Int J Stomatol ›› 2022, Vol. 49 ›› Issue (4): 462-470.doi: 10.7518/gjkq.2022044

• Reviews • Previous Articles     Next Articles

Research progress on the use of photothermal therapy to treat oral squamous cell carcinoma

Zhao Zhuoping1(),Xin Pengfei2,3,Gao Yang2,3,Zhang Caifeng4,Zhang Kuanshou5,Liu Qingmei1,2,3()   

  1. 1.Shanxi Medical University, School and Hospital of Stomatology, Taiyuan 030001, China
    2.Dept of Stomatology, Third Hospital of Shanxi Medical University, Shanxi Bethune Hospital, Shanxi Academy of Medical Sciences, Tongji Shanxi Hospital, Taiyuan 030032, China
    3.Tongji Hosptial, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
    4.Dept. of Chemistry, Taiyuan Normal University, Shanxi Humic Acid Engineering Technology Research Center, Jinzhong 030619, China
    5.State Key Laboratory of Quantum Optics and Quantum Optics Devices, Institute of Opto-Electronics, Shanxi University, Collaborative Innovation Center of Extreme Optics, Shanxi University, Taiyuan 030006, China
  • Received:2021-11-01 Revised:2022-03-12 Online:2022-07-01 Published:2022-06-28
  • Contact: Qingmei Liu;
  • Supported by:
    Scientific Research Project of Health Commission of Shanxi Province(2018017);Fund for Shanxi “1331 Project” Collaborative Innovation Center, and Program of State Key Laboratory of Quantum Optics and Quantum Optics Devices (Shanxi University)(KF202105)


At present, the most clinically applied and researched treatments for oral squamous cell carcinoma (OSCC) mainly include surgery, radiotherapy, chemotherapy, traditional hyperthermia, gene therapy, immunotherapy, and photodynamic therapy. However, the therapeutic effect of these treatments is limited and often accompanied by varying degrees of side effects. Photothermal therapy (PTT) is a novel type of treatment method that can selectively kill cancer cells through photothermal effect with high safety. The two elements of PTT are near infrared with good tissue penetration and photothermal conversion agents with modifiability and selectivity. By building nanocar-rier platforms, PTT can synergistically enhance the efficacy of other therapies and reduce their side effects. In this paper, the current treatment status of OSCC, the photothermal conversion principle of PTT, and its application in the treatment of OSCC were reviewed to provide a theoretical basis for the treatment of OSCC using PTT.

Key words: oral squamous cell carcinoma, photothermal therapy, photothermal effect, near infrared, photothermal conversion agent

CLC Number: 

  • R 739.81

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