Int J Stomatol

Inter J Stomatol ›› 2015, Vol. 42 ›› Issue (6): 668-672.doi: 10.7518/gjkq.2015.06.013

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Betel-quid chewing and its relationship with oral cancer

Shao Xiaojun, Xi Qing.   

  1. Dept. of Stomatology, Hainan Branch of People’s Liberation Army General Hospital, Sanya 572000, China
  • Received:2014-11-28 Revised:2015-05-24 Online:2015-11-01 Published:2015-11-01

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Abstract:

Betel-quid chewing is common in South Asia, South-east Asia, and the Pacific Islands, especially in our country. Betel-quid contains various ingredients, including areca-nut, tobacco, betel leaf, betel vine, inflorescence, slaked lime, and some special flavored substances. The composition and processing of betel-quid vary in different countries. However, areca-nut and tobacco are consistent main components. Areca-nut contains betel alkaloid, tannin betel nut, betel nut-specific nitrosamines, and reactive oxygen, which exerts cytotoxic, genotoxic, and carcinogen effects. Previous studies showed that betel-quid chewing is a significant factor contributing to oral submucous fibrosis and is related to the incidence of oral cancer, leukoplakia, lichen planus, and so on. This paper presents the prevalence of areca-nut consumption, ingredients, and carcinogenic mechanism to provide a scientific basis for oral cancer prevention and awareness.

Key words: areca-nut, betel-quid, precancerosis, oral cancer

CLC Number: 

  • R 739.85

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