Objective The aim of this systematic review was to analyse the long-term stability of a serious anterior skeletal open-bite malocclusion with orthodontic combined surgical treatments. Methods Data were obtained from SCI, Medline, PubMed, Cochrane Library, EMBASE, Springer, DOI and other foreign databases, such as Chinese Biomedical Literature Database, China National Knowledge Infrastructure database, VIP database for Chinese technical periodicals, the digital journal of Wan Fang Data and other Chinese databases. The literatures, which consisted of randomised controlled trials, quasi-randomised controlled trials and clinical case-control trials, were selected and evaluated independently by two investigators in accordance with the inclusion and exclusion criteria. Then, Meta-analysis was performed on the literatures that met the inclusion criteria. Results The six references (five foreign articles and one Chinese article) that met the requirements were pre-post case-control studies with a total of 220 patients. Meta-analysis showed that SNA, SNB, ANB, MP-PP, SN-PP, N-Me, ANS-Me, S-G0, OB, OJ, L1-MP/(°), L1-MP/mm, U1-PP/(°) and U1-PP/mm before operation and at least 1 year after operation had no statistical difference, whereas MP-SN had statistical difference.Conclusion Orthodontic and surgical treatment for serious anterior skeletal open-bite malocclusion could keep relative stability, except a little replace of the mandibular.
