Int J Stomatol

Inter J Stomatol ›› 2018, Vol. 45 ›› Issue (5): 579-583.doi: 10.7518/gjkq.2018.05.014

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Effect and mechanism of diabetes on saliva secretion and salivary glands

Wei Li,Xiaolin. Nong()   

  1. Dept. of Oral and Maxillofacial Surgery, College and Hospital of Stomatology, Guangxi Medical University, Nanning 530021, China
  • Received:2017-10-22 Revised:2018-04-30 Online:2018-09-01 Published:2018-09-20
  • Contact: Xiaolin. Nong E-mail:xnong@gxmu.edu.cn
  • Supported by:
    This study was supported by Scientific Research and Technology Development Project of Guangxi(桂科能14123006-2);Guangxi medical and health appropriate technology development and popularization and application project(S201688);Guangxi higher education undergraduate teaching reform project(2016JGA161-2);Innovation Project of Guangxi Graduate Education(201010598RY10)

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Abstract:

Diabetes and its complications can greatly reduce the quality of life of patients, dry mouth and more water intake is one of the main symptoms of diabetes. Saliva decrements and salivary glands changes may be important causes of diabetic patients to drink more, but also one of the risk factors for other oral problems. Studying the effection mechanism of diabetes on salivary secretion and salivary glands will be important for preventing and curing patients’ symptoms of thirst, maintaining oral health and improving their quality of life. This article reviews the effect of diabetes on saliva secretion and salivary glands and its mechanism.

Key words: diabetes, salivary glands, saliva, saliva reduction, dry mouth

CLC Number: 

  • R780.1

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[1] International Diabetes Federation. IDF diabetes atlas-7th Edition[EB/OL]. ,[ 2015-12-01].
[2] Löe H , Periodontal disease. The sixth complication of diabetes mellitus[J]. Diabetes Care, 1993,16(1):329-334.
doi: 10.2337/diacare.16.1.329 pmid: 8422804
[3] Negrato CA, Tarzia O , Buccal alterations in diabetes mellitus[J]. Diabetol Metab Syndr, 2010,2:3.
doi: 10.1186/1758-5996-2-3 pmid: 20180965
[4] Takeuchi K, Furuta M, Takeshita T , et al. Risk factors for reduced salivary flow rate in a Japanese popula-tion: the Hisayama Study[J]. Biomed Res Int, 2015,2015:381821.
doi: 10.1155/2015/381821 pmid: 4332456
[5] Pedersen AM, Bardow A, Jensen SB , et al. Saliva and gastrointestinal functions of taste, mastication, swallowing and digestion[J]. Oral Dis, 2002,8(3):117-129.
doi: 10.1034/j.1601-0825.2002.02851.x pmid: 12108756
[6] López-Pintor RM, Casañas E, González-Serrano J , et al. Xerostomia, hyposalivation, and salivary flow in diabetes patients[J]. J Diabetes Res, 2016,2016:4372852.
doi: 10.1155/2016/4372852
[7] Lima DLF, Carneiro SDRM, Barbosa FTS , et al. Salivary flow and xerostomia in older patients with type 2 diabetes mellitus[J]. PLoS One, 2017,12(8):e0180891.
doi: 10.1371/journal.pone.0180891 pmid: 5540406
[8] Kamata M, Shirakawa M, Kikuchi K , et al. Histo-logical analysis of the sublingual gland in rats with streptozotocin-induced diabetes[J]. Okajimas Folia Anat Jpn, 2007,84(2):71-76.
doi: 10.2535/ofaj.84.71 pmid: 17969996
[9] 李维善, 孙庆顺 . 实验性糖尿病大鼠颌下腺超微结构观察[J]. 临床口腔医学杂志, 2006,22(3):147-149.
doi: 10.3969/j.issn.1003-1634.2006.03.007
Li WS, Sun QS . The ultrastructure study on the submandibular glands in experimental diabetes rats[J]. J Clin Stomatol, 2006,22(3):147-149.
doi: 10.3969/j.issn.1003-1634.2006.03.007
[10] Agre P , Aquaporin water channels (Nobel Lecture)[J]. Angew Chem Int Ed Engl, 2004,43(33):4278-4290.
doi: 10.1002/chin.200445287
[11] Verkman AS , Novel roles of aquaporins revealed by phenotype analysis of knockout mice[J]. Rev Physiol Biochem Pharmacol, 2005,155:31-55.
doi: 10.1007/3-540-28217-3
[12] Delporte C , Aquaporins in salivary glands and pan-creas[J]. Biochim Biophys Acta, 2014,1840(5):1524-1532.
doi: 10.1016/j.bbagen.2013.08.007 pmid: 23954206
[13] Ishikawa Y, Cho G, Yuan Z , et al. Aquaporin-5 water channel in lipid rafts of rat parotid glands[J]. Biochim Biophys Acta, 2006,1758(8):1053-1060.
doi: 10.1016/j.bbamem.2006.03.026 pmid: 16712780
[14] Ishikawa Y, Inoue N, Zhenfang Y , et al. Molecular mechanisms and drug development in aquaporin wa- ter channel diseases: the translocation of aquaporin-5 from lipid rafts to the apical plasma membranes of parotid glands of normal rats and the impairment of it in diabetic or aged rats[J]. J Pharmacol Sci, 2004,96(3):271-275.
doi: 10.1254/jphs.FMJ04004X6
[15] Bhattarai KR, Lee SW, Kim SH , et al. Ixeris dentata extract regulates salivary secretion through the acti-vation of aquaporin-5 and prevents diabetes-induced xerostomia[J]. J Exp Pharmacol, 2017,9:81-91.
doi: 10.2147/JEP
[16] Mednieks MI, Szczepanski A, Clark B , et al. Protein expression in salivary glands of rats with streptozo-tocin diabetes[J]. Int J Exp Pathol, 2009,90(4):412-422.
doi: 10.1111/j.1365-2613.2009.00662.x pmid: 19659899
[17] 王云飞, 钱品品, 王勇帅 , 等. 唾液淀粉酶活性与肥胖关系初探[J]. 山东师范大学学报(自然科学版), 2017,32(2):121-124.
doi: 10.3969/j.issn.1001-4748.2017.02.020
Wang YF, Qian PP, Wang YS , et al. The preliminary study on the relationship between salivary alpha-amylase activity and obesity[J]. J Shandong Normal Univers (Nat Sci), 2017,32(2):121-124.
doi: 10.3969/j.issn.1001-4748.2017.02.020
[18] Kaufman E, Lamster IB , Analysis of saliva for perio-dontal diagnosis—a review[J]. J Clin Periodontol, 2000,27(7):453-465.
doi: 10.1034/j.1600-051x.2000.027007453.x pmid: 10914885
[19] Numabe Y, Hisano A, Kamoi K , et al. Analysis of saliva for periodontal diagnosis and monitoring[J]. Dent Japan, 2004,40:115-119.
[20] Defagó MD, Valentich MA, Actis AB , Lipid charac-terization of human saliva[J]. J Calif Dent Assoc, 2011,39(12):874-880.
[21] Kensche A, Reich M, Kümmerer K , et al. Lipids in preventive dentistry[J]. Clin Oral Investig, 2013,17(3):669-685.
doi: 10.1007/s00784-012-0835-9
[22] Hand AR, Weiss RE , Effects of streptozotocin-induced diabetes on the rat parotid gland[J]. Lab Invest, 1984,51(4):429-440.
doi: 10.1016/S0015-7368(84)72350-4 pmid: 6482385
[23] Łukaszuk B, Kurek K, Mikłosz A , et al. The role of PGC-1α in the development of insulin resistance in skeletal muscle-revisited[J]. Cell Physiol Biochem, 2015,37(6):2288-2296.
doi: 10.1159/000438584
[24] Bonen A, Tandon NN, Glatz JF , et al. The fatty acid transporter FAT/CD36 is upregulated in subcuta-neous and visceral adipose tissues in human obesity and type 2 diabetes[J]. Int J Obes (Lond), 2006,30(6):877-883.
doi: 10.1038/sj.ijo.0803212
[25] Matczuk J, Zalewska A, Łukaszuk B , et al. Insulin resistance and obesity affect lipid profile in the salivary glands[J]. J Diabetes Res, 2016,2016:8163474.
doi: 10.1155/2016/8163474
[26] Matczuk J, Zalewska A, Łukaszuk B , et al. Effect of streptozotocin-induced diabetes on lipids metabolism in the salivary glands[J]. Prostaglandins Other Lipid Mediat, 2016,126:9-15.
doi: 10.1016/j.prostaglandins.2016.08.003 pmid: 27640168
[27] Garbowska M, Łukaszuk B, Mikłosz A , et al. Sphin-golipids metabolism in the salivary glands of rats with obesity and streptozotocin induced diabetes[J]. J Cell Physiol, 2017,232(10):2766-2775.
doi: 10.1002/jcp.v232.10
[28] Katona K, Elekes E, Farkas N , et al. Image analysis of fatty infiltration in labial salivary gland biopsies: extent and its correlation to age, obesity and diabetes[J]. J Oral Pathol Med, 2017,46(7):537-542.
doi: 10.1111/jop.2017.46.issue-7
[29] Nogueira FN, Carvalho AM, Yamaguti PM , et al. Antioxidant parameters and lipid peroxidation in salivary glands of streptozotocin-induced diabetic rats[J]. Clin Chim Acta, 2005,353(1/2):133-139.
doi: 10.1016/j.cccn.2004.11.004
[30] Deconte SR, Oliveira RJ, Calábria LK , et al. Altera-tions of antioxidant biomarkers and type Ⅰ collagen deposition in the parotid gland of streptozotocin-in-duced diabetic rats[J]. Arch Oral Biol, 2011,56(8):744-751.
doi: 10.1016/j.archoralbio.2011.01.005
[31] Zalewska A, Knaś M, Maciejczyk M , et al. Antioxi-dant profile, carbonyl and lipid oxidation markers in the parotid and submandibular glands of rats in different periods of streptozotocin induced diabetes[J]. Arch Oral Biol, 2015,60(9):1375-1386.
doi: 10.1016/j.archoralbio.2015.06.012
[32] Knaś M, Maciejczyk M, Daniszewska I , et al. Oxida-tive damage to the salivary glands of rats with strep-tozotocin-induced diabetes-temporal study: oxidative stress and diabetic salivary glands[J]. J Diabetes Res, 2016,2016:4583742.
[33] Aljerf L, Alhaffar I , Salivary distinctiveness and modifications in males with diabetes and Behçet’s disease[J]. Biochem Res Int, 2017,2017:9596202.
doi: 10.1155/2017/9596202 pmid: 1
[34] Aitken JP, Ortiz C, Morales-Bozo I , et al. α-2-macro-globulin in saliva is associated with glycemic control in patients with type 2 diabetes mellitus[J]. Dis Markers, 2015,2015:128653.
[35] Satish BN, Srikala P, Maharudrappa B , et al. Saliva: a tool in assessing glucose levels in diabetes mellitus[J]. J Int Oral Health, 2014,6(2):114-117.
pmid: 24876711
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