Int J Stomatol

Int J Stomatol ›› 2021, Vol. 48 ›› Issue (2): 205-212.doi: 10.7518/gjkq.2021028

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Research progress on the relationship between circulating tumor cells and oral squamous cell carcinoma

Gan Jianguo1(),Gao Pan2,Wang Xiaoyi1()   

  1. 1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
    2. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of General and Emergency Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2020-06-16 Revised:2020-11-26 Online:2021-03-01 Published:2021-03-17
  • Contact: Xiaoyi Wang E-mail:gandentist@qq.com;wxyz711@163.com
  • Supported by:
    Fund of Basic and Applied Basic Research, West China Hospital of Stomatology, Sichuan University(RD-02-201914)

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Abstract:

Circulating tumour cells (CTCs) are tumour cells that disseminate from primary lesion into the peripheral circulating blood. Studies have linked CTCs to the early diagnosis, therapy, therapeutic evaluation and prognostic assessment of cancers, particularly breast and lung cancers. However, CTCs are seldom used in oral squamous cell carcinoma (OSCC), and their value in OSCC lacks clinical evidences. Current evidence has shown that CTCs are a relatively independent prognostic factor and one of the most important reasons of the recurrence and metastasis of OSCC. This paper reviews the current research status of CTCs in OSCC to further elaborate the mechanism of CTCs formation in OSCC and its detection techniques, explore the clinical importance of the biomarkers of OSCC-related CTCs and understand the progression and prognostic relationship between CTCs and OSCC.

Key words: circulating tumor cells, oral squamous cell carcinoma, prognosis

CLC Number: 

  • R782.2

TrendMD: 

Tab 1

Comparison of commonly used detection methods of CTCs"

方法原理 细胞活力 特异度 敏感度 是否依赖EpCAM
免疫磁珠分离 有 高 低 是
基于细胞大小分离 有 低 低 否
微流体芯片技术 有 高 高 是/否
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