Int J Stomatol

Int J Stomatol ›› 2020, Vol. 47 ›› Issue (6): 669-676.doi: 10.7518/gjkq.2020088

• Reviews • Previous Articles     Next Articles

Application of photodynamic therapy for oral carcinogenesis prevention

He Yuqing(),Dan Hongxia(),Chen Qianming   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & National Key Laboratory of Oral Mucosal Diseases & Innovation Unit of Oral Mucosal Carcinogenesis and Prevention, Chinese Academy of Medical Sciences & Dept. of Oral Medicine, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2019-11-14 Revised:2020-06-02 Online:2020-11-01 Published:2020-11-06
  • Contact: Hongxia Dan E-mail:1193746389@qq.com;hxdan@foxmail.com
  • Supported by:
    National Nature Science Foundation of China(81572663)

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Abstract:

Oral carcinogenesis starts from the oral mucosa to oral potentially malignant disorder (OPMD) and eventually leads to oral cancer. Substantial effort has been directed to prevent oral carcinogenesis at its early stage; however, success is elusive. Photodynamic therapy is based on photosensitiser-mediated photochemical and photobiological effects leading to cellular damage in lesional tissues. This technique is a new treatment option for OPMD and oral squamous cell carcinoma. This article reviewed the application of photodynamic therapy for oral carcinogenesis prevention.

Key words: photodynamic therapy, oral potentially malignant disorders, oral squamous cell carcinoma, photosensitizer

CLC Number: 

  • R781.5

TrendMD: 
[1] Ganesh D, Sreenivasan P, Öhman J, et al. Potentially malignant oral disorders and cancer transformation[J]. Anticancer Res, 2018,38(6):3223-3229.
pmid: 29848669
[2] Mello FW, Miguel AFP, Dutra KL, et al. Prevalence of oral potentially malignant disorders: a systematic review and meta-analysis[J]. J Oral Pathol Med, 2018,47(7):633-640.
doi: 10.1111/jop.12726 pmid: 29738071
[3] Lodi G, Porter S. Management of potentially mali-gnant disorders: evidence and critique[J]. J Oral Pathol Med, 2007,37(2):63-69.
doi: 10.1111/j.1600-0714.2007.00575.x pmid: 18197849
[4] van der Waal I. Oral potentially malignant disorders: is malignant transformation predictable and preventable[J]. Med Oral Patol Oral Cir Bucal, 2014,19(4):e386-e390.
doi: 10.4317/medoral.20205 pmid: 24905952
[5] Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2018,68(6):394-424.
doi: 10.3322/caac.v68.6
[6] Sasahira T, Kirita T. Hallmarks of cancer-related newly prognostic factors of oral squamous cell carcinoma[J]. Int J Mol Sci, 2018,19(8):E2413.
pmid: 30115834
[7] Chi AC, Day TA, Neville BW. Oral cavity and oro-pharyngeal squamous cell carcinoma: an update[J]. CA Cancer J Clin, 2015,65(5):401-421.
pmid: 26215712
[8] Mroueh R, Haapaniemi A, Saarto T, et al. Non-cura-tive treatment of patients with oral tongue squamous-cell carcinoma[J]. Eur Arch Otorhinolaryngol, 2019,276(7):2039-2045.
doi: 10.1007/s00405-019-05456-y pmid: 31069467
[9] Sroussi HY, Epstein JB, Bensadoun RJ, et al. Common oral complications of head and neck cancer radiation therapy: mucositis, infections, saliva change, fibrosis, sensory dysfunctions, dental caries, periodontal disease, and osteoradionecrosis[J]. Cancer Med, 2017,6(12):2918-2931.
doi: 10.1002/cam4.1221 pmid: 29071801
[10] van Straten D, Mashayekhi V, de Bruijn HS, et al. Oncologic photodynamic therapy: basic principles, current clinical status and future directions[J]. Cancers (Basel), 2017,9(2):E19.
[11] Saini R, Lee NV, Liu KY, et al. Prospects in the ap-plication of photodynamic therapy in oral cancer and premalignant lesions[J]. Cancers (Basel), 2016,8(9):E83.
[12] Agostinis P, Berg K, Cengel KA, et al. Photodynamic therapy of cancer: an update[J]. CA Cancer J Clin, 2011,61(4):250-281.
doi: 10.3322/caac.20114 pmid: 21617154
[13] Tan IB, Dolivet G, Ceruse P, et al. Temoporfin-me-diated photodynamic therapy in patients with advanced, incurable head and neck cancer: a multicenter study[J]. Head Neck, 2010,32(12):1597-1604.
pmid: 20848401
[14] Figueira JA, Veltrini VC. Photodynamic therapy in oral potentially malignant disorders—critical litera-ture review of existing protocols[J]. Photodiagnosis Photodyn Ther, 2017,20:125-129.
doi: 10.1016/j.pdpdt.2017.09.007 pmid: 28918177
[15] Rak J, Pouckova P, Benes J, et al. Drug delivery sys-tems for phthalocyanines for photodynamic therapy[J]. Anticancer Res, 2019,39(7):3323-3339.
doi: 10.21873/anticanres.13475 pmid: 31262853
[16] Chen QM, Dan HX, Tang F, et al. Photodynamic the-rapy guidelines for the management of oral leuco-plakia[J]. Int J Oral Sci, 2019,11(2):14.
doi: 10.1038/s41368-019-0047-0 pmid: 30971683
[17] Zhao J, Duan L, Wang AH, et al. Insight into the efficiency of oxygen introduced photodynamic therapy (PDT) and deep PDT against cancers with various assembled nanocarriers[J]. Wiley Interdiscip Rev Nanomed Nanobiotechnol, 2020,12(1):e1583.
doi: 10.1002/wnan.1583 pmid: 31566931
[18] Lin HP, Chen HM, Yu CH, et al. Topical photody-namic therapy is very effective for oral verrucous hyperplasia and oral erythroleukoplakia[J]. J Oral Pathol Med, 2010,39(8):624-630.
pmid: 21054548
[19] Yu CH, Lin HP, Chen HM, et al. Comparison of clinical outcomes of oral erythroleukoplakia treated with photodynamic therapy using either light-emitting diode or laser light[J]. Lasers Surg Med, 2009,41(9):628-633.
doi: 10.1002/lsm.20841 pmid: 19816916
[20] Jin X, Xu H, Deng J, et al. Photodynamic therapy for oral potentially malignant disorders[J]. Photodia-gnosis Photodyn Ther, 2019,28:146-152.
[21] Henderson BW, Busch TM, Snyder JW. Fluence rate as a modulator of PDT mechanisms[J]. Lasers Surg Med, 2006,38(5):489-493.
pmid: 16615136
[22] Chen HM, Yu CH, Tu PC, et al. Successful treatment of oral verrucous hyperplasia and oral leukoplakia with topical 5-aminolevulinic acid-mediated photo-dynamic therapy[J]. Lasers Surg Med, 2005,37(2):114-122.
pmid: 16037967
[23] Warnakulasuriya S, Ariyawardana A. Malignant transformation of oral leukoplakia: a systematic review of observational studies[J]. J Oral Pathol Med, 2016,45(3):155-166.
[24] Lyu MY, Guo YS, Li S, et al. Hospital-based epi-demiological and clinical characterisation of the malignant transformation of oral leukoplakia in a Chinese population[J]. Int Dent J, 2017,67(4):252-259.
pmid: 28276054
[25] Maloth KN, Velpula N, Kodangal S, et al. Photody-namic therapy—a non-invasive treatment modality for precancerous lesions[J]. J Lasers Med Sci, 2016,7(1):30-36.
pmid: 27330695
[26] Han Y, Xu S, Jin JQ, et al. Primary clinical evaluation of photodynamic therapy with oral leukoplakia in Chinese patients[J]. Front Physiol, 2018,9:1911.
pmid: 30723421
[27] Selvam NP, Sadaksharam J, Singaravelu G, et al. Treatment of oral leukoplakia with photodynamic therapy: a pilot study[J]. J Cancer Res Ther, 2015,11(2):464-467.
pmid: 26148619
[28] Shafirstein G, Friedman A, Siegel E, et al. Using 5-aminolevulinic acid and pulsed dye laser for pho-todynamic treatment of oral leukoplakia[J]. Arch Otolaryngol Head Neck Surg, 2011,137(11):1117-1123.
doi: 10.1001/archoto.2011.178 pmid: 22106236
[29] Chen HM, Yu CH, Tsai T, et al. Topical 5-aminolevu-linic acid-mediated photodynamic therapy for oral verrucous hyperplasia, oral leukoplakia and oral erythroleukoplakia[J]. Photodiagnosis Photodyn Ther, 2007,4(1):44-52.
pmid: 25047191
[30] Li YT, Wang BJ, Zheng SW, et al. Photodynamic therapy in the treatment of oral leukoplakia: a syste-matic review[J]. Photodiagnosis Photodyn Ther, 2019,25:17-22.
pmid: 30391342
[31] Pietruska M, Sobaniec S, Bernaczyk P, et al. Clinical evaluation of photodynamic therapy efficacy in the treatment of oral leukoplakia[J]. Photodiagnosis Photodyn Ther, 2014,11(1):34-40.
pmid: 24211597
[32] Chen HM, Cheng SJ, Chiang. Topical photodynamic therapy is the first-line treatment of choice for oral erythroleukoplakia and oral verrucous hyperplasia[J]. J Formos Med Assoc, 2015,114(7):567-568.
pmid: 25937480
[33] Wong SJ, Campbell B, Massey B, et al. A phase Ⅰ trial of aminolevulinic acid-photodynamic therapy for treatment of oral leukoplakia[J]. Oral Oncol, 2013,49(9):970-976.
pmid: 23845699
[34] Prasanna SW, Ingle E, Aruna PR, et al. Photody-namic therapy of oral leukoplakia and oral lichen planus using methylene blue: a pilot study[J]. J Innov Opt Health Sci, 2015,8(1):1540005.
[35] Sulewska M, Duraj E, Sobaniec S, et al. A clinical evaluation of the efficacy of photodynamic therapy in the treatment of erosive oral lichen planus: a case series[J]. Photodiagnosis Photodyn Ther, 2017,18:12-19.
pmid: 28119140
[36] Bakhtiari S, Azari-Marhabi S, Mojahedi SM, et al. Comparing clinical effects of photodynamic therapy as a novel method with topical corticosteroid for treatment of oral lichen planus[J]. Photodiagnosis Photodyn Ther, 2017,20:159-164.
pmid: 28669793
[37] Mostafa D, Moussa E, Alnouaem M. Evaluation of photodynamic therapy in treatment of oral erosive lichen planus in comparison with topically applied corticosteroids[J]. Photodiagnosis Photodyn Ther, 2017,19:56-66.
doi: 10.1016/j.pdpdt.2017.04.014 pmid: 28450262
[38] Sulewska M, Duraj E, Sobaniec S, et al. A clinical evaluation of efficacy of photodynamic therapy in treatment of reticular oral lichen planus: a case series[J]. Photodiagnosis Photodyn Ther, 2019,25:50-57.
doi: 10.1016/j.pdpdt.2018.11.009 pmid: 30447415
[39] Rakesh N, Clint JB, Reddy SS, et al. Clinical eva-luation of photodynamic therapy for the treatment of refractory oral lichen planus—a case series[J]. Photodiagnosis Photodyn Ther, 2018,24:280-285.
doi: 10.1016/j.pdpdt.2018.09.011 pmid: 30261326
[40] Mirza S, Rehman N, Alrahlah A, et al. Efficacy of photodynamic therapy or low level laser therapy against steroid therapy in the treatment of erosive-atrophic oral lichen planus[J]. Photodiagnosis Photo-dyn Ther, 2018,21:404-408.
[41] Sobaniec S, Bernaczyk P, Pietruski J, et al. Clinical assessment of the efficacy of photodynamic therapy in the treatment of oral lichen planus[J]. Lasers Med Sci, 2013,28(1):311-316.
doi: 10.1007/s10103-012-1153-9 pmid: 22814895
[42] Schweitzer VG, Somers ML. PHOTOFRIN-media-ted photodynamic therapy for treatment of early stage (Tis-T2N0M0) SqCCa of oral cavity and oropharynx[J]. Lasers Surg Med, 2010,42(1):1-8.
doi: 10.1002/lsm.20881 pmid: 20077493
[43] Toratani S, Tani R, Kanda, et al. Photodynamic therapy using photofrin and excimer dye laser treatment for superficial oral squamous cell carcinomas with long-term follow up[J]. Photodiagnosis Photodyn Ther, 2016,14:104-110.
pmid: 26747657
[44] Karakullukcu B, van Oudenaarde K, Copper MP, et al. Photodynamic therapy of early stage oral cavity and oropharynx neoplasms: an outcome analysis of 170 patients[J]. Eur Arch Otorhinolaryngol, 2011,268(2):281-288.
doi: 10.1007/s00405-010-1361-5 pmid: 20706842
[45] Jerjes W, Upile T, Hamdoon Z, et al. Photodynamic therapy outcome for T1/T2 N0 oral squamous cell carcinoma[J]. Lasers Surg Med, 2011,43(6):463-469.
doi: 10.1002/lsm.21071 pmid: 21761416
[46] Durbec M, Cosmidis A, Fuchsmann C, et al. Efficacy and safety of photodynamic therapy with temoporfin in curative treatment of recurrent carcinoma of the oral cavity and oropharynx[J]. Eur Arch Otorhino-laryngol, 2013,270(4):1433-1439.
[47] Ikeda H, Tobita T, Ohba S, et al. Treatment outcome of photofrin-based photodynamic therapy for T1 and T2 oral squamous cell carcinoma and dysplasia[J]. Photodiagnosis Photodyn Ther, 2013,10(3):229-235.
pmid: 23993848
[48] Ikeda H, Ohba S, Egashira K, et al. The effect of photodynamic therapy with talaporfin sodium, a second-generation photosensitizer, on oral squamous cell carcinoma: a series of eight cases[J]. Photodia-gnosis Photodyn Ther, 2018,21:176-180.
[49] Yoshida T, Tokashiki R, Ito H, et al. Therapeutic effects of a new photosensitizer for photodynamic therapy of early head and neck cancer in relation to tissue concentration[J]. Auris Nasus Larynx, 2008,35(4):545-551.
pmid: 18242905
[50] Cerrati EW, Nguyen SA, Farrar JD, et al. The ef-ficacy of photodynamic therapy in the treatment of oral squamous cell carcinoma: a meta-analysis[J]. Ear Nose Throat J, 2015,94(2):72-79.
doi: 10.1177/014556131509400208 pmid: 25651350
[51] Elbers JBW, Al-Mamgani A, Paping D, et al. De-finitive (chemo)radiotherapy is a curative alternative for standard of care in advanced stage squamous cell carcinoma of the oral cavity[J]. Oral Oncol, 2017,75:163-168.
pmid: 29224815
[52] Jerjes W, Upile T, Radhi H, et al. Photodynamic therapy and end-stage tongue base cancer: short communication[J]. Head Neck Oncol, 2011,3:49.
pmid: 22152039
[53] Zhang YF, Zhang LL, Yang DG, et al. Treatment of oral refractory large area mucosal leukoplakia with CO2 laser combined with photodynamic therapy: case report[J]. Photodiagnosis Photodyn Ther, 2017,20:193-195.
doi: 10.1016/j.pdpdt.2017.10.006 pmid: 29037909
[54] Wang YY, Yang YD, Yang YC, et al. Surgery com-bined with topical photodynamic therapy for the treatment of squamous cell carcinoma of the lip[J]. Photodiagnosis Photodyn Ther, 2016,14:170-172.
doi: 10.1016/j.pdpdt.2016.04.008 pmid: 27102062
[55] Vander Poorten V, Meulemans J, Nuyts S, et al. Pos-toperative photodynamic therapy as a new adjuvant treatment after robot-assisted salvage surgery of recurrent squamous cell carcinoma of the base of tongue[J]. World J Surg Oncol, 2015,13:214.
doi: 10.1186/s12957-015-0630-6 pmid: 26179387
[56] Shi SR, Zhang LY, Zhu MQ, et al. Reactive oxygen species-responsive nanoparticles based on PEGlated prodrug for targeted treatment of oral tongue squa-mous cell carcinoma by combining photodynamic therapy and chemotherapy[J]. ACS Appl Mater Inter-faces, 2018,10(35):29260-29272.
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[1] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[2] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[3] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[4] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[5] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[6] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[7] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[8] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[9] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[10] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .