Int J Stomatol

Inter J Stomatol ›› 2018, Vol. 45 ›› Issue (3): 335-339.doi: 10.7518/gjkq.2018.03.017

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Correlation between periodontal diseases and Alzheimer’s disease

Li Yihan, Pan Lanlan   

  1. School of Stomatology, Chongqing Medical University, Dept. of Periodontology, Stomatological Hospital, Chongqing Medical University, Chongqing Key Laboratory of Oral Diseases and Biomedical Sciences, Chongqing 401147, China
  • Received:2017-07-12 Revised:2018-01-29 Published:2018-05-08
  • Supported by:
    This study was supported by Chongqing Medical Research Project (2015MSXM050).

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Abstract: Alzheimer’s disease (AD) is a chronic, progressive and irreversible neurodegenerative disease. The prevalence of AD increases exponentially with age. Although the pathophysiologic mechanism is not fully understood, inflammation has been confirmedto play a critical role in the pathogenesis of AD. Chronic periodontitisis a chronic immuno-inflammatory disease initiated by complex polymicrobial subgingival biofilm. Periodontal pathogens are implicated in the development of a number of inflammatory pathologies at remote organ sites, including brain tissue where AD occurs. The objective of this review is to present the relationship and possible mechanistic links between periodontal disease and AD.

Key words: Alzheimer’s disease;, periodontitis, periodontal pathogen, cytokines, immune response

CLC Number: 

  • R781.4

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