Int J Stomatol ›› 2022, Vol. 49 ›› Issue (5): 593-599.doi: 10.7518/gjkq.2022085

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Progress in understanding the correlations between semaphorin 3A and common oral diseases

Chen Huiyu(),Bai Mingru,Ye Ling.()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2021-12-06 Revised:2022-04-06 Online:2022-09-01 Published:2022-09-16
  • Contact: Ling. Ye;
  • Supported by:
    National Natural Science Foundation of China Youth Science Foundation(82001020)


Semaphorin 3A (Sema3A) is a membrane-associated secreted protein produced by endothelial cells that regulate vascularization, cancer progression, bone biology, and immune homeostasis. Oral diseases are common and frequently occur in the human body. In recent years, an increasing number of studies have found that Sema3A expression changes with the progression of some common oral diseases. Sema3A inhibits apical periodontitis and pulpitis by inhibiting the expression of pro-inflammatory mediators to repress inflammation. In addition, it can also compete with vascular endothelial growth factors to bind its receptors to inhibit tumor angiogenesis. Oral diseases are represented by pulpitis, periodontitis, periapical periodontitis, dental dysplasia, and oral cancer. Exploring the role of Sema3A in oral diseases is of far-reaching significance for the comprehensive analysis of the molecular mechanisms in the diseases and the development of therapeutic drugs for intervention and treatment methods. In this paper, we will discuss the correlations between Sema3A and oral diseases and their molecular mechanisms.

Key words: semaphorin 3A, pulpitis, apical periodontitis, periodontitis, dental dysplasia, oral cancer

CLC Number: 

  • R 78

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