Int J Stomatol

Inter J Stomatol ›› 2018, Vol. 45 ›› Issue (6): 710-715.doi: 10.7518/gjkq.2018.06.015

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Progress of salivaomics in diagnosis of oral cancer

Qian Li,Ping Zhang,Jiao Chen,Xin Zeng,Yun Feng()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & West China School of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2017-12-29 Revised:2018-04-17 Online:2018-11-01 Published:2018-11-15
  • Contact: Yun Feng E-mail:953463551@qq.com
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81372892);Sichuan Province Science and Technology Innovation Team Program(JCPT2011-9)

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Abstract:

Saliva analysis has long been considered a potential alternative to blood serum and urine analyses. This body fluid is gaining popularity due to its ease of collection, safety in handling, low cost and high efficiency. Salivaomics includes six diagnostic alphabets: salivary genomics, transcriptomics, proteomics, metabolomics, microbiomics and microRNA (miRNA). Saliva contains extensive biological information, thereby playing important role in the early diagnosis of oral disorder and several systemic diseases. Direct contact between saliva and oral cancer lesions makes measurement of tumour markers in saliva an attractive alternative to serum testing. Salivaomics may offer a robust alternative for clinicians in making clinical decision in the future. This article provides an updated review on the progress of salivaomics in oral cancer diagnosis.

Key words: saliva, salivaomics, oral cancer, diagnosis

CLC Number: 

  • R333.1

TrendMD: 
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