Int J Stomatol

Int J Stomatol ›› 2021, Vol. 48 ›› Issue (6): 711-717.doi: 10.7518/gjkq.2021109

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Exosomes mediate the malignant progression of oral squamous cell carcinoma and its application in diagnosis and treatment

Jiang Yulei(),Xia Bin,Rao Nanquan,Yang Hefeng,Xu Biao()   

  1. Dept. of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital of Kunming Medical University, Kunming 650500, China
  • Received:2021-03-28 Revised:2021-07-10 Online:2021-11-01 Published:2021-10-28
  • Contact: Biao Xu E-mail:2523759018@qq.com;xubiao1962@yahoo.com.cn
  • Supported by:
    Natural Science Foundation of Yunnan Province(2018rs0210)

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Abstract:

Exosomes are extracellular vesicles that play an important role in intercellular communication and are widely present in human body fluids. Exosomes exert biological effects by carrying various active substances, such as proteins, mRNA, microRNA, and DNA. For example, those secreted by oral squamous cell carcinoma (OSCC) can affect the tumor microenvironment and promote the development of tumors by activating various signal pathways. Therefore, these vesicles provide a new treatment strategy for assisting the early diagnosis and prognosis of OSCC. Owing to their unique interaction in the tumor microenvironment, exosomes and their modified products can be used as effective carriers of genes and drugs for targeted OSCC therapy. This article reviews the production of exosomes, their role in OSCC, and the clinical diagnosis and treatment of exosomes in OSCC.

Key words: exosome, oral squamous cell carcinoma, targeted therapy

CLC Number: 

  • R739.8

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