Int J Stomatol

Inter J Stomatol ›› 2018, Vol. 45 ›› Issue (6): 635-639.doi: 10.7518/gjkq.2018.06.003

• RNA Research • Previous Articles     Next Articles

Advances in long non-coding RNA regulation of epithelial-mesenchymal transition in oral squamous cancer

Yiting Wang,Yongwen He()   

  1. Dept. of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital of Kunming Medical University, Kunming 650031, China
  • Received:2017-10-07 Revised:2018-06-11 Online:2018-11-01 Published:2018-11-15
  • Contact: Yongwen He E-mail:heyongwen2@sina.com
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81360401);This study was supported by National Natural Science Foundation of China(81660448)

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Abstract:

Oral cancer is the sixth most common malignancy in the world, and its invasion and metastasis is the leading cause of death. Epithelial-mesenchymal transition (EMT) to epithelial tumour cells play an important role because they can obtain mesenchymal phenotype and enhance the migration and invasion of tumour cells in tumorigenesis, development and metastasis. In recent years, more and more studies have shown that long non-coding RNA (lncRNA) and its associated signalling pathways have become new participants in the induction and regulation of EMT in tumour metastasis. In this paper, the latest research of several lncRNAs involved in EMT regulation of oral cancer is reviewed.

Key words: oral squamous cell carcinoma, long non-coding RNA, epithelial-mesenchymal transition

CLC Number: 

  • R739.8

TrendMD: 
[1] Nieto MA . Epithelial plasticity: a common theme in embryonic and cancer cells[J]. Science, 2013,342(6159):1234850.
doi: 10.1126/science.1234850 pmid: 24202173
[2] Thiery JP, Acloque H, Huang RY , et al. Epithelial-mesenchymal transitions in development and disease[J]. J Oral Maxillofac Pathol, 2014,139(5):871-890.
doi: 10.1016/j.cell.2009.11.007 pmid: 19945376
[3] 平秦榕 . lncRNA调控膀胱癌干细胞上皮-间质转化机制的研究进展[J]. 医学研究生学报, 2017,30(2):220-224.
Ping QR . Research progress on the mechanism of long chain non-coding RNA regulating epithelial-mesenchymal transition of bladder cancer stem cells[J]. J Med Postgraduat, 2017,30(2):220-224.
[4] De Craene B, Berx G . Regulatory networks defining EMT during cancer initiation and progression[J]. Nat Rev Cancer, 2013,13(2):97-110.
doi: 10.1038/nrc3447
[5] Sánchez-Tilló E , Liu YQ, de Barrios O, et al. EMT-activating transcription factors in cancer: beyond EMT and tumor invasiveness[J]. Cell Mol Life Sci, 2012,69(20):3429-3456.
doi: 10.1007/s00018-012-1122-2 pmid: 22945800
[6] Necsulea A, Soumillon M, Warnefors M , et al. The evolution of lncRNA repertoires and expression pat-terns in tetrapods[J]. Nature, 2014,505(7485):635-640.
doi: 10.1038/nature12943 pmid: 24463510
[7] Derrien T, Johnson R, Bussotti G , et al. The GENCODE v7 catalog of human long noncoding RNAs: analysis of their gene structure, evolution, and expression[J]. Genome Res, 2012,22(9):1775-1789.
doi: 10.1101/gr.132159.111 pmid: 22955988
[8] Mani S, Guo WJ, Liao MJ , et al. The epithelial-me-senchymal transition generates cells with properties of stem cells[J]. Cell, 2008,133(4):704-715.
doi: 10.1016/j.cell.2008.03.027 pmid: 18485877
[9] Comings DE . The structure and function of chro-matin[J]. Adv Hum Genet, 1972,3:237-431.
doi: 10.1007/978-1-4757-4429-3_5 pmid: 231929
[10] Meseure D, Drak Alsibai K, Nicolas A , et al. Long noncoding RNAs as new architects in cancer epi-genetics, prognostic biomarkers, and potential the-rapeutic targets[J]. Biomed Res Int, 2015,2015:320214.
[11] Li X, Wu Z, Mei Q , et al. Long non-coding RNA HOTAIR, a driver of malignancy, predicts negative prognosis and exhibits oncogenic activity in oeso-phageal squamous cell carcinoma[J]. Br J Cancer, 2013,109(8):2266-2278.
doi: 10.1038/bjc.2013.548 pmid: 37989551
[12] Gupta RA, Shah N, Wang K , et al. Long non-coding RNA HOTAIR reprograms chromatin state to pro-mote cancer metastasis[J]. Nature, 2010,464(7291):1071-1076.
doi: 10.1038/nature08975 pmid: 20393566
[13] Wu YS, Zhang L, Zhang L , et al. Long non-coding RNA HOTAIR promotes tumor cell invasion and metastasis by recruiting EZH2 and repressing E- cadherin in oral squamous cell carcinoma[J]. Int J Oncol, 2015,46(6):2586-2594.
doi: 10.3892/ijo.2015.2976 pmid: 25901533
[14] Ji P, Diederichs S, Wang WB , et al. MALAT-1, a novel noncoding RNA, and thymosin β4 predict metastasis and survival in early-stage non-small cell lung cancer[J]. Oncogene, 2003,22(39):8031-8041.
doi: 10.1038/sj.onc.1206928
[15] Tang HK, Wu ZY, Zhang JP , et al. Salivary lncRNA as a potential marker for oral squamous cell carcinoma diagnosis[J]. Mol Med Rep, 2013,7(3):761-766.
doi: 10.3892/mmr.2012.1254 pmid: 23292713
[16] Zhou X, Liu S, Cai GS , et al. Long non coding RNA MALAT1 promotes tumor growth and metastasis by inducing epithelial-mesenchymal transition in oral squamous cell carcinoma[J]. Sci Rep, 2015,5:15972.
doi: 10.1038/srep15972 pmid: 4629155
[17] 刘速, 周旋, 王晓非 , 等. 长链非编码RNA MALAT1影响口腔鳞状细胞癌侵袭的实验研究[J]. 中国肿瘤临床, 2015,42(9):460-465.
doi: 10.3969/j.issn.1000-8179.20150313
Liu S, Zhou X, Wang XF , et al. Metastasis-asso-ciated lung adenocarcinoma transcript 1 modulates oral squamous cell carcinoma invasion in vitro and in vivo[J]. Chin J Clin Oncol, 2015,42(9):460-465.
doi: 10.3969/j.issn.1000-8179.20150313
[18] Liang J, Liang LZ, Ouyang KX , et al. MALAT1 induces tongue cancer cells’ EMT and inhibits apop-tosis through Wnt/β-catenin signaling pathway[J]. J Oral Pathol Med, 2017,46(2):98-105.
doi: 10.1111/jop.12466 pmid: 27353727
[19] Li XJ, Ma CH, Zhang L , et al. LncRNAAC132217. 4, a KLF8-regulated long non-coding RNA, facilitates oral squamous cell carcinoma metastasis by upregu-lating IGF2 expression[J]. Cancer Lett, 2017,407:45-56.
doi: 10.1016/j.canlet.2017.08.007 pmid: 28823965
[20] Tan JM, Qiu KF, Li MY , et al. Double-negative feedback loop between long non-coding RNA TUG1 and miR-145 promotes epithelial to mesenchymal transition and radioresistance in human bladder cancer cells[J]. FEBS Lett, 2015,589(20 Pt B):3175-3181.
doi: 10.1016/j.febslet.2015.08.020
[21] Dijkstra JM, Alexander DB . The “NF-κB interac-ting long noncoding RNA” (NKILA) transcript is antisense to cancer-associated gene PMEPA1[J]. F1000Res, 2015,4:96.
doi: 10.12688/f1000research.6400.1 pmid: 260697311
[22] Liu BD, Sun LJ, Liu Q , et al. A cytoplasmic NF-κB interacting long noncoding RNA blocks IκB pho-sphorylation and suppresses breast cancer metastasis[J]. Cancer Cell, 2015,27(3):370-381.
doi: 10.1016/j.ccell.2015.02.004
[23] Huang W, Cui X, Chen JN , et al. Long non-coding RNA NKILA inhibits migration and invasion of ton-gue squamous cell carcinoma cells via suppressing epithelial-mesenchymal transition[J]. Oncotarget, 2016,7(38):62520-62532.
[24] Ling H, Vincent K, Pichler M , et al. Junk DNA and the long non-coding RNA twist in cancer genetics[J]. Oncogene, 2015,34(39):5003-5011.
doi: 10.1038/onc.2014.456 pmid: 25619839
[25] 曲安娜, 何平, 牛慧彦 . 肺癌相关lncRNA调控肿瘤细胞EMT研究进展[J]. 齐鲁医学杂志, 2016,31(5):622-624, 627.
Qu AN, He P, Niu HY . Research progress of lung cancer related lncRNA regulating tumor cell EMT[J]. Med J Qilu, 2016,31(5):622-624, 627.
[26] 曾星, 田允鸿, 张伟军 . 鼻咽癌EMT相关lncRNA的研究进展[J]. 实用医学杂志, 2016,32(15):2568-2570.
doi: 10.3969/j.issn.1006-5725.2016.15.046
Zeng X, Tian YH, Zhang WJ . Research progress of EMT related lncRNA in nasopharyngeal carcinoma[J]. J Pract Med, 2016,32(15):2568-2570.
doi: 10.3969/j.issn.1006-5725.2016.15.046
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