Int J Stomatol ›› 2023, Vol. 50 ›› Issue (4): 472-478.doi: 10.7518/gjkq.2023070

• Reviews • Previous Articles     Next Articles

Application of microneedles in stomatology

Fan Lin(),Sun Jiang.()   

  1. Dept. of Periodontal Mucosa, Dalian Stomatological Hospital, Dalian 116021, China
  • Received:2022-11-12 Revised:2023-04-04 Online:2023-07-01 Published:2023-06-21
  • Contact: Jiang. Sun;


Microneedles (MN) are transdermal drug delivery devices that can break through the oral mucosal barrier to deliver drugs into the body circulation through the oral and maxillofacial veins to exert drug effects. In addition, microneedles, when applied to the oral mucosa, can stimulate the body to immediately initiate a wound healing cascade response, stimulate the release of a variety of growth factors, promote vascular renewal and collagen and elastin synthesis to achieve tissue regeneration. Numerous studies have shown that microneedling is safe, painless, minimally invasive, and highly effective in drug delivery. At present, microneedling has been widely used in the fields of pharmacy and dermatology, and this paper reviews the application of microneedling in dentistry.

Key words: microneedle, oral mucosal administration, percutaneous collagen induction therapy, oral local anesthesia, oral cancer, periodontal tissue regeneration

CLC Number: 

  • R 782


Fig 1

Types of MN and its drug delivery mechanism"

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