Abstract: 22q11 deletion syndrome is a genetic disease which expresses the micro deletion of the 22q11.2. Its appearance involves multitude organics and contains many syndromes which have different phenotype on the genetics,
as the research going on, the main research point is the minimal DiGeorge critical region, which is consist of tbx-1, hira, UFD1L, pcqap and so on. The research method is maturing, which includes five ways. This review tries to introduction of the research progresses of the currant study and provides the reference for other researchers.