Int J Stomatol ›› 2023, Vol. 50 ›› Issue (5): 587-593.doi: 10.7518/gjkq.2023087

• Reviews • Previous Articles     Next Articles

Research progress on the correlation between Parkinson’s disease and periodontitis

Gong Meiling(),Cheng Xingqun,Wu Hongkun.()   

  1. State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Geriatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2022-12-20 Revised:2023-05-27 Online:2023-09-01 Published:2023-09-01
  • Contact: Hongkun. Wu;
  • Supported by:
    Science and Technology Program for Overseas Students in Sichuan Province(2021-29-1);Research Funding from West China Hospital of Stomatology Sichuan University(RCDWJS2021-16)


Parkinson’s disease (PD) is a degenerative disease of nervous system that commonly occurs in the elderly. Chronic neuroinflammation is closely related to its pathophysiology. As one of the most common chronic inflammatory diseases, periodontitis can cause local and even systemic inflammation and is a risk factor for many systemic diseases. The correlation between PD and periodontitis is still unclear. Although no direct evidence confirms that periodontitis plays a role in the pathogenesis of PD, periodontitis may cause neuroinflammation through various ways and thus affect the occurrence of PD. This work reviews the research progress of PD and periodontitis to provide a theoretical basis for the prevention and treatment of oral and systemic chronic diseases.

Key words: Parkinson’s disease, periodontitis, neuroinflammation, neurodegenerative diseases, co-treatment of chronic diseases

CLC Number: 

  • R 781.4

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