Abstract: Drug-induced gingival hyperplasia is a common periodontal disease in the clinic. Nifedipine is the first generation of the calcium channel blockers. Drug-induced gingival hyperplasia is one side effect of the Nifedipine. In the Nifedipine induced gingival hyperplasia, apoptosis-related regulator gene B cell Iymphoma/leukmia（bcl）-2, c-myc, and transcription factor forkhead box（Fox） all play important roles in the process of inhibiting cell apoptosis. The heterogeneity of fibroblast expressed complement receptors is related to the mechanism of the drug-induced gingival hyperplasia. The role of inflammatory cytokines and adhesion molecules in drug-induced gingival hyperplasia should not be overlooked. This article wil1 review the latest researches on the nifedipine induced gingival hyperplasia.