Int J Stomatol

Int J Stomatol ›› 2022, Vol. 49 ›› Issue (5): 556-560.doi: 10.7518/gjkq.2022093

• Reviews • Previous Articles     Next Articles

Role of autophagy in salivary glands of Sjögren’s syndrome

Ye Yulin(),Jiang Liting,Gao Yiming.()   

  1. Dept. of Stomatology, Ruijin Hospital, Shanghai Jiao Tong University School of Medicine, College of Stomatology, Shanghai Jiao Tong University, Shanghai 200025, China
  • Received:2022-01-14 Revised:2022-06-23 Online:2022-09-01 Published:2022-09-16
  • Contact: Yiming. Gao E-mail:792121694@qq.com;drgaoym@163.com
  • Supported by:
    National Natural Science Foundation of China(81900975)

RichHTML

26

PDF (PC)

166

Abstract:

Primary Sjögren ’s syndrome is an autoimmune disease characterized by the destruction of exocrine glands, causing dry mouth, dry eyes, and multiple systemic manifestations. Autophagy is involved in the innate and adaptive immune responses. Autophagy dysregulation may break the immune homeostasis and participate in the incidence and deve-lopment of pSS. Here, we reviewed the relationship between autophagy and pSS from four aspects: the role of autophagy in the homeostasis and stress responses of salivary glands, the abnormal expression of autophagy-related proteins (ATG) in the pSS glands, the autophagy in innate immunity and adaptive immunity in pSS, and drug therapy aiming at autophagy of pSS. We provided new directions and ideas for further study on the mechanism of autophagy in pSS and ultimately contribute to prevention and treatment of pSS.

Key words: autophagy, Sjögren ’ s syndrome, salivary gland, immunity

CLC Number: 

  • R 392

TrendMD: 
1 Mizushima N, Levine B. Autophagy in human di-seases[J]. N Engl J Med, 2020, 383(16): 1564-1576.
2 Wu DJ, Adamopoulos IE. Autophagy and autoimmunity[J]. Clin Immunol Orlando Fla, 2017, 176: 55-62.
3 Brito-Zerón P, Baldini C, Bootsma H, et al. Sjögren syndrome[J]. Nat Rev Dis Primers, 2016, 2: 16047.
4 Mavragani CP, Moutsopoulos HM. Sjögren ’ s synd-rome[J]. Annu Rev Pathol, 2014, 9: 273-285.
5 Morgan-Bathke M, Lin HH, Chibly AM, et al. Deletion of ATG5 shows a role of autophagy in salivary homeostatic control[J]. J Dent Res, 2013, 92(10): 911-917.
6 Morgan-Bathke M, Lin HH, Ann DK, et al. The role of autophagy in salivary gland homeostasis and s-tress responses[J]. J Dent Res, 2015, 94(8): 1035-1040.
7 Morgan-Bathke M, Hill GA, Harris ZI, et al. Autophagy correlates with maintenance of salivary g-land function following radiation[J]. Sci Rep, 2014, 4: 5206.
8 Lin HH, Lin SM, Chung Y, et al. Dynamic involvement of ATG5 in cellular stress responses[J]. Cell Death Dis, 2014, 5: e1478.
9 Alessandri C, Ciccia F, Priori R, et al. CD4 T lymphocyte autophagy is upregulated in the salivary glands of primary Sjögren’s syndrome patients and correlates with focus score and disease activity[J]. Arthritis Res Ther, 2017, 19(1): 178.
10 Colafrancesco S, Vomero M, Iannizzotto V, et al. Autophagy occurs in lymphocytes infiltrating Sjö‑ gren’s syndrome minor salivary glands and correlates with histological severity of salivary gland lesions[J]. Arthritis Res Ther, 2020, 22(1): 238.
11 侯佳奇, 吴香香, 潘云翠, 等. IFN-γ, caspase-3, LC3-Ⅱ在原发性干燥综合征唇腺中的表达及其相关性[J]. 临床与病理杂志, 2019, 39(4): 769-775.
Hou JQ, Wu XX, Pan YC, et al. Expression and correlation of IFN-γ, caspase-3, LC3-Ⅱ in labial glands of primary Sjögren ’ s syndrome[J]. J Clin Pathol Res, 2019, 39(4): 769-775.
12 Du ZH, Ding C, Zhang Q, et al. Stem cells  from exfoliated deciduous teeth alleviate hyposalivation cau-sed by Sjögren syndrome[J]. Oral Dis, 2019, 25(6): 1530-1544.
13 Byun YS, Lee HJ, Shin S, et al. Elevation of auto-phagy markers in Sjögren syndrome dry eye[J]. Sci Rep, 2017, 7(1): 17280.
14 Lee HJ, Shin S, Yoon SG, et al. The effect of chloroquine on the development of dry eye in Sjögren syndrome animal model[J]. Invest Ophthalmol Vis Sci, 2019, 60(12): 3708-3716.
15 Barrera MJ, Aguilera S, Castro I, et al. Tofacitinib counteracts IL-6 overexpression induced by deficient autophagy: implications in Sjögren’s syndrome[J]. Rheumatol Oxf Engl, 2021, 60(4): 1951-1962.
16 Li BH, Wang FJ, Schall N, et al. Rescue of autophagy and lysosome defects in salivary glands of MRL/lpr mice by a therapeutic phosphopeptide[J]. J Autoimmun, 2018, 90: 132-145.
17 Voynova E, Lefebvre F, Qadri A, et al. Correction of autophagy impairment inhibits pathology in the NOD.H-2h4 mouse model of primary Sjögren’s syndrome[J]. J Autoimmun, 2020, 108: 102418.
18 Nakatogawa H. Mechanisms governing autophagosome biogenesis[J]. Nat Rev Mol Cell Biol, 2020, 21(8): 439-458.
19 Shintani T, Klionsky DJ. Autophagy in health and disease: a double-edged sword[J]. Science, 2004, 306(5698): 990-995.
20 Klionsky DJ, Abdel-Aziz AK, Abdelfatah S, et al. Guidelines for the use and interpretation of assays for monitoring autophagy (4th edition)[J]. Autophagy, 2021, 17(1): 1-382.
21 Deretic V, Jiang SY, Dupont N. Autophagy intersections with conventional and unconventional secretion in tissue development, remodeling and inflammation[J]. Trends Cell Biol, 2012, 22(8): 397-406.
22 New J, Thomas SM. Autophagy-dependent secretion: mechanism, factors secreted, and disease implications[J]. Autophagy, 2019, 15(10): 1682-1693.
23 Yin H, Wu HJ, Chen YJ, et al. The therapeutic and pathogenic role of autophagy in autoimmune disea-ses[J]. Front Immunol, 2018, 9: 1512.
24 Seror R, Ravaud P, Bowman SJ, et al. EULAR Sjogren’s syndrome disease activity index: development of a consensus systemic disease activity index for primary Sjogren’s syndrome[J]. Ann Rheum Dis, 2010, 69(6): 1103-1109.
25 Vitali C, Palombi G, Baldini C, et al. Sjögren’s syndrome disease damage index and disease activity index: scoring systems for the assessment of disease damage and disease activity in Sjögren’s syndrome, derived from an analysis of a cohort of Italian patients[J]. Arthritis Rheum, 2007, 56(7): 2223-2231.
26 Katsiougiannis S, Tenta R, Skopouli FN. Endoplasmic reticulum stress causes autophagy and apoptosis leading to cellular redistribution of the autoantigens Ro/Sjögren’s syndrome-related antigen A (SSA) and La/SSB in salivary gland epithelial cells[J]. Clin Exp Immunol, 2015, 181(2): 244-252.
27 Byun YS, Lee HJ, Shin S, et al. Tear ATG5 as a potential novel biomarker in the diagnosis of Sjögren syndrome[J]. Diagnostics (Basel), 2021, 11(1): 71.
28 Rizzo C, Grasso G, Destro Castaniti GM, et al. Primary Sjögren syndrome: focus on innate immune cells and inflammation[J]. Vaccines (Basel), 2020, 8(2): 272.
29 Christodoulou MI, Kapsogeorgou EK, Moutsopoulos HM. Characteristics of the minor salivary gland infiltrates in Sjögren’s syndrome[J]. J Autoimmun, 2010, 34(4): 400-407.
30 Wu MY, Lu JH. Autophagy and macrophage functions: inflammatory response and phagocytosis[J]. Cells, 2019, 9(1): 70.
31 Ozaki Y, Ito T, Son Y, et al. Decrease of blood dendritic cells and increase of tissue-infiltrating dendri-tic cells are involved in the induction of Sjögren’s syndrome but not in the maintenance[J]. Clin Exp Immunol, 2010, 159(3): 315-326.
32 Lee HK, Mattei LM, Steinberg BE, et al. In vivo requirement for Atg5 in antigen presentation by dendritic cells[J]. Immunity, 2010, 32(2): 227-239.
33 Ge Y, Huang M, Yao YM. Autophagy and proinflammatory cytokines: interactions and clinical implications[J]. Cytokine Growth Factor Rev, 2018, 43: 38-46.
34 Metur SP, Klionsky DJ. Adaptive immunity at the crossroads of autophagy and metabolism[J]. Cell Mol Immunol, 2021, 18(5): 1096-1105.
35 Nirk EL, Reggiori F, Mauthe M. Hydroxychloroquine in rheumatic autoimmune disorders and beyond[J]. EMBO Mol Med, 2020, 12(8): e12476.
36 Fu L, Wu W, Sun X, et al. Glucocorticoids enhanced osteoclast autophagy through the PI3K/Akt/mTOR signaling pathway[J]. Calcif Tissue Int, 2020, 107(1): 60-71.
[1] Zhao Lingfan, Zhou Yang, Ye Xinxin, Zhang Qiang.. Poorly differentiated mucoepidermoid carcinoma of the parotid gland after renal transplantation: a case report [J]. Int J Stomatol, 2023, 50(4): 419-422.
[2] Yang Xiaoyu,Yuan Quan.. Research progress on the role of extravascular fibrinogen deposition in mucosal diseases [J]. Int J Stomatol, 2023, 50(4): 457-462.
[3] Li Guiping,Qin Xu,Zhu Guangxun.. Research progress on adenosine monophosphate-activated protein kinase in periodontal disease [J]. Int J Stomatol, 2022, 49(3): 343-348.
[4] Fang Lingli,Tan Xi,Ye Yusi,Huang Lan,He Yao. Experimental study on behavior changes of condylar chondrocytes in early stage of temporomandibular joint degeneration [J]. Int J Stomatol, 2021, 48(4): 417-425.
[5] Zhou Feng,Chen Ye,Chen Chen,Zhang Yining,Geng Ruiman,Liu Ji. Mechanism of sirtuin 1 in regulating periodontitis [J]. Int J Stomatol, 2021, 48(3): 341-346.
[6] Yin Yuanyuan,Ma Huayu,Li Xinyi,Xu Jingchen,Liu Ting,Chen Song,He Shushu. Expression of autophagy related genes in mice periodontal tissue during orthodontic tooth movement [J]. Int J Stomatol, 2020, 47(6): 627-634.
[7] Zhu Junjin,Zhou Jiaqi,Wu Yingying. Function of autophagy induced by mammalian target of rapamycin complex 1 in bone metabolism [J]. Int J Stomatol, 2020, 47(1): 84-89.
[8] Chen Dong,Yang Zheng,Jiang Li. Research progress on the evaluation and management of radiation-induced xerostomia [J]. Int J Stomatol, 2019, 46(6): 711-717.
[9] Wei Li,Xiaolin. Nong. Effect and mechanism of diabetes on saliva secretion and salivary glands [J]. Inter J Stomatol, 2018, 45(5): 579-583.
[10] Zhang Peng, Ding Yi, Wang Qi. Research on the role of inflammaging in diabetes mellitus-associated periodontitis [J]. Inter J Stomatol, 2017, 44(6): 664-668.
[11] Li Lin, Wang Dan, Zhao Manzhu, Tang Ming. Research progress on the correlation between chronic periodontitis and neurodegenerative diseases [J]. Inter J Stomatol, 2017, 44(5): 514-518.
[12] Chen Guanhui, Hou Jinsong. Hypoxia and autophagy and their correlation with tumorigenesis and development [J]. Inter J Stomatol, 2016, 43(5): 584-588.
[13] Ren Jingyi1, Liu Xinchan1, Ding Ye1, Yu Hongqiang1, Zhou Yanmin1, Yu Weixian2. Interaction of autophagy and inflammation in periodontitis [J]. Inter J Stomatol, 2016, 43(4): 462-467.
[14] Sun Han, Hou Xu, Yu Wenwen, Qi Jia, Liu Jiming, Lou Yixin, Sun Xinhua.. Advancement of the role of Toll-like receptors in bone reconstruction [J]. Inter J Stomatol, 2015, 42(4): 450-452.
[15] Wang Xiaxia, Sun Hongying. Hypoxia-inducible factor-1α and oral lichen planus [J]. Inter J Stomatol, 2015, 42(3): 318-322.
Viewed
Full text


Abstract

Cited
  Shared   
  Discussed   
[1] . [J]. Foreign Med Sci: Stomatol, 1999, 26(06): .
[2] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[3] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[4] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[5] . [J]. Foreign Med Sci: Stomatol, 1999, 26(05): .
[6] . [J]. Foreign Med Sci: Stomatol, 1999, 26(04): .
[7] . [J]. Foreign Med Sci: Stomatol, 2005, 32(06): 458 -460 .
[8] . [J]. Foreign Med Sci: Stomatol, 2005, 32(06): 452 -454 .
[9] . [J]. Inter J Stomatol, 2008, 35(S1): .
[10] . [J]. Inter J Stomatol, 2008, 35(S1): .