Int J Stomatol ›› 2023, Vol. 50 ›› Issue (1): 32-36.doi: 10.7518/gjkq.2023010

• Periodontitis • Previous Articles     Next Articles

Research progress on innate lymphoid cells in periodontal diseases

Cheng Yifan(),Qin Xu,Jiang Ming,Zhu Guang-xun.()   

  1. Dept. of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Techno-logy, Wuhan 430030, China
  • Received:2022-02-25 Revised:2022-08-02 Online:2023-01-01 Published:2023-01-09
  • Contact: Guang-xun. Zhu;
  • Supported by:
    National Natural Science Foundation of China(81300883);Natural Science Foundation of Hubei Province of China(2019CFB688)


Innate lymphoid cells (ILCs) are a member of innate immune cells, which bridge the innate and adaptive immunities. ILCs are mainly distributed at mucosal barriers and participate in defense against pathogens, the repair of tissue, the maintenance of tissue integrity, and the formation of the lymphoid organ. They have been studied extensively in lungs and gastrointestinal tissues. On the basis of the expression of transcription factors, the secretion of cytokines, and the characteristics of functions, ILCs can be categorized into three subtypes: groups Ⅰ, Ⅱ and Ⅲ. With the constant deepening of the studies on ILCs, ILCs can now be classified into six subsets: natural killer cells, ILC1, ILC2, ILC3, lymphoid-tissue inducers, and regulatory innate lymphoid cells. ILCs are found in healthy and inflammatory periodontal tissue and that different subtypes play distinct roles in the occurrence and development of periodontal diseases. Therefore, these cells offer new strategies for the therapy of periodontal diseases. This article will review the classification and functions of ILCs, the characteristics of ILCs in periodontal tissue, and the roles of ILCs in periodontal diseases.

Key words: innate lymphoid cells, periodontal diseases, cytokines, immune response

CLC Number: 

  • R 781.4

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