口腔扁平苔藓患者血清血管生成素-2水平与叉头翼状螺旋转录因子阳性调节性T细胞及疾病活动度的相关性分析

doi:10.7518/gjkq.2023096

Abstract

Abstract:

Objective This study aims to explore the relationship between serum angiopoietin-2 (Ang-2) levels and forkhead/winged helix transcription factor p3 (Foxp3)-positive regulatory T cells (Treg) and disease activity in patients with oral lichen planus (OLP). Methods A total of 113 patients with different types of OLP were selected (observation group), including 45 cases of reticular type, 36 cases of hyperemia type, and 32 cases of erosion type. Another 76 healthy volunteers (control group) were included. Serum Ang-2 and Foxp3⁺ Treg levels were detected by enzyme-linked immunosorbent assay and flow cytometry, respectively. Clinical sign scores, reticular-atrophic-erosive (RAE) lesion scores and disease activity scores of patients with OLP were analyzed. Pearson correlation analysis was used to clarify the correlation between each score and levels of Ang-2 and Foxp3⁺Treg. Results The levels of Ang-2 and Foxp3⁺Treg in the serum of patients with OLP of different types were higher than those in the control group (P<0.05). The serum levels of Ang-2 and Foxp3⁺Treg were higher in patients with erosive and hyperemia types than in patients with the reticuloid type (P<0.05). Compared with the hyperemia type, the serum le-vels of Ang-2 and Foxp3⁺ Treg in patients with erosive type were higher (P<0.05). The clinical sign scores, RAE lesion scores, and disease activity scores of erosive and hyperemic patients were higher than those of patients with the reticulated type (P<0.05). Patients with erosion type had higher levels of the above indices than patients with the hyperemia type (P<0.05). The serum levels of Ang-2 in patients with OLP was positively correlated with Foxp3⁺ Treg, clinical sign scores, RAE lesion scores, and disease activity scores (r=0.531, 0.548, 0.554, 0.528, P<0.001). Conclusion Serum Ang-2 levels were abnormally elevated in patients with OLP, and the level of elevation was positively correlated with Foxp3⁺Treg levels, clinical signs, lesions, and disease activity.

Key words: angiopoietin-2, oral lichen planus, forkhead/winged helix transcription factor p3, regulatory T cell, disease activity

CLC Number:

R 781.5

TrendMD:

Wang Sujie,Tan Qin,Wei Yuan,Wang Jie,Fan Jie,Yue Erli.. Correlation analysis of serum angiopoietin-2 level with forkhead/winged helix transcription factor p3 regulatory T cells and disease activity in patients with oral lichen planus[J].Int J Stomatol, 2023, 50(6): 674-678.

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组别	例数	Ang-2/ng·mL^-1	Foxp3⁺Treg细胞数
对照	76	0.32±0.12	2.64±0.58
网纹型	45	0.76±0.13^a	23.46±4.32^a
充血型	36	2.42±0.46^ab	31.28±5.02^ab
糜烂型	32	3.89±0.78^abc	39.46±5.48^abc
F值		752.502	928.602
P值		<0.001	<0.001

组别	例数	临床体征评分	RAE病损评分	疾病活动评分
网纹型	45	1.13±0.26	11.18±1.34	10.24±1.42
充血型	36	2.48±0.35^b	12.76±0.76^b	18.83±1.78^b
糜烂型	32	4.26±0.38^bc	14.61±0.71^bc	26.85±2.14^bc
F值		858.734	105.645	842.006
P值		<0.001	<0.001	<0.001

Correlation analysis of serum angiopoietin-2 level with forkhead/winged helix transcription factor p3 regulatory T cells and disease activity in patients with oral lichen planus

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