields according to different purpose. As an effective technology, reporter gene has been used extensively in the studies of tooth development and tooth regeneration. It was helpful in studying the regulation and expression of genes, controlling study of transfection, as well as differentiation and orientation of cells. And it becomes a valuable tool in studies of mocular basis in tooth development which will provide foundamental knowledge to regeneration of tooth. Related Articles | Metrics

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Relationship between extracellular matrix metalloprotease inducer and malignant t HUANG Zhi-quan1, HUANG Hong-zhang2 Inter J Stomatol. 2009, 36 (1):  108-108～110.  Abstract ( 1400 )   HTML ( 3 )   PDF（pc） (138KB) ( 896 )   Save The expression of extracellular matrix metalloprotease inducer（EMMPRIN） raises significantly in many malignant tumors. Many studies have shown that EMMPRIN can facilitate the invasion of malignant tumours via stimulating matrix metalloprotease（MMP）production and play an important role in growth, invasion, metastasia and malignant potential of tumors. The advanced research about action mechanism and regulation of EMMPRIN, as well as relationship between EMMPRIN and oral and maxillofacial tumors, will be reviewed in this article. Related Articles | Metrics

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Factors and diagnosis of root resorption following orthodontic treatment ZUO Zhi-gang, HU Min Inter J Stomatol. 2009, 36 (1):  111-111～113.  Abstract ( 1643 )   HTML ( 4 )   PDF（pc） (98KB) ( 1088 )   Save Root resorption is one of the common complications in orthodontic treatment. The influencing factors and the mechanism of root resorption following orthodontic treatment are uncertained. This article summarized most of influencing factors including both biological factors and mechanical factors. Some diagnosis methods and assessment methods are reviewed. Related Articles | Metrics

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Evaluation of oral microbial diversity with denaturing gradient gel lectrophoresi GU Hai -jing, LING Jun-qi Inter J Stomatol. 2009, 36 (1):  114-114～116.  Abstract ( 1628 )   HTML ( 3 )   PDF（pc） (111KB) ( 1039 )   Save Denaturing gradient gel electrophoresis（DGGE） is an advanced molecular fingerprinting technique. Because of its objective, rapid and accurate ssessment character, DGGE has extensively been used on assessment of the diversity and changes of bacterial species in the microbial population. This article reviewed the principle, merits and limitations of DGGE technique and also reviewed the latest research in the oral cavity with this novel technique. Related Articles | Metrics

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Limitations and the reasons for the bottleneck analysis of bone tissue engineerin YAN Xiang-zhen, YANG Pi-shan Inter J Stomatol. 2009, 36 (1):  117-117～119.  Abstract ( 1485 )   HTML ( 4 )   PDF（pc） (100KB) ( 751 )   Save Recently, great progress in the bone tissue engineering has been aquired, however, various basic problems have to be solved before clinical application. The major drawbacks are the difference of function and behavior between osteoblasts in culture and their counterparts in vivo, deficiencies in bone-forming ability, and the large gap between tissue-engineered bones and the natural physiological bones. The reasons are probably that the microenvironment of cultivation is not perfect enough, engineered bone can not achieve the synchronization of vascularization and neurotization, and construction of the complex of tissue-engineered bone and periosteum is still lack of research. Related Articles | Metrics

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Research progress in the genes and proteins of hypohidrosis ectodermal dysplasia< LEI Ke, HE Xiang-yi Inter J Stomatol. 2009, 36 (1):  120-120～122.  Abstract ( 1470 )   HTML ( 6 )   Save Hypohidrosis ectodermal dysplasia（HED） is a rare congenital disorder that results in abnormalities in the structures of ectodermal origin tissues, such as teeth, eccrine sweat glands, hair and nails. However, most of studys in HED is presented in the form of clinic case reports. This article reviews the research progress of HED in types, genetic locations, proteins, and signaling pathways in odontogenesis. Related Articles | Metrics