Int J Stomatol ›› 2019, Vol. 46 ›› Issue (6): 675-679.doi: 10.7518/gjkq.2019097

• Reviews • Previous Articles     Next Articles

Advances of dental pulp stem cells in osteogenic microenvironment

Zhou Tingru1,2,Li Yongsheng2()   

  1. 1. School of Stomatology, Kunming Medical University, Kunming 650032, China
    2. Dept. of Oral and Maxillofacial Surgery, Yunnan First People’s Hospital, Kunming 650032, China;
  • Received:2019-02-10 Revised:2019-08-19 Online:2019-11-01 Published:2019-11-14
  • Contact: Yongsheng Li
  • Supported by:
    This study was supported by Yunnan Provincial Department of Science and Technology-Kunming Medical University Joint Research Fundamental Research Project(2017FE467-209)


Dental pulp stem cells possess high proliferation rates and multi-lineage differentiation potential. These features provide them with unique advantages and prospects in the repair of oral and maxillofacial bone tissue with bio-scaffold materials. Hence, dental pulp stem cells are optimised cells in bone tissue engineering. To enhance the regeneration of bone tissue, a suitable microenvironment is necessary for the osteogenic differentiation of dental pulp stem cells. In this review, we will examine the research progress of cytokines, scaffolds and drugs of dental pulp stem cells in an osteogenic microenvironment.

Key words: dental pulp stem cell, osteogenic differentiation, cytokine, scaffold, drug

CLC Number: 

  • Q254

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