Int J Stomatol ›› 2023, Vol. 50 ›› Issue (3): 314-320.doi: 10.7518/gjkq.2023043

• Reviews • Previous Articles     Next Articles

Research progress on mechanism and treatment of sex-determining region Y box 9 in oral squamous cell carcinoma

Sheng Nanning1,2(),Wang Jue1,3(),Nan Xinrong1,4   

  1. 1.School of Stomatology, Shanxi Medical University, Taiyuan 030001, China
    2.Shanxi Province Key Laboratory of Oral Disease Prevention and New Materials, Taiyuan 030001, China
    3.Dept. of Prosthodontics, First Hospital of Shanxi Medical University, Taiyuan 030001, China
    4.Dept. of Oral and Maxillofacial Surgery, First Hospital of Shanxi Medical University, Taiyuan 030001, China
  • Received:2022-09-15 Revised:2023-02-27 Online:2023-05-01 Published:2023-05-16
  • Contact: Jue Wang;
  • Supported by:
    National Natural Science Foundation of China(82003146)


Oral squamous cell carcinoma is the most common malignancy of the head and neck. It has poor prognosis and survival rate that has not improved for many years. Sex-determining region Y box 9 (SOX9) is expressed in malignant tumors of various systems throughout the body. In recent years, SOX9 has become a hotspot in research on tumor surface markers and tumor-targeted therapy. In oral squamous cell carcinoma, SOX9 exhibits complex and diverse effects and may lead to poor prognosis by inducing the development of stem cell features, such as chemotherapy resistance. Understanding the specific role and mechanism of SOX9 in the occurrence, development, and prognosis of OSCC is important to improve the prognosis and survival of oral squamous cell carcinoma. In this paper, the role and mechanism of SOX9 in the early diagnosis, prevention, occurrence, development, and treatment prognosis of oral squamous cell carcinoma are discussed.

Key words: sex-determining region Y box 9, oral squamous cell carcinoma, tumor surface marker

CLC Number: 

  • R 739.8

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