Int J Stomatol ›› 2023, Vol. 50 ›› Issue (5): 514-520.doi: 10.7518/gjkq.2023088

• Oral Oncology • Previous Articles     Next Articles

Progress of contrast-enhanced ultrasound in the diagnosis of cervical lymph node metastasis from oral squamous cell carcinoma

Liu Jianglong1(),Tuerdi Maimaitituxun1,2()   

  1. 1.Dept. of Oral and Maxillofacial Trauma and Orthognathic Surgery, First Affiliated Hospital (Stomatological Hospital) of Xinjiang Medical University, Urumqi 830054, China
    2.Institute of Stomatology, Xinjiang Uygur Autonomous Region, Urumqi 830054, China
  • Received:2022-10-22 Revised:2023-01-05 Online:2023-09-01 Published:2023-09-01
  • Contact: Maimaitituxun Tuerdi E-mail:liujianglong422@126.com;tuxun@aliyun.com

Abstract:

Squamous cell carcinoma is the most common pathological type of oral cancer and is one of the diseases that seriously endanger human oral health. It is characterized by a high degree of local aggressiveness and the occurrence of cervical lymph node metastases. Conventional ultrasound is a common clinical examination method for the diagnosis of metastatic lymph nodes in the neck. Contrast-enhanced ultrasound is an ultrasound imaging tool that can evaluate microcirculatory perfusion in lymph nodes in real time for the visualization of blood flow in lymph nodes and the diagnosis of benign and malignant lymph nodes using qualitative and quantitative parameters. With the development and popularity of contrast-enhanced ultrasound, it has been increasingly applied in the diagnosis of cervical lymph node metastasis from oral squamous cell carcinoma. In this work, we searched relevant studies published in domestic and international data-bases and reviewed the application of contrast-enhanced ultrasound in the diagnosis of cervical lymph node metastasis from oral squamous cell carcinoma the detection of sentinel lymph node and the imaging with nano-scale contrast-enhanced ultrasound, in order to provide a rapid, economical, and reliable diagnostic method for clinical practice.

Key words: contrast-enhanced ultrasound, oral squamous cell carcinoma, cervical lymph node metastasis

CLC Number: 

  • R 739.8

TrendMD: 
1 Rivera C. Essentials of oral cancer[J]. Int J Clin Exp Pathol, 2015, 8(9): 11884-11894.
2 Yang Y, Zhou MG, Zeng XY, et al. The burden of oral cancer in China, 1990-2017: an analysis for the global burden of disease, injuries, and risk factors study 2017[J]. BMC Oral Health, 2021, 21(1): 44.
3 Arun I, Maity N, Hameed S, et al. Lymph node cha-racteristics and their prognostic significance in oral squamous cell carcinoma[J]. Head Neck, 2021, 43(2): 520-533.
4 Mahieu R, de Maar JS, Nieuwenhuis ER, et al. New developments in imaging for sentinel lymph node biopsy in early-stage oral cavity squamous cell carcinoma[J]. Cancers (Basel), 2020, 12(10): 3055.
5 Ling WW, Nie J, Zhang DY, et al. Role of contrast-enhanced ultrasound (CEUS) in the diagnosis of cervical lymph node metastasis in nasopharyngeal carcinoma (NPC) patients[J]. Front Oncol, 2020, 10: 972.
6 Yu M, Liu Q, Song HP, et al. Clinical application of contrast-enhanced ultrasonography in diagnosis of superficial lymphadenopathy[J]. J Ultrasound Med, 2010, 29(5): 735-740.
7 Li QL, Ma T, Wang ZJ, et al. The value of contrast-enhanced ultrasound for the diagnosis of metastatic cervical lymph nodes of papillary thyroid carcinoma: a systematic review and meta-analysis[J]. J Clin Ultrasound, 2022, 50(1): 60-69.
8 Dietrich CF, Bolondi L, Duck F, et al. History of Ultrasound in Medicine from its birth to date (2022), on occasion of the 50 Years Anniversary of EFSUMB. A publication of the European Federation of Societies for Ultrasound In Medicine and Biology (EFSUMB), designed to record the historical deve-lopment of medical ultrasound[J]. Med Ultrason, 2022, 24(4): 434-450.
9 Gramiak R, Shah PM, Kramer DH. Ultrasound cardiography: contrast studies in anatomy and function[J]. Radiology, 1969, 92(5): 939-948.
10 李华梅, 张东生. 超声微泡造影剂在肿瘤诊断与治疗中的研究进展[J]. 东南大学学报(医学版), 2009, 28(5): 435-438.
Li HM, Zhang DS. Research progress of ultrasound microbubble contrast agents in tumor diagnosis and treatment[J]. J Southeast Univ (Med Sci Edi), 2009, 28(5): 435-438.
11 Cui QX, Dai L, Li JL, et al. Accuracy of CEUS-guided sentinel lymph node biopsy in early-stage breast cancer: a study review and meta-analysis[J]. World J Surg Oncol, 2020, 18(1): 112.
12 Gillot L, Baudin L, Rouaud L, et al. The pre-metastatic niche in lymph nodes: Formation and characteristics[J]. Cell Mol Life Sci, 2021, 78(16): 5987-6002.
13 Hylton DA, Turner S, Kidane B, et al. The Canada Lymph Node Score for prediction of malignancy in mediastinal lymph nodes during endobronchial ultrasound[J]. J Thorac Cardiovasc Surg, 2020, 159(6): 2499-2507.e3.
14 王尚, 陈文卫. 超声诊断颈部转移性淋巴结的应用进展[J]. 临床超声医学杂志, 2018, 20(10): 698-700.
Wang S, Chen WW. Progress of ultrasound in diagnosis of metastatic cervical lymph nodes[J]. J Clin Ultrasound Med, 2018, 20(10): 698-700.
15 黄星月, 陈辽, 李蓬, 等. 超声造影在颈部淋巴结鉴别诊断中的应用价值[J]. 中华超声影像学杂志, 2015, 24(12): 1051-1055.
Huang XY, Chen L, Li P, et al. Application of contrast-enhanced ultrasound in differential diagnosis of cervical lymph nodes[J]. Chin J Ultrasonogr, 2015, 24(12): 1051-1055.
16 崔秋丽, 尹珊珊, 范智慧, 等. 颈部增大淋巴结超声造影灌注特点及时间-强度曲线参数分析[J]. 中国超声医学杂志, 2017, 33(1): 4-7.
Cui QL, Yin SS, Fan ZH, et al. Perfusion characte-ristics and parameters of time intensity curve with contrast-enhanced ultrasound in the diagnosis of cervical lymph nodes[J]. Chin J Ultrasound Med, 2017, 33(1): 4-7.
17 Xiang DP, Hong YR, Zhang B, et al. Contrast-enhanced ultrasound (CEUS) facilitated US in detec-ting lateral neck lymph node metastasis of thyroid cancer patients: diagnosis value and enhancement patterns of malignant lymph nodes[J]. Eur Radiol, 2014, 24(10): 2513-2519.
18 Ding Z, Deng C, Wang Z, et al. Comparison of contrast-enhanced ultrasound and contrast-enhanced computed tomography for the diagnosis of cervical lymph node metastasis in squamous cell carcinoma of the oral cavity[J]. Int J Oral Maxillofac Surg, 2021, 50(3): 294-301.
19 赵建广, 陈彦平, 杨蕾, 等. 应用声诺维超声造影诊断口腔癌颈淋巴结转移的临床探讨[J]. 北京口腔医学, 2015, 23(1): 36-39.
Zhao JG, Chen YP, Yang L, et al. The application of SonoVue enhanced ultrasonography in diagnosis of cervical lymph node metastasis in oral squamous cell carcinoma[J]. Beijing J Stomatol, 2015, 23(1): 36-39.
20 Cui QL, Yin SS, Fan ZH, et al. Diagnostic value of contrast-enhanced ultrasonography and time-intensity curve in differential diagnosis of cervical metastatic and tuberculous lymph nodes[J]. J Ultrasound Med, 2018, 37(1): 83-92.
21 张琦, 朱天彤, 庄连婷, 等. 超声造影定量分析在鉴别颈部淋巴结良恶性的应用研究[J]. 中国临床医学影像杂志, 2021, 32(6): 393-397.
Zhang Q, Zhu TT, Zhuang LT, et al. Quantitative analysis of contrast-enhanced ultrasound in differential diagnosis of benign and malignant cervical lymph nodes[J]. J Chin Clin Med Imag, 2021, 32(6): 393-397.
22 Luo ZY, Hong YR, Yan CX, et al. Utility of quantitative contrast-enhanced ultrasound for the prediction of lymph node metastasis in patients with papillary thyroid carcinoma[J]. Clin Hemorheol Microcirc, 2022, 80(1): 37-48.
23 Chen L, Chen LZ, Liu JH, et al. Value of qualitative and quantitative contrast-enhanced ultrasound analysis in preoperative diagnosis of cervical lymph node metastasis from papillary thyroid carcinoma[J]. J Ultrasound Med, 2020, 39(1): 73-81.
24 Ding SW, Xiong P, Zuo JX. Value of contrast-enhanced ultrasound in predicting early lymph-node metastasis in oral cancer[J]. Dentomaxillofac Ra-diol, 2022, 51(3): 20210293.
25 Sohn B, Koh YW, Kang WJ, et al. Is there an additive value of 18 F-FDG PET-CT to CT/MRI for detecting nodal metastasis in oropharyngeal squamous cell carcinoma patients with palpably negative neck[J]. Acta Radiol, 2016, 57(11): 1352-1359.
26 Liao LJ, Lo WC, Hsu WL, et al. Detection of cervical lymph node metastasis in head and neck cancer patients with clinically N0 neck-a meta-analysis comparing different imaging modalities[J]. BMC Cancer, 2012, 12: 236.
27 de Souza Figueiredo PT, Leite AF, Barra FR, et al. Contrast-enhanced CT and MRI for detecting neck metastasis of oral cancer: comparison between ana-lyses performed by oral and medical radiologists[J]. Dentomaxillofac Radiol, 2012, 41(5): 396-404.
28 Qureshi TA, Wasif M, Awan MS, et al. Role of contrast enhanced computed tomography in assessing cervical lymph node metastases in oral cavity squamous cell carcinoma[J]. J Pak Med Assoc, 2021, 71(3): 826-829.
29 Sumi M, Ohki M, Nakamura T. Comparison of sonography and CT for differentiating benign from malignant cervical lymph nodes in patients with squamous cell carcinoma of the head and neck[J]. AJR Am J Roentgenol, 2001, 176(4): 1019-1024.
30 de Bree R, Nieweg OE. The history of sentinel node biopsy in head and neck cancer: from visualization of lymphatic vessels to sentinel nodes[J]. Oral Oncol, 2015, 51(9): 819-823.
31 Matoba N, Kikuchi T. Thyroidolymphography. A new technic for visualization of the thyroid and cervical lymph nodes[J]. Radiology, 1969, 92(2): 339-342.
32 Civantos FJ, Stoeckli SJ, Takes RP, et al. What is the role of sentinel lymph node biopsy in the ma-nagement of oral cancer in 2010[J]. Eur Arch Otorhinolaryngol, 2010, 267(6): 839-844.
33 Wakisaka N, Endo K, Kitazawa T, et al. Detection of sentinel lymph node using contrast-enhanced agent, SonazoidTM, and evaluation of its metastasis with superb microvascular imaging in oral and oropharyngeal cancers: a preliminary clinical study[J]. Acta Otolaryngol, 2019, 139(1): 94-99.
34 毛煌兴, 龙瀛, 盛小伍, 等. 近红外荧光显影技术在口腔癌诊疗中的应用进展[J]. 中南大学学报(医学版), 2021, 46(3): 316-321.
Mao HX, Long Y, Sheng XW, et al. Progress in application of near-infrared fluorescence imaging in the diagnosis and treatment of oral cancer[J]. J Cent South Univ (Med Sci), 2021, 46(3): 316-321.
35 Sever A, Jones S, Cox K, et al. Preoperative loca-lization of sentinel lymph nodes using intradermal microbubbles and contrast-enhanced ultrasonography in patients with breast cancer[J]. Br J Surg, 2009, 96(11): 1295-1299.
36 王云月, 阮骊韬, 任予, 等. CEUS诊断乳腺癌研究进展[J]. 中国医学影像技术, 2018, 34(4): 633-636.
Wang YY, Ruan LT, Ren Y, et al. Progresses of CEUS in diagnosis of breast cancers[J]. Chin J Med Imag Technol, 2018, 34(4): 633-636.
37 Gvetadze SR, Xiong P, Lv M, et al. Contrast-enhanced ultrasound mapping of sentinel lymph nodes in oral tongue cancer-a pilot study[J]. Dentomaxillofac Radiol, 2017, 46(3): 20160345.
38 Huang J, Wu SS, Zheng S, et al. Trans-lymphatic contrast-enhanced ultrasound with sentinel lymph node biopsy for detecting cervical skip metastasis to lymph nodes in early-stage oral tongue squamous cell carcinoma[J]. Dentomaxillofac Radiol, 2022, 51(2): 20210107.
39 Fan XZ, Wang LF, Guo YL, et al. Inhibition of prostate cancer growth using doxorubicin assisted by ultrasound-targeted nanobubble destruction[J]. Int J Nanomedicine, 2016, 11: 3585-3596.
40 Wang F, Wang Z, Pang L, et al. Preparation and in vitro study of stromal cell-derived factor 1-targeted Fe3O4/poly(lactic-co-glycolic acid)/perfluorohexane nanoparticles[J]. Exp Ther Med, 2020, 20(3): 2003-2012.
41 万书良, 王菲, 熊均, 等. 载SDF-1纳米粒造影剂在兔舌癌颈部转移淋巴结成像的应用以及治疗作用的初步研究[J]. 现代口腔医学杂志, 2020, 34(4): 193-196.
Wan SL, Wang F, Xiong J, et al. The application of imaging for SDF-1-loaded nanoparticles contrast agents and preliminary study on its therapeutic effect in metastatic lymph nodes in tongue squamous cell carcinoma of rabbit[J]. J Modern Stomatol, 2020, 34(4): 193-196.
42 Sun IC, Jo S, Dumani D, et al. Theragnostic glycol chitosan-conjugated gold nanoparticles for photoacoustic imaging of regional lymph nodes and deli-vering tumor antigen to lymph nodes[J]. Nanomaterials (Basel), 2021, 11(7): 1700.
43 Zhang G, Ye HR, Sun Y, et al. Ultrasound molecular imaging and its applications in cancer diagnosis and therapy[J]. ACS Sens, 2022, 7(10): 2857-2864.
44 Liu CH, Sastre A, Conroy R, et al. NIH workshop on clinical translation of molecular imaging probes and technology: meeting report[J]. Mol Imaging Biol, 2014, 16(5): 595-604.
45 Sidhu PS, Cantisani V, Dietrich CF, et al. The EFSUMB guidelines and recommendations for the cli-nical practice of contrast-enhanced ultrasound (CEUS) in non-hepatic applications: update 2017 (short version)[J]. ultraschall Med, 2018, 39(2): 154-180.
[1] Zhou Jinkuo,Zhang Jinhong,Shi Xiaojing,Liu Guangshun,Jiang Lei,Liu Qianfeng. Influences of long noncoding RNA small nucleolar RNA host gene 22 on the cell proliferation, invasion and migration of oral squamous carcinoma cells by regulating microRNA-27b-3p [J]. Int J Stomatol, 2024, 51(1): 52-59.
[2] Li Liheng,Wang Rui,Wang Xiaoming,Zhang Zhiyi,Zhang Xuan,An Feng,Wang Qin,Zhang Fan. Effects of circular RNA hsa_circ_0085576 on cell migration and invasion of oral squamous cell carcinoma by regulating the microRNA-498/B-cell-specific Moloney murine leukemia virus integration site 1 axis [J]. Int J Stomatol, 2024, 51(1): 60-67.
[3] Wu Jiamin,Xia Bin,Yang Hefeng,Xu Biao.. Research progress on cancer-associated fibroblasts in the tumor microenvironment of oral squamous cell carcinoma [J]. Int J Stomatol, 2023, 50(6): 711-717.
[4] Sheng Nanning,Wang Jue,Nan Xinrong. Research progress on mechanism and treatment of sex-determining region Y box 9 in oral squamous cell carcinoma [J]. Int J Stomatol, 2023, 50(3): 314-320.
[5] Li Tan,Liang Xin-hua.. Role of discoidin domain receptor 1 in the regulation of malignant tumor progression and therapy [J]. Int J Stomatol, 2023, 50(2): 230-236.
[6] Zhao Zhuoping,Xin Pengfei,Gao Yang,Zhang Caifeng,Zhang Kuanshou,Liu Qingmei. Research progress on the use of photothermal therapy to treat oral squamous cell carcinoma [J]. Int J Stomatol, 2022, 49(4): 462-470.
[7] Jiang Han,Shen Yingqiang,Chen Qianming. Experimental study of muscarinic receptors on the biological behavior of oral squamous cell carcinoma through Yes related protein signal [J]. Int J Stomatol, 2022, 49(2): 138-143.
[8] Jiang Yulei,Xia Bin,Rao Nanquan,Yang Hefeng,Xu Biao. Exosomes mediate the malignant progression of oral squamous cell carcinoma and its application in diagnosis and treatment [J]. Int J Stomatol, 2021, 48(6): 711-717.
[9] Li Shan,Chen Linlin. Treatment of patients with negative cervical lymph nodes in maxillary squamous cell carcinoma [J]. Int J Stomatol, 2021, 48(4): 444-449.
[10] Li Ming,Yuan Zhenying,Nan Xinrong. Correlation between the depth of invasion measured by magnetic resonance imaging and cervical lymph node metastasis in patients with tongue squamous cell carcinoma [J]. Int J Stomatol, 2021, 48(3): 312-317.
[11] Gan Jianguo,Gao Pan,Wang Xiaoyi. Research progress on the relationship between circulating tumor cells and oral squamous cell carcinoma [J]. Int J Stomatol, 2021, 48(2): 205-212.
[12] Huang Junwen,Qiao Jie,Mei Zi,Chen Zhuo,Li Yang,Qiao Bin. Expression and clinical significance of lipopolysaccharide binding protein in oral squamous cell carcinoma [J]. Int J Stomatol, 2021, 48(1): 50-57.
[13] He Yuqing,Dan Hongxia,Chen Qianming. Application of photodynamic therapy for oral carcinogenesis prevention [J]. Int J Stomatol, 2020, 47(6): 669-676.
[14] Hao Fu,Ning Yi,Sun Rui,Zheng Xiaoxu. Expression and potential clinical significance of Transformer 2β in oral squamous cell carcinoma [J]. Int J Stomatol, 2020, 47(2): 159-165.
[15] Xue Lingli,Li Yadong. Survival analysis of patients with oral squamous cell carcinoma treated by radical surgery for the first time [J]. Int J Stomatol, 2020, 47(2): 166-174.
Viewed
Full text


Abstract

Cited

  Shared   
  Discussed   
[1] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[2] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[3] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[4] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[5] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[6] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[7] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[8] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[9] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[10] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .