Inter J Stomatol ›› 2018, Vol. 45 ›› Issue (6): 635-639.doi: 10.7518/gjkq.2018.06.003

• RNA Research • Previous Articles     Next Articles

Advances in long non-coding RNA regulation of epithelial-mesenchymal transition in oral squamous cancer

Yiting Wang,Yongwen He()   

  1. Dept. of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital of Kunming Medical University, Kunming 650031, China
  • Received:2017-10-07 Revised:2018-06-11 Online:2018-11-01 Published:2018-11-15
  • Contact: Yongwen He
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81360401);This study was supported by National Natural Science Foundation of China(81660448)


Oral cancer is the sixth most common malignancy in the world, and its invasion and metastasis is the leading cause of death. Epithelial-mesenchymal transition (EMT) to epithelial tumour cells play an important role because they can obtain mesenchymal phenotype and enhance the migration and invasion of tumour cells in tumorigenesis, development and metastasis. In recent years, more and more studies have shown that long non-coding RNA (lncRNA) and its associated signalling pathways have become new participants in the induction and regulation of EMT in tumour metastasis. In this paper, the latest research of several lncRNAs involved in EMT regulation of oral cancer is reviewed.

Key words: oral squamous cell carcinoma, long non-coding RNA, epithelial-mesenchymal transition

CLC Number: 

  • R739.8

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