Int J Stomatol ›› 2023, Vol. 50 ›› Issue (6): 711-717.doi: 10.7518/gjkq.2023110

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Research progress on cancer-associated fibroblasts in the tumor microenvironment of oral squamous cell carcinoma

Wu Jiamin(),Xia Bin,Yang Hefeng,Xu Biao.()   

  1. Dept. of Oral and Maxillofacial Surgery, Affiliated Stomatological Hospital of Kunming Medical University, Kunming 650500, China
  • Received:2023-03-25 Revised:2023-07-26 Online:2023-11-01 Published:2023-10-24
  • Contact: Biao. Xu;
  • Supported by:
    Yunnan Provincial Key Laboratory of Stomatology(202005AG070041);Yunnan Provincial Health Commission Internal Institutions Project(2018NS0210)


Cancer-associated fibroblasts are the most abundant stromal cells in the tumor microenvironment. An increasing number of studies have found that cancer-associated fibroblasts play a remarkable role in the development of tumors. Cancer-associated fibroblasts remodel the extracellular matrix, regulate tumor metabolism, and participate in immune regulation, and promote tumor growth, angiogenesis, migration, and invasion. Therefore, disrupting the interaction between cancer-associated fibroblasts and the surrounding environment may provide us with new therapeutic ideas. In this paper, we will review the research progress on cancer-associated fibroblasts in oral squamous carcinoma.

Key words: cancer-associated fibroblast, oral squamous cell carcinoma, tumor microenvironment

CLC Number: 

  • R 739.81

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