Int J Stomatol

Int J Stomatol ›› 2023, Vol. 50 ›› Issue (6): 711-717.doi: 10.7518/gjkq.2023110

• Reviews • Previous Articles     Next Articles

Research progress on cancer-associated fibroblasts in the tumor microenvironment of oral squamous cell carcinoma

Wu Jiamin(),Xia Bin,Yang Hefeng,Xu Biao.()   

  1. Dept. of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital of Kunming Medical University, Kunming 650500, China
  • Received:2023-03-25 Revised:2023-07-26 Online:2023-11-01 Published:2023-10-24
  • Contact: Biao. Xu E-mail:694467788@qq.com;xubiao1962@yahoo.com.cn
  • Supported by:
    Yunnan Provincial Key Laboratory of Stomatology(202005AG070041);Yunnan Provincial Health Commission Internal Institutions Project(2018NS0210)

RichHTML

15

PDF (PC)

645

Abstract:

Cancer-associated fibroblasts are the most abundant stromal cells in the tumor microenvironment. An increasing number of studies have found that cancer-associated fibroblasts play a remarkable role in the development of tumors. Cancer-associated fibroblasts remodel the extracellular matrix, regulate tumor metabolism, and participate in immune regulation, and promote tumor growth, angiogenesis, migration, and invasion. Therefore, disrupting the interaction between cancer-associated fibroblasts and the surrounding environment may provide us with new therapeutic ideas. In this paper, we will review the research progress on cancer-associated fibroblasts in oral squamous carcinoma.

Key words: cancer-associated fibroblast, oral squamous cell carcinoma, tumor microenvironment

CLC Number: 

  • R 739.81

TrendMD: 
1 Chi AC, Day TA, Neville BW. Oral cavity and oropharyngeal squamous cell carcinoma: an update[J]. CA Cancer J Clin, 2015, 65(5): 401-421.
2 Santos Peixoto T, Gomes MC, de Castro Gomes DQ, et al. Analysis of survival rates and prognostic factors among patients with oral squamous cell carcinoma[J]. J Public Heath, 2017, 25(4): 433-441.
3 Hui LL, Chen Y. Tumor microenvironment: sanc-tuary of the devil[J]. Cancer Lett, 2015, 368(1): 7-13.
4 Denton AE, Roberts EW, Fearon DT. Stromal cells in the tumor microenvironment[J]. Adv Exp Med Biol, 2018, 1060: 99-114.
5 Kalluri R. The biology and function of fibroblasts in cancer[J]. Nat Rev Cancer, 2016, 16(9): 582-598.
6 Chen XM, Song EW. Turning foes to friends: targe-ting cancer-associated fibroblasts[J]. Nat Rev Drug Discov, 2019, 18(2): 99-115.
7 Xiao Y, Yu DH. Tumor microenvironment as a therapeutic target in cancer[J]. Pharmacol Ther, 2021, 221: 107753.
8 Sahai E, Astsaturov I, Cukierman E, et al. A framework for advancing our understanding of cancer-associated fibroblasts[J]. Nat Rev Cancer, 2020, 20(3): 174-186.
9 Desbois M, Wang YL. Cancer-associated fibroblasts: key players in shaping the tumor immune microenvironment[J]. Immunol Rev, 2021, 302(1): 241-258.
10 Li C, Teixeira AF, Zhu HJ, et al. Cancer associated-fibroblast-derived exosomes in cancer progression[J]. Mol Cancer, 2021, 20(1): 154.
11 Joshi RS, Kanugula SS, Sudhir S, et al. The role of cancer-associated fibroblasts in tumor progression[J]. Cancers, 2021, 13(6): 1399.
12 Elyada E, Bolisetty M, Laise P, et al. Cross-species single-cell analysis of pancreatic ductal adenocarcinoma reveals antigen-presenting cancer-associated fibroblasts[J]. Cancer Discov, 2019, 9(8): 1102-1123.
13 Öhlund D, Handly-Santana A, Biffi G, et al. Distinct populations of inflammatory fibroblasts and myofibroblasts in pancreatic cancer[J]. J Exp Med, 2017, 214(3): 579-596.
14 Han CC, Liu TY, Yin R. Biomarkers for cancer-associated fibroblasts[J]. Biomark Res, 2020, 8(1): 64.
15 Zhang JY, Zhu WW, Wang MY, et al. Cancer-asso-ciated fibroblasts promote oral squamous cell carcinoma progression through LOX-mediated matrix stiffness[J]. J Transl Med, 2021, 19(1): 513.
16 Kim DK, Kim EK, Jung DW, et al. Cytoskeletal alteration modulates cancer cell invasion through RhoA-YAP signaling in stromal fibroblasts[J]. PLoS One, 2019, 14(3): e0214553.
17 Grasset EM, Bertero T, Bozec A, et al. Matrix stif-fening and EGFR cooperate to promote the collective invasion of cancer cells[J]. Cancer Res, 2018, 78(18): 5229-5242.
18 Karakasheva TA, Lin EW, Tang QS, et al. IL-6 mediates cross-talk between tumor cells and activated fibroblasts in the tumor microenvironment[J]. Cancer Res, 2018, 78(17): 4957-4970.
19 Erdogan B, Webb DJ. Cancer-associated fibroblasts modulate growth factor signaling and extracellular matrix remodeling to regulate tumor metastasis[J]. Biochem Soc Trans, 2017, 45(1): 229-236.
20 Najafi M, Farhood B, Mortezaee K. Extracellular matrix (ECM) stiffness and degradation as cancer drivers[J]. J Cell Biochem, 2019, 120(3): 2782-2790.
21 Kumar D, Kandl C, Hamilton CD, et al. Mitigation of tumor-associated fibroblast-facilitated head and neck cancer progression with anti-hepatocyte grow-th factor antibody ficlatuzumab[J]. JAMA Otolaryngol Head Neck Surg, 2015, 141(12): 1133-1139.
22 Yoshimatsu Y, Wakabayashi I, Kimuro S, et al. TNF-α enhances TGF‑β‑induced endothelial-to-mesenchymal transition via TGF‑β signal augmentation[J]. Cancer Sci, 2020, 111(7): 2385-2399.
23 Zhang XL, Hwang YS. Cancer-associated fibroblast stimulates cancer cell invasion in an interleukin-1 receptor (IL-1R)‑dependent manner[J]. Oncol Lett, 2019, 18(5): 4645-4650.
24 Li ZZ, Sun CJ, Qin ZH. Metabolic reprogramming of cancer-associated fibroblasts and its effect on cancer cell reprogramming[J]. Theranostics, 2021, 11(17): 8322-8336.
25 Warburg O, Wind F, Negelein E. The metabolism of tumors in the body[J]. J Gen Physiol, 1927, 8(6): 519-530.
26 Li X, Jiang EH, Zhao H, et al. Glycometabolic reprogramming-mediated proangiogenic phenotype enhancement of cancer-associated fibroblasts in oral squamous cell carcinoma: role of PGC-1α/PFKFB3 axis[J]. Br J Cancer, 2022, 127(3): 449-461.
27 Yang J, Shi XK, Yang M, et al. Glycolysis reprogramming in cancer-associated fibroblasts promotes the growth of oral cancer through the lncRNA H19/miR-675-5p/PFKFB3 signaling pathway[J]. Int J Oral Sci, 2021, 13(1): 12.
28 Xiao L, Hu QN, Peng YS, et al. TRAP1 suppresses oral squamous cell carcinoma progression by redu-cing oxidative phosphorylation metabolism of Cancer-associated fibroblasts[J]. BMC Cancer, 2021, 21(1): 1329.
29 Zhang XX, Dong YC, Zhao MX, et al. ITGB2-me-diated metabolic switch in CAFs promotes OSCC proliferation by oxidation of NADH in mitochon-drial oxidative phosphorylation system[J]. Theranostics, 2020, 10(26): 12044-12059.
30 Yang LF, Achreja A, Yeung TL, et al. Targeting stromal glutamine synthetase in tumors disrupts tumor microenvironment-regulated cancer cell growth[J]. Cell Metab, 2016, 24(5): 685-700.
31 Gong J, Lin YY, Zhang HQ, et al. Reprogramming of lipid metabolism in cancer-associated fibroblasts potentiates migration of colorectal cancer cells[J]. Cell Death Dis, 2020, 11(4): 267.
32 Huang TX, Tan XY, Huang HS, et al. Targeting cancer-associated fibroblast-secreted WNT2 restores dendritic cell-mediated antitumour immunity[J]. Gut, 2022, 71(2): 333-344.
33 Huang YH, Chang CY, Kuo YZ, et al. Cancer-associated fibroblast-derived interleukin-1β activates protumor C-C motif chemokine ligand 22 signaling in head and neck cancer[J]. Cancer Sci, 2019, 110(9): 2783-2793.
34 Zhao XX, Ding L, Lu ZY, et al. Diminished CD68+ cancer-associated fibroblast subset induces regulatory T-cell (treg) infiltration and predicts poor prognosis of oral squamous cell carcinoma patients[J]. Am J Pathol, 2020, 190(4): 886-899.
35 Li X, Bu WH, Meng L, et al. CXCL12/CXCR4 pathway orchestrates CSC-like properties by CAF recruited tumor associated macrophage in OSCC[J]. Exp Cell Res, 2019, 378(2): 131-138.
36 Xie JQ, Qi XF, Wang YF, et al. Cancer-associated fibroblasts secrete hypoxia-induced serglycin to promote head and neck squamous cell carcinoma tumor cell growth in vitro and in vivo by activating the Wnt/β-catenin pathway[J]. Cell Oncol, 2021, 44(3): 661-671.
37 Kumar D, New J, Vishwakarma V, et al. Cancer-associated fibroblasts drive glycolysis in a targetable signaling loop implicated in head and neck squamous cell carcinoma progression[J]. Cancer Res, 2018, 78(14): 3769-3782.
38 Qin X, Yan M, Wang X, et al. Cancer-associated fibroblast-derived IL-6 promotes head and neck cancer progression via the osteopontin-NF-kappa B signaling pathway[J]. Theranostics, 2018, 8(4): 921-940.
39 Wei LY, Lee JJ, Yeh CY, et al. Reciprocal activation of cancer-associated fibroblasts and oral squamous carcinoma cells through CXCL1[J]. Oral Oncol, 2019, 88: 115-123.
40 Sun LP, Xu K, Cui J, et al. Cancer‑associated fibroblast‑derived exosomal miR‑382‑5p promotes the migration and invasion of oral squamous cell carcinoma[J]. Oncol Rep, 2019, 42(4): 1319-1328.
41 Zhu GQ, Cao BR, Liang XH, et al. Small extracellular vesicles containing miR-192/215 mediate hypo-xia-induced cancer-associated fibroblast development in head and neck squamous cell carcinoma[J]. Cancer Lett, 2021, 506: 11-22.
42 Li J, Liu X, Zang SZ, et al. Small extracellular vesicle-bound vascular endothelial growth factor secre-ted by carcinoma-associated fibroblasts promotes angiogenesis in a bevacizumab-resistant manner[J]. Cancer Lett, 2020, 492: 71-83.
43 Kayamori K, Katsube K, Sakamoto K, et al. NOTCH3 is induced in cancer-associated fibroblasts and promotes angiogenesis in oral squamous cell carcinoma[J]. PLoS One, 2016, 11(4): e0154112.
44 Liao JK, Zhou B, Zhuang XM, et al. Cancer-asso-ciated fibroblasts confer cisplatin resistance of tongue cancer via autophagy activation[J]. Biomed Pharmacother, 2018, 97: 1341-1348.
45 Zhang DY, Ding L, Li Y, et al. Midkine derived from cancer-associated fibroblasts promotes cispla-tin-resistance via up-regulation of the expression of lncRNA ANRIL in tumour cells[J]. Sci Rep, 2017, 7(1): 16231.
46 Chen JH, Wu ATH, Bamodu OA, et al. Ovatodiolide suppresses oral cancer malignancy by down-regula-ting exosomal mir-21/STAT3/β‑catenin cargo and preventing oncogenic transformation of normal gingival fibroblasts[J]. Cancers, 2019, 12(1): 56.
47 Qin X, Guo HY, Wang XN, et al. Exosomal miR-196a derived from cancer-associated fibroblasts confers cisplatin resistance in head and neck cancer through targeting CDKN1B and ING5[J]. Genome Biol, 2019, 20(1): 12.
48 Wu FL, Yang J, Liu JJ, et al. Signaling pathways in cancer-associated fibroblasts and targeted therapy for cancer[J]. Signal Transduct Target Ther, 2021, 6(1): 218.
49 Wang YX, Xie DY, Pan JR, et al. A near infrared light-triggered human serum albumin drug delivery system with coordination bonding of indocyanine green and cisplatin for targeting photochemistry therapy against oral squamous cell cancer[J]. Biomater Sci, 2019, 7(12): 5270-5282.
50 Wu FL, Wang SM, Zeng QX, et al. TGF-βRⅡ regulates glucose metabolism in oral cancer-associated fibroblasts via promoting PKM2 nuclear translocation[J]. Cell Death Discov, 2022, 8(1): 3.
51 Wang Q, Zhang YC, Zhu LF, et al. Heat shock factor 1 in cancer-associated fibroblasts is a potential prognostic factor and drives progression of oral squamous cell carcinoma[J]. Cancer Sci, 2019, 110(5): 1790-1803.
52 Hanley CJ, Mellone M, Ford K, et al. Targeting the myofibroblastic cancer-associated fibroblast phenotype through inhibition of NOX4[J]. J Natl Cancer Inst, 2018, 110(1): 109-120.
53 Xia CW, Pan JR, Wang JQ, et al. Functional bloc-kade of cancer-associated fibroblasts with ultrafine gold nanomaterials causes an unprecedented bystander antitumoral effect[J]. Nanoscale, 2020, 12(38): 19833-19843.
54 Ko YC, Lai TY, Hsu SC, et al. Index of cancer-associated fibroblasts is superior to the epithelial-mesenchymal transition score in prognosis prediction[J]. Cancers, 2020, 12(7): 1718.
55 Custódio M, Biddle A, Tavassoli M. Portrait of a CAF: the story of cancer-associated fibroblasts in head and neck cancer[J]. Oral Oncol, 2020, 110: 104972.
[1] Zhou Jinkuo,Zhang Jinhong,Shi Xiaojing,Liu Guangshun,Jiang Lei,Liu Qianfeng. Influences of long noncoding RNA small nucleolar RNA host gene 22 on the cell proliferation, invasion and migration of oral squamous carcinoma cells by regulating microRNA-27b-3p [J]. Int J Stomatol, 2024, 51(1): 52-59.
[2] Li Liheng,Wang Rui,Wang Xiaoming,Zhang Zhiyi,Zhang Xuan,An Feng,Wang Qin,Zhang Fan. Effects of circular RNA hsa_circ_0085576 on cell migration and invasion of oral squamous cell carcinoma by regulating the microRNA-498/B-cell-specific Moloney murine leukemia virus integration site 1 axis [J]. Int J Stomatol, 2024, 51(1): 60-67.
[3] Liu Jianglong, Tuerdi Maimaitituxun. Progress of contrast-enhanced ultrasound in the diagnosis of cervical lymph node metastasis from oral squamous cell carcinoma [J]. Int J Stomatol, 2023, 50(5): 514-520.
[4] Sheng Nanning,Wang Jue,Nan Xinrong. Research progress on mechanism and treatment of sex-determining region Y box 9 in oral squamous cell carcinoma [J]. Int J Stomatol, 2023, 50(3): 314-320.
[5] Li Tan,Liang Xin-hua.. Role of discoidin domain receptor 1 in the regulation of malignant tumor progression and therapy [J]. Int J Stomatol, 2023, 50(2): 230-236.
[6] Zhao Zhuoping,Xin Pengfei,Gao Yang,Zhang Caifeng,Zhang Kuanshou,Liu Qingmei. Research progress on the use of photothermal therapy to treat oral squamous cell carcinoma [J]. Int J Stomatol, 2022, 49(4): 462-470.
[7] Jiang Han,Shen Yingqiang,Chen Qianming. Experimental study of muscarinic receptors on the biological behavior of oral squamous cell carcinoma through Yes related protein signal [J]. Int J Stomatol, 2022, 49(2): 138-143.
[8] Jiang Yulei,Xia Bin,Rao Nanquan,Yang Hefeng,Xu Biao. Exosomes mediate the malignant progression of oral squamous cell carcinoma and its application in diagnosis and treatment [J]. Int J Stomatol, 2021, 48(6): 711-717.
[9] Gan Jianguo,Gao Pan,Wang Xiaoyi. Research progress on the relationship between circulating tumor cells and oral squamous cell carcinoma [J]. Int J Stomatol, 2021, 48(2): 205-212.
[10] Huang Junwen,Qiao Jie,Mei Zi,Chen Zhuo,Li Yang,Qiao Bin. Expression and clinical significance of lipopolysaccharide binding protein in oral squamous cell carcinoma [J]. Int J Stomatol, 2021, 48(1): 50-57.
[11] He Yuqing,Dan Hongxia,Chen Qianming. Application of photodynamic therapy for oral carcinogenesis prevention [J]. Int J Stomatol, 2020, 47(6): 669-676.
[12] Hao Fu,Ning Yi,Sun Rui,Zheng Xiaoxu. Expression and potential clinical significance of Transformer 2β in oral squamous cell carcinoma [J]. Int J Stomatol, 2020, 47(2): 159-165.
[13] Xue Lingli,Li Yadong. Survival analysis of patients with oral squamous cell carcinoma treated by radical surgery for the first time [J]. Int J Stomatol, 2020, 47(2): 166-174.
[14] Chen Hongli,Yang Jing,Yin Gang,Li Haoyuan,Qiao Yan. Expression of zinc finger protein 32 in oral squamous cell carcinoma and its effect on oral squamous cell carcinoma stem cells [J]. Int J Stomatol, 2019, 46(6): 631-639.
[15] Bing Yan,Xianyang Luo,Yingyun Tan,Limei Guan,Lili Xue. Research on the surface-enhanced Raman spectrum of blood serum for clinical staging of oral squamous cell carcinoma [J]. Int J Stomatol, 2019, 46(3): 277-281.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[2] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[3] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[4] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[5] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[6] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[7] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[8] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[9] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[10] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .