Int J Stomatol ›› 2023, Vol. 50 ›› Issue (4): 407-413.doi: 10.7518/gjkq.2023068

• Oral Oncology • Previous Articles     Next Articles

Research progress on the application of near infrared fluorescence probe in the diagnosis of oral cancer

Jiang Yueying(),He Yutian,Li Ting,Zhou Ronghui.()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Oral and Maxillofacial Surgery, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2022-11-11 Revised:2023-02-02 Online:2023-07-01 Published:2023-06-21
  • Contact: Ronghui. Zhou;
  • Supported by:
    the National Science Fund for Distinguished Young Scholars(82102694)


Fluorescence imaging has attracted much attention in cancer diagnosis and drug targeting due to its advantages of low invasion, high sensitivity and real-time detection. Autofluorescence can be used to diagnose cancerous tissue by the difference of fluorescence generated by the same wavelength excitation light between pathological tissue and normal tissue, or to trace cancerous tissue by the fluorescence of the drug itself. However, the specificity and sensitivity of these fluorescence diagnostic techniques are poor. Compared with the existing fluorescence diagnosis methods, near-infrared fluorescence diagnosis technology is less interfered by background signals and can image deeper tissues, which can effectively make up for the deficiency of autofluorescence examination, and has important significance for the clinical diagnosis of oral cancer. Based on this, this paper reviews the construction methods of the first and second near-infrared fluorescent window imaging probes applied in the field of oral cancer diagnosis, and further discusses its research progress in the labeling of oral cancer, providing a reference for the real-time and accurate diagnosis of oral cancer.

Key words: oral cancer, near-infrared fluorescence, diagnosis, nanoprobe, molecular probe

CLC Number: 

  • R 782

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