Int J Stomatol

Int J Stomatol ›› 2023, Vol. 50 ›› Issue (5): 521-527.doi: 10.7518/gjkq.2023072

• Oral Oncology • Previous Articles     Next Articles

Research progress on the sentinel lymph nodes in the detection of head and neck squamous cell carcinoma

Li Yijun(),Xu Ziang,Li Yi.()   

  1. State Key Laboratory of Oral Diseases & National Center for Stomatology & National Clinical Research Center for Oral Diseases & Dept. of Head and Neck Oncology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2022-11-12 Revised:2023-04-16 Online:2023-09-01 Published:2023-09-01
  • Contact: Yi. Li E-mail:736828070@qq.com;liyi1012@163.com

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Abstract:

Head and neck squamous cell carcinoma is the most common malignancy of the head and neck. Neck lymph node metastasis is a significant prognostic factor, and accurate detection of neck lymph node metastasis plays a major role in surgical and adjuvant treatment planning for head and neck squamous cell carcinoma. Sentinel lymph nodes can accurately detect and assess neck metastases and unpredictable lymphatic drainage patterns. Currently, the blue dye method is still predominantly used in clinical practice. In recent years, with the development of near-infrared fluorescence technology and other techniques, many studies have focused on the accuracy of the new technique and the combined application of multiple techniques for the assessment of anterior lymph node metastasis. In this article, we will review the detection and progress of sentinel lymph nodes in head and neck squamous cell carcinoma, aiming to provide ideas for new methods of clinical detection.

Key words: sentinel lymph node, head and neck squamous carcinoma, diagnosis

CLC Number: 

  • R 782

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1 Johnson DE, Burtness B, Leemans CR, et al. Author correction: head and neck squamous cell carcinoma[J]. Nat Rev Dis Primers, 2023, 9(1): 4.
2 Ferlay J, Colombet M, Soerjomataram I, et al. Estimating the global cancer incidence and mortality in 2018: GLOBOCAN sources and methods[J]. Int J Cancer, 2019, 144(8): 1941-1953.
3 Bray F, Ferlay J, Soerjomataram I, et al. Global cancer statistics 2018: GLOBOCAN estimates of incidence and mortality worldwide for 36 cancers in 185 countries[J]. CA Cancer J Clin, 2018, 68(6): 394-424.
4 Ferlito A, Rinaldo A, Robbins KT, et al. Changing concepts in the surgical management of the cervical node metastasis[J]. Oral Oncol, 2003, 39(5): 429-435.
5 Sharma D, Koshy G, Grover S, et al. Sentinel Lymph node biopsy: a new approach in the management of head and neck cancers[J]. Sultan Qaboos Univ Med J, 2017, 17(1): e3-e10.
6 Chikamatsu K, Kamada H, Ninomiya H, et al. A preliminary study on sentinel lymph node biopsy: feasibility and predictive ability in oral cavity cancer[J]. Ann Nucl Med, 2004, 18(3): 257-262.
7 Hanai N, Asakage T, Kiyota N, et al. Controversies in relation to neck management in N0 early oral tongue cancer[J]. Jpn J Clin Oncol, 2019, 49(4): 297-305.
8 Ho CM, Lam KH, Wei WI, et al. Occult lymph node metastasis in small oral tongue cancers[J]. Head Neck, 1992, 14(5): 359-363.
9 van den Brekel MW, Stel HV, Castelijns JA, et al. Cervical lymph node metastasis: assessment of radiologic criteria[J]. Radiology, 1990, 177(2): 379-384.
10 Suzuki S, Honda K, Nanjo H, et al. CD147 expression correlates with lymph node metastasis in T1-T2 squamous cell carcinoma of the tongue[J]. Oncol Lett, 2017, 14(4): 4670-4676.
11 Spector JG, Sessions DG, Haughey BH, et al. Delayed regional metastases, distant metastases, and second primary malignancies in squamous cell carcinomas of the larynx and hypopharynx[J]. Laryngoscope, 2001, 111(6): 1079-1087.
12 Calabrese L, Bruschini R, Ansarin M, et al. Role of sentinel lymph node biopsy in oral cancer[J]. Acta Otorhinolaryngol Ital, 2006, 26(6): 345-349.
13 Civantos FJ, Zitsch RP, Schuller DE, et al. Sentinel lymph node biopsy accurately stages the regional lymph nodes for T1-T2 oral squamous cell carcinomas: results of a prospective multi-institutional trial[J]. J Clin Oncol, 2010, 28(8): 1395-1400.
14 Alvarez Amézaga J, Barbier Herrero L, Pijoan del Barrio JI, et al. Diagnostic efficacy of sentinel node biopsy in oral squamous cell carcinoma. Cohort study and meta-analysis[J]. Med Oral Patol Oral Cir Bucal, 2007, 12(3): E235-E243.
15 Stefanicka P, Profant M, Duchaj B, et al. Sentinel lymph node radiolocalization and biopsy in oral ca-vity and oropharynx mucosal squamous cell carcinoma[J]. Bratisl Lek Listy, 2010, 111(11): 590-594.
16 den Toom IJ, Boeve K, Lobeek D, et al. Elective neck dissection or sentinel lymph node biopsy in early stage oral cavity cancer patients: the Dutch experience[J]. Cancers (Basel), 2020, 12(7): 1783.
17 de Bree R, Dankbaar JW, de Keizer B. New deve-lopments in sentinel lymph node biopsy procedure in localized oral cancer[J]. JAMA Otolaryngol Head Neck Surg, 2019, 145(8): 741-742.
18 Varghese P, Abdel-Rahman AT, Akberali S, et al. Methylene blue dye: a safe and effective alternative for sentinel lymph node localization[J]. Breast J, 2008, 14(1): 61-67.
19 Sangwan P, Nilakantan A, Patnaik U, et al. Sentinel lymph node localization using 1% isosulfan blue dye in cases of early oral cavity and oropharyngeal squamous cell carcinoma[J]. Indian J Otolaryngol Head Neck Surg, 2015, 67(): 56-61.
20 Vishnoi JR, Kumar V, Gupta S, et al. Outcome of sentinel lymph node biopsy in early-stage squamous cell carcinoma of the oral cavity with methylene blue dye alone: a prospective validation study[J]. Br J Oral Maxillofac Surg, 2019, 57(8): 755-759.
21 Niebling MG, Pleijhuis RG, Bastiaannet E, et al. A systematic review and meta-analyses of sentinel lymph node identification in breast cancer and melanoma, a plea for tracer mapping[J]. Eur J Surg Oncol, 2016, 42(4): 466-473.
22 Subramanian S, Dandekar P, Jain R, et al. Technetium-99m-labeled poly(DL-lactide-co-glycolide) na-noparticles as an alternative for sentinel lymph node imaging[J]. Cancer Biother Radiopharm, 2010, 25(6): 637-644.
23 Jung SY, Kim SK, Kim SW, et al. Comparison of sentinel lymph node biopsy guided by the multimo-dal method of indocyanine green fluorescence, radioisotope, and blue dye versus the radioisotope me-thod in breast cancer: a randomized controlled trial[J]. Ann Surg Oncol, 2014, 21(4): 1254-1259.
24 Wilhelm AJ, Mijnhout GS, Franssen EJ. Radiopharmaceuticals in sentinel lymph-node detection-an overview[J]. Eur J Nucl Med, 1999, 26(4 ): S36-S42.
25 Brouwer OR, van den Berg NS, Mathéron HM, et al. A hybrid radioactive and fluorescent tracer for sentinel node biopsy in penile carcinoma as a potential replacement for blue dye[J]. Eur Urol, 2014, 65(3): 600-609.
26 Yamauchi K, Nagafuji H, Nakamura T, et al. Feasibility of ICG fluorescence-guided sentinel node biopsy in animal models using the HyperEye medical system[J]. Ann Surg Oncol, 2011, 18(7): 2042-2047.
27 Schaafsma BE, Mieog JS, Hutteman M, et al. The clinical use of indocyanine green as a near-infrared fluorescent contrast agent for image-guided oncologic surgery[J]. J Surg Oncol, 2011, 104(3): 323-332.
28 Fujisawa Y, Nakamura Y, Kawachi Y, et al. Indocyanine green fluorescence-navigated sentinel node biopsy showed higher sensitivity than the radioisotope or blue dye method, which may help to reduce false-negative cases in skin cancer[J]. J Surg Oncol, 2012, 106(1): 41-45.
29 Bredell MG. Sentinel lymph node mapping by indocyanin green fluorescence imaging in oropharyngeal cancer-preliminary experience[J]. Head Neck Oncol, 2010, 2: 31.
30 Al-Dam A, Precht C, Barbe A, et al. Sensitivity and specificity of sentinel lymph node biopsy in patients with oral squamous cell carcinomas using indocyanine green fluorescence imaging[J]. J Craniomaxillofac Surg, 2018, 46(8): 1379-1384.
31 van der Vorst JR, Schaafsma BE, Verbeek FP, et al. Near-infrared fluorescence sentinel lymph node mapping of the oral cavity in head and neck cancer patients[J]. Oral Oncol, 2013, 49(1): 15-19.
32 Nakamura T, Kogashiwa Y, Nagafuji H, et al. Validity of sentinel lymph node biopsy by ICG fluorescence for early head and neck cancer[J]. Anticancer Res, 2015, 35(3): 1669-1674.
33 Kågedal Å, Margolin G, Held C, et al. A novel sentinel lymph node approach in oral squamous cell carcinoma[J]. Curr Pharm Des, 2020, 26(31): 3834-3839.
34 Kim JH, Byeon HK, Kim DH, et al. ICG-guided sentinel lymph node sampling during robotic retroauricular neck dissection in cN0 oral cancer[J]. Otolaryngol Head Neck Surg, 2020, 162(3): 410-413.
35 Araki K, Mizokami D, Tomifuji M, et al. Novel indocyanine green-phytate colloid technique for sentinel node detection in head and neck: mouse study[J]. Otolaryngol Head Neck Surg, 2014, 151(2): 279-285.
36 Kogashiwa Y, Sakurai H, Akimoto Y, et al. Sentinel node biopsy for the head and neck using contrast-enhanced ultrasonography combined with indocyanine green fluorescence in animal models: a feasibility study[J]. PLoS One, 2015, 10(7): e0132511.
37 van Leeuwen AC, Buckle T, Bendle G, et al. Tracer-cocktail injections for combined pre-and intraoperative multimodal imaging of lymph nodes in a spontaneous mouse prostate tumor model[J]. J Biomed Opt, 2011, 16(1): 016004.
38 Cousins A, Thompson SK, Wedding AB, et al. Clinical relevance of novel imaging technologies for sentinel lymph node identification and staging[J]. Biotechnol Adv, 2014, 32(2): 269-279.
39 Caravan P. Strategies for increasing the sensitivity of gadolinium based MRI contrast agents[J]. Chem Soc Rev, 2006, 35(6): 512-523.
40 Mekuria SL, Debele TA, Tsai HC. Encapsulation of gadolinium oxide nanoparticle (Gd2O3) contrasting agents in PAMAM dendrimer templates for enhanced magnetic resonance imaging in vivo [J]. ACS Appl Mater Interfaces, 2017, 9(8): 6782-6795.
41 Partridge SC, Kurland BF, Liu CL, et al. Tumor-induced lymph node alterations detected by MRI lymphography using gadolinium nanoparticles[J]. Sci Rep, 2015, 5: 15641.
42 Loo BW Jr, Draney MT, Sivanandan R, et al. Indirect MR lymphangiography of the head and neck u-sing conventional gadolinium contrast: a pilot study in humans[J]. Int J Radiat Oncol Biol Phys, 2006, 66(2): 462-468.
43 Bae S, Lee HJ, Nam W, et al. MR lymphography for sentinel lymph node detection in patients with oral cavity cancer: preliminary clinical study[J]. Head Neck, 2018, 40(7): 1483-1488.
44 Choi SH, Moon WK. Contrast-enhanced MR ima-ging of lymph nodes in cancer patients[J]. Korean J Radiol, 2010, 11(4): 383-394.
45 Lu BL, Wang H, Lu Q, et al. Novel hybrid dextran-gadolinium nanoparticles as high-relaxivity T1 magnetic resonance imaging contrast agent for mapping the sentinel lymph node[J]. J Comput Assist Tomogr, 2019, 43(2): 350-357.
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