Int J Stomatol ›› 2021, Vol. 48 ›› Issue (2): 141-146.doi: 10.7518/gjkq.2021045

• Oral Medicine • Previous Articles     Next Articles

Research advances in the relationship between oral lichen planus and cardiovascular diseases

Liu Siyu1,2(),Li Xin3,Xu Xiaoyu1,Sun Yinyin1,Pan Yingxiao4,Wang Sainan5,Lu Shulai2()   

  1. 1. Graduate School of Dalian Medical University, Dalian 116044, China
    2. Stomatology Center of Qingdao Municipal Hospital, Qingdao 266011, China
    3. Dept. of Stomatology, Shandong Provincial Hospital, Jinan 250021, China
    4. School of Stomatology, Qingdao University, Qingdao 266011, China
    5. Dept. of Stomatology, Binzhou People,s Hospital, Binzhou 256600, China
  • Received:2020-08-05 Revised:2020-12-02 Online:2021-03-01 Published:2021-03-17
  • Contact: Shulai Lu E-mail:siyuliu456@163.com;lshl97@163.com
  • Supported by:
    Qingdao Science and Technology Plan Project(17-3-3-39-nsh);Leadership Project of Qingdao Medical and Health Excellent Subjects (2020)

Abstract:

Oral lichen planus is a common oral mucosal disease. Cardiovascular diseases are a series of diseases affecting the circulatory system and the world,s leading causes of death. The relationship between cardiovascular diseases and lichen planus has been investigated, and a certain correlation between them has been found. This article reviews the relevance of oral lichen planus and cardiovascular diseases in epidemiology, risk factors, inflammatory mediators, and clinical treatment.

Key words: oral lichen planus, cardiovascular diseases, correlation, inflammatory mediator

CLC Number: 

  • R781.5

TrendMD: 
[1] 陈谦明. 口腔黏膜病学[M]. 4版. 北京: 人民卫生出版社, 2013: 103-110.
Chen QM. Oral mucosal diseases[M]. 4th ed. Beijing: People,s Medical Publishing House, 2013: 103-110.
[2] Ofori-Asenso R, Garcia D. Cardiovascular diseases in Ghana within the context of globalization[J]. Cardiovasc Diagn Ther, 2016,6(1):67-77.
doi: 10.3978/j.issn.2223-3652.2015.09.02 pmid: 26885494
[3] Dreiher J, Shapiro J, Cohen AD. Lichen planus and dyslipidaemia: a case-control study[J]. Br J Dermatol, 2009,161(3):626-629.
pmid: 19438850
[4] Arias-Santiago S, Buendía-Eisman A, Aneiros-Fer-nández J, et al. Lipid levels in patients with lichen planus: a case-control study[J]. J Eur Acad Dermatol Venereol, 2011,25(12):1398-1401.
doi: 10.1111/j.1468-3083.2011.03983.x pmid: 21348899
[5] Aniyan KY, Guledgud MV, Patil K. Alterations of serum lipid profile patterns in oral lichen planus patients: a case-control study[J]. Contemp Clin Dent, 2018,9(Suppl 1):S112-S121.
doi: 10.4103/ccd.ccd_111_18 pmid: 29962775
[6] López-Jornet P, Camacho-Alonso F, Rodríguez-Mar-tínes MA. Alterations in serum lipid profile patterns in oral lichen planus: a cross-sectional study[J]. Am J Clin Dermatol, 2012,13(6):399-404.
[7] Ozbagcivan O, Akarsu S, Semiz F, et al. Comparison of serum lipid parameters between patients with classic cutaneous lichen planus and oral lichen planus[J]. Clin Oral Investig, 2020,24(2):719-725.
doi: 10.1007/s00784-019-02961-6 pmid: 31129877
[8] Sahin M, Bilgili SG, Simsek H, et al. Increased P-wave dispersion in patients with newly diagnosed lichen planus[J]. Clinics (Sao Paulo), 2013,68(6):846-850.
doi: 10.6061/clinics
[9] Aditi R, Sathasivasubramanian S, Bhaskar ME. Association of oral lichen planus and electrocardiographic P-wave dispersion-an original research[J]. Braz Dent J, 2017,28(6):699-703.
pmid: 29211124
[10] Rashed L, Abdel Hay R, AlKaffas MM, et al. Studying the association between methylenetetrahydrofolate reductase (MTHFR) 677 gene polymorphism, cardiovascular risk and lichen planus[J]. J Oral Pathol Med, 2017,46(10):1023-1029.
doi: 10.1111/jop.12588 pmid: 28463405
[11] Aksu F, Karadag AS, Caliskan M, et al. Does lichen planus cause increased carotid intima-media thickness and impaired endothelial function[J]. Can J Cardiol, 2016, 32(10): 1246.e1-1246.e6.
doi: 10.1016/j.cjca.2015.11.016
[12] 潘蕾. 口腔扁平苔藓患者心血管疾病风险研究[D]. 上海: 上海交通大学, 2016.
Pan L. A research about risk of cardiovascular disea-ses of patients with oral lichen planus[D]. Shanghai: Shanghai Jiao Tong University, 2016.
[13] Grinspan D, Diaz J, Villapol Lo, et al. Lichen ruber planus of the buccal mucosa. Its association with diabetes[J]. Bull Soc Fr Dermatol Syphiligr, 1966,73(6):898-899.
pmid: 5987868
[14] Sallay K, Kövesi G, Döri F. Circulating immune complex studies on patients with oral lichen planus[J]. Oral Surg Oral Med Oral Pathol, 1989,68(5):567-570.
doi: 10.1016/0030-4220(89)90241-7 pmid: 2812711
[15] Kumar P, Mastan K, Chowdhary R, et al. Oral manifestations in hypertensive patients: a clinical study[J]. J Oral Maxillofac Pathol, 2012,16(2):215-221.
doi: 10.4103/0973-029X.99069 pmid: 22923893
[16] Mozaffari HR, Sharifi R, Sadeghi M. Prevalence of oral lichen planus in diabetes mellitus: a meta-analysis study[J]. Acta Inform Med, 2016,24(6):390-393.
doi: 10.5455/aim.2016.24.390-393 pmid: 28077900
[17] Ahmed I, Nasreen S, Jehangir U, et al. Frequency of oral lichen planus in patients with noninsulin dependent diabetes mellitus[J]. J Pak Assoc Derm, 2017,22(1):30-34.
[18] Nazir MA, AlGhamdi L, AlKadi M, et al. The burden of diabetes, its oral complications and their prevention and management[J]. Open Access Maced J Med Sci, 2018,6(8):1545-1553.
doi: 10.3889/oamjms.2018.294 pmid: 30159091
[19] Kalkur C, Sattur AP, Guttal KS. Role of depression, anxiety and stress in patients with oral lichen planus: a pilot study[J]. Indian J Dermatol, 2015,60(5):445-449.
doi: 10.4103/0019-5154.159625 pmid: 26538689
[20] Pippi R, Romeo U, Santoro M, et al. Psychological disorders and oral lichen planus: matched case-control study and literature review[J]. Oral Dis, 2016,22(3):226-234.
doi: 10.1111/odi.12423 pmid: 26680999
[21] Vilar-Villanueva M, Gándara-Vila P, Blanco-Aguilera E, et al. Psychological disorders and quality of life in oral lichen planus patients and a control group[J]. Oral Dis, 2019,25(6):1645-1651.
doi: 10.1111/odi.13106 pmid: 30993798
[22] Gupta S, Jawanda MK. Oral lichen planus: an update on etiology, pathogenesis, clinical presentation, diagnosis and management[J]. Indian J Dermatol, 2015,60(3):222-229.
doi: 10.4103/0019-5154.156315 pmid: 26120146
[23] Joseph P, Leong D, McKee M, et al. Reducing the global burden of cardiovascular disease, part 1: the epidemiology and risk factors[J]. Circ Res, 2017,121(6):677-694.
doi: 10.1161/CIRCRESAHA.117.308903 pmid: 28860318
[24] Kurago ZB. Etiology and pathogenesis of oral lichen planus: an overview[J]. Oral Surg Oral Med Oral Pathol Oral Radiol, 2016,122(1):72-80.
doi: 10.1016/j.oooo.2016.03.011 pmid: 27260276
[25] Karatsaidis A, Hayashi K, Schreurs O, et al. Survival signalling in keratinocytes of erythematous oral lichen planus[J]. J Oral Pathol Med, 2007,36(4):215-222.
doi: 10.1111/j.1600-0714.2007.00519.x pmid: 17391299
[26] Kaur J, Jacobs R. Proinflammatory cytokine levels in oral lichen planus, oral leukoplakia, and oral submucous fibrosis[J]. J Korean Assoc Oral Maxillofac Surg, 2015,41(4):171-175.
doi: 10.5125/jkaoms.2015.41.4.171 pmid: 26339574
[27] 肖述铜, 徐凡, 黄卫东. 心血管疾病与牙周炎关系的研究进展[J]. 临床口腔医学杂志, 2018,34(2):120-122.
Xiao ST, Xu F, Huang WD. Research progress on the relationship between cardiovascular disease and periodontitis[J]. J Clin Stomatol, 2018,34(2):120-122.
[28] Gu GM, Martin MD, Darveau RP, et al. Oral and serum IL-6 levels in oral lichen planus patients[J]. Oral Surg Oral Med Oral Pathol Oral Radiol Endod, 2004,98(6):673-678.
doi: 10.1016/j.tripleo.2004.05.006 pmid: 15583539
[29] Mozaffari HR, Sharifi R, Sadeghi M. Interleukin-6 levels in the serum and saliva of patients with oral lichen planus compared with healthy controls: a meta-analysis study[J]. Cent Eur J Immunol, 2018,43(1):103-108.
doi: 10.5114/ceji.2018.74880 pmid: 29731693
[30] Saleh N, Samir N, Megahed H, et al. Homocysteine and other cardiovascular risk factors in patients with lichen planus[J]. J Eur Acad Dermatol Venereol, 2014,28(11):1507-1513.
doi: 10.1111/jdv.12329 pmid: 24330130
[31] Chen HM, Wang YP, Chang JY, et al. Significant association of deficiencies of hemoglobin, iron, folic acid, and vitamin B12 and high homocysteine level with oral lichen planus[J]. J Formos Med Assoc, 2015,114(2):124-129.
doi: 10.1016/j.jfma.2014.10.004 pmid: 25557154
[32] Ganguly P, Alam SF. Role of homocysteine in the development of cardiovascular disease[J]. Nutr J, 2015,14:6.
doi: 10.1186/1475-2891-14-6 pmid: 25577237
[33] Lominadze D, Dean WL, Tyagi SC, et al. Mechanisms of fibrinogen-induced microvascular dysfunction during cardiovascular disease[J]. Acta Physiol (Oxf), 2010,198(1):1-13.
[34] Kamath DY, Xavier D, Sigamani A, et al. High sensitivity C-reactive protein (hsCRP) & cardiovascular disease: an Indian perspective[J]. Indian J Med Res, 2015,142(3):261-268.
doi: 10.4103/0971-5916.166582 pmid: 26458341
[35] Santoro A, Majorana A, Bardellini E, et al. NF‐kappa B expression in oral and cutaneous lichen planus[J]. J Pathol, 2003,201(3):466-472.
doi: 10.1002/path.1423 pmid: 14595759
[36] Yu XH, Zheng XL, Tang CK. Nuclear factor-κB activation as a pathological mechanism of lipid metabolism and atherosclerosis[J]. Adv Clin Chem, 2015,70:1-30.
doi: 10.1016/bs.acc.2015.03.004 pmid: 26231484
[37] Gupta S, Ghosh S, Gupta S. Interventions for the management of oral lichen planus: a review of the conventional and novel therapies[J]. Oral Dis, 2017,23(8):1029-1042.
doi: 10.1111/odi.12634 pmid: 28055124
[38] Habbab KM, Moles DR, Porter SR. Potential oral manifestations of cardiovascular drugs[J]. Oral Dis, 2010,16(8):769-773.
doi: 10.1111/j.1601-0825.2010.01686.x pmid: 20604876
[39] Balakumar P, Kavitha M, Nanditha S. Cardiovascular drugs-induced oral toxicities: a murky area to be revisited and illuminated[J]. Pharmacol Res, 2015,102:81-89.
doi: 10.1016/j.phrs.2015.09.007 pmid: 26409645
[1] Li Ran,Hu Yue,Zhang Ning,Gao Ruifang,Wang Xiangyu,Ge Xuejun. The correlation study between single nucleotide polymorphisms of Toll-like receptor and interleukin-17 and oral lichen planus [J]. Int J Stomatol, 2024, 51(1): 45-51.
[2] Wang Sujie,Tan Qin,Wei Yuan,Wang Jie,Fan Jie,Yue Erli.. Correlation analysis of serum angiopoietin-2 level with forkhead/winged helix transcription factor p3 regulatory T cells and disease activity in patients with oral lichen planus [J]. Int J Stomatol, 2023, 50(6): 674-678.
[3] He Jing,Hu Mingjia,Xiao Ning,Li Jia,Sun Wanxin,Ling Lü,Liu Fan. Investigation on the degree of psychological distress and its influencing factors in patients with oral lichen planus [J]. Int J Stomatol, 2023, 50(3): 308-313.
[4] Zhang Shenyi,Wang Xiangjian,Shi Liran,Shi Jiahong,Wang Yuhong,Zhou Hongmei. Oral beta-carotene in the treatment of non-erosive oral lichen planus: a randomized controlled trial [J]. Int J Stomatol, 2022, 49(6): 633-640.
[5] Chen Siting,Zhong Xiong,Meng Wenxia.. Research progress on Nod-like receptor protein 3 inflammasome in oral mucosal diseases [J]. Int J Stomatol, 2022, 49(4): 471-475.
[6] Feng Lu,Meng Wenxia. Research progress on the problems of dental implant treatment in patients with common oral mucosal disease [J]. Int J Stomatol, 2021, 48(2): 147-155.
[7] Li Yeping,Zheng Qian,Yin Heng,Guo Chunli,Shi Bing,Li Chenghao. Exploration on nasal objective measurements affecting subjective evaluation of the secondary reconstruction of unilateral cleft lip nasal deformity [J]. Int J Stomatol, 2019, 46(4): 407-412.
[8] Yuan Zhenying,Guan Cuiqiang,Nan Xinrong. Research progress on DNA methylation and oral disease [J]. Int J Stomatol, 2019, 46(4): 437-441.
[9] Shuaihua Qin,Xinming Li,Wenlu Li. Evaluation and correlation analysis of quality of life and coping strategies in patients with symptomatic oral lichen planus [J]. Int J Stomatol, 2019, 46(3): 282-286.
[10] Guo Chunli, Yin Heng, Li Chenghao, Shi Bing, Zheng Qian. Investigation of the factors about re-examination rate of the patients with cleft palate [J]. Inter J Stomatol, 2016, 43(4): 380-382.
[11] Zhou Yi, Sun Xiurong, Liu Xueli, Yan Shixia. Effect of psychological intervention on the treatment of oral lichen planus [J]. Inter J Stomatol, 2016, 43(1): 22-.
[12] Wang Yuhong, Wu Zhongting, Zhou Hongmei.. Different response to treatment in the different sites of oral lichen planus: a case report [J]. Inter J Stomatol, 2015, 42(4): 430-431.
[13] Wang Xiaxia, Sun Hongying. Hypoxia-inducible factor-1α and oral lichen planus [J]. Inter J Stomatol, 2015, 42(3): 318-322.
[14] Tang Jinju, Yang Yongjin. Relationship between Helicobacter pylori and recurrent aphthous ulcer [J]. Inter J Stomatol, 2015, 42(1): 89-92.
[15] Liu Jiajia, Wu Yuanqin, Zeng Xin, Zhou Yu.. Function of microRNAs in oral lichen planus [J]. Inter J Stomatol, 2015, 42(1): 48-53.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[2] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[3] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[4] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[5] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[6] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[7] . [J]. Foreign Med Sci: Stomatol, 2005, 32(06): 458 -460 .
[8] . [J]. Foreign Med Sci: Stomatol, 2005, 32(06): 452 -454 .
[9] . [J]. Inter J Stomatol, 2008, 35(S1): .
[10] . [J]. Inter J Stomatol, 2008, 35(S1): .