Int J Stomatol

Int J Stomatol ›› 2020, Vol. 47 ›› Issue (2): 166-174.doi: 10.7518/gjkq.2020051

• Original Articles • Previous Articles     Next Articles

Survival analysis of patients with oral squamous cell carcinoma treated by radical surgery for the first time

Xue Lingli,Li Yadong()   

  1. Dept. of Oral and Maxillofacial Surgery, The First Affiliated Hospital of Chongqing Medical University, Chongqing 400010, China
  • Received:2019-06-25 Revised:2019-09-30 Online:2020-03-01 Published:2020-03-12
  • Contact: Yadong Li E-mail:llxxyydd2006@sina.com
  • Supported by:
    This study was supported by Natural Science Foundation Project of Chongqing Science and Technology Committee(cstc2018jcyjAX07-63);Medical High-end Reserve Talent Training Program of Chongqing Health and Family Planning Committee(2017HBRC004);Project of Chongqing Education Commission(15SKG032)

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Abstract:

Objective To analyze the overall survival (OS) and relevant risk factors for oral squamous cell carcinoma (OSCC) patients. Methods To retrospectively review the clinical, pathological, and follow-up records of 78 patients after primary radical tumor resection. Descriptive statistics were calculated for each variable, survival was calculated using the Kaplan-Meier method, differences in OS rate were analyzed via a log-rank test, and univariate and multivariate Cox proportional hazard models were performed to analyze the factors associated with overall survival and prognosis. Results A total of 68 patients were included in the final study. The five-year OS rate was 55.9%. The median survival time of the patients who died of this disease within five years was 20.5 (6-52) months. The univariate analysis showed that clinical stage, tumor size, lymph node metastasis, pathological differentiation, recurrence, and metastasis were the exposure factors affecting survival time (P<0.05). Multivariate analysis showed that pathological differentiation, recurrence, and metastasis were in-dependent factors affecting survival time (P<0.05). The patients with esophageal squamous cell carcinoma accounted for 5.1% (4/78) in total 78 OSCC. Conclusion The survival prognosis of patients with oral squamous cell carcinoma is correlated with clinical stage (TNM stage), tumor size, lymph node metastasis, pathological differentiation, recurrence, and metastasis. In this study, pathological differentiation, recurrence, and metastasis were independent factors affecting survival time. Some OSCC patients may be screened for esophageal squamous cell carcinoma.

Key words: oral squamous cell carcinoma, survival rate, prognosis, influence factors, esophageal squamous cell carcinoma

CLC Number: 

  • R730.7

TrendMD: 

Tab 1

Basic demographic data and univariate analysis results associated with survival"

变量 例数及百分比1) 5年生存情况 COX生存时间单因素分析
生存组（n=38）2) 死亡组（n=30）3) T/χ²检验P值
n % B P值 HR（95%CI）
n % n %
性别 男 45 66.2 25 65.8 20 66.7 0.939 0.029 0.940 1.029（0.484~2.188）
女 23 33.8 13 34.2 10 33.3
年龄/岁 60.9±10.64) 58.9±11.15) 63.5±9.66)
≤60 35 51.5 23 60.5 12 40.0 0.093 0.627 0.090 1.872（0.906~3.864）
>60 33 48.5 15 39.5 18 60.0
病程/月 5（3~12）7) 5.5（3~12）8) 4（2~7.5）9) 0.098 -0.068 0.088 0.934（0.864~1.010）
高血压 有 14 20.6 6 15.8 8 26.7 0.271 0.461 0.262 1.586（0.708~3.553）
无 54 79.4 32 84.2 22 73.3
糖尿病 有 9 13.2 7 18.4 2 6.7 0.156 -0.895 0.221 0.409（0.097~1.715）
无 59 86.8 31 81.6 28 93.3
吸烟 有 36 52.9 18 47.3 18 60.0 0.300 0.403 0.275 1.496（0.726~3.085）
无 32 47.1 20 52.6 12 40.0
饮酒 有 27 39.7 12 31.6 15 50.0 0.123 0.581 0.108 1.788（0.880~3.632）
无 41 60.3 26 68.4 15 50.0
部位 舌 24 35.3 14 36.8 10 33.3 0.642 0.105 0.406 1.111（0.867~1.423）
颊 21 30.9 14 36.8 7 23.3
牙龈 9 13.2 4 10.5 5 16.7
腭 5 7.4 2 5.3 3 10.0
口底 9 13.2 4 10.5 5 16.7
临床分期 早（Ⅰ、Ⅱ） 33 48.5 23 60.5 10 33.3 0.026 0.858 0.023 2.358（1.126~4.939）
中、晚（Ⅲ、Ⅳ） 35 51.5 15 39.5 20 66.7
T分期 T1 8 11.8 6 15.8 2 6.7 0.141 0.599 0.022 1.820（1.090~3.040）
T2 37 54.4 22 57.9 15 50.0
T3 20 29.4 10 26.3 10 33.3
T4 3 4.4 0 0 3 10.0
淋巴结转移 有 24 35.3 8 21.1 16 53.3 0.006 1.163 0.001 3.200（1.569~6.524）
无 44 64.7 30 78.9 14 46.7
病理分化 高 48 70.6 33 86.8 15 50.0 0.001 1.232 0.001 3.429（1.662~7.077）
中、低 20 29.4 5 13.2 15 50.0
复发转移 无 32 47.1 29 76.3 3 10.0 <0.001 1.175 <0.001 3.238（2.187~4.796）
原位 14 20.6 7 18.4 7 23.3
颈部 17 25.0 2 5.3 15 50.0
远处 5 7.3 0 0 5 16.7

Fig 1

The survival curve of 68 patients with OSCC"

Fig 2

The survival curves for TNM stage"

Fig 3

The survival curves for tumor size"

Fig 4

The survival curves for lymphatic metastasis"

Fig 5

The survival curves for pathological differentiation"

Fig 6

The survival curves for recurrence and metastasis"

Tab 2

Multivariate analysis results associated with sur-vival"

变量 B P值 HR（95%CI）
临床分期 -0.434 0.442 0.648（0.214~1.959）
T分期 0.205 0.527 1.227（0.650~2.315）
淋巴结转移 0.760 0.098 2.139（0.869~5.269）
病理分化 0.958 0.015 2.607（1.205~5.638）
复发转移 1.041 <0.001 2.832（1.851~4.333）
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