Abstract: The expression of extracellular matrix metalloprotease inducer（EMMPRIN） raises significantly in many malignant tumors. Many studies have shown that EMMPRIN can facilitate the invasion of malignant tumours via stimulating matrix metalloprotease（MMP）production and play an important role in growth, invasion, metastasia and malignant potential of tumors. The advanced research about action mechanism and regulation of EMMPRIN, as well as relationship between EMMPRIN and oral and maxillofacial tumors, will be reviewed in this article.