ameloblastoma, Twist, epithelial-mesenchymal transition, transcription factor,"/> <font face="Verdana">Expression and significance of twist gene in human ameloblastoma</font>
Int J Stomatol

Inter J Stomatol ›› 2009, Vol. 36 ›› Issue (1): 9-9～11,125.

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Expression and significance of twist gene in human ameloblastoma

GUO Hua1, ZHOU Yin -mei1, TANG Xiu-fa2, HUA Cheng-ge2, WANG Si-hua1.   

  1. 1. State Key Laboratory of Oral Diseases, Sichuan University, Chengdu 610041, China; 2. Dept. of Head and Neck Tumor Surgery, West China College of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2008-06-17 Revised:2008-10-26 Online:2009-01-20 Published:2009-01-20
  • Contact: TANG Xiu-fa

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Abstract:

Objective To investigate the expression and clinicopathological significance of transcription factorTwist in human ameloblastoma（AME） and radicular cyst tissues. Methods Immunohistochemistry was used to detect the expression of the Twist in 40 cases of ameloblastoma tissue and 10 cases of radicular cyst tissue. Meanwhile, the Twist protein were detected in 5 cases of ameloblastoma and 1 case of radicular cyst tissue by Western blot. And the expression differences and clinicopathological significances of the Twist were analyzed. Results The positive expression rate of Twist in ameloblastoma tissues was 75.0%, which was significantly higher than that in radicular cyst tissues（20.0%, P<0.05）. Compared with in radicular cyst tissues, the protein expression of Twist were up-regulated in AME. Conclusion Twist has an inappropriate expression in ameloblastoma and it may play an important role in the tumorigenesis and progression of AME.

Key words: ameloblastoma')">ameloblastoma, Twist, epithelial-mesenchymal transition, transcription factor


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[7] . [J]. Foreign Med Sci: Stomatol, 2005, 32(06): 458 -460 .
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