Int J Stomatol ›› 2020, Vol. 47 ›› Issue (6): 669-676.doi: 10.7518/gjkq.2020088

• Reviews • Previous Articles     Next Articles

Application of photodynamic therapy for oral carcinogenesis prevention

He Yuqing(),Dan Hongxia(),Chen Qianming   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & National Key Laboratory of Oral Mucosal Diseases & Innovation Unit of Oral Mucosal Carcinogenesis and Prevention, Chinese Academy of Medical Sciences & Dept. of Oral Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2019-11-14 Revised:2020-06-02 Online:2020-11-01 Published:2020-11-06
  • Contact: Hongxia Dan;
  • Supported by:
    National Nature Science Foundation of China(81572663)


Oral carcinogenesis starts from the oral mucosa to oral potentially malignant disorder (OPMD) and eventually leads to oral cancer. Substantial effort has been directed to prevent oral carcinogenesis at its early stage; however, success is elusive. Photodynamic therapy is based on photosensitiser-mediated photochemical and photobiological effects leading to cellular damage in lesional tissues. This technique is a new treatment option for OPMD and oral squamous cell carcinoma. This article reviewed the application of photodynamic therapy for oral carcinogenesis prevention.

Key words: photodynamic therapy, oral potentially malignant disorders, oral squamous cell carcinoma, photosensitizer

CLC Number: 

  • R781.5

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