Int J Stomatol ›› 2020, Vol. 47 ›› Issue (5): 522-529.doi: 10.7518/gjkq.2020095

• Oral Microecology • Previous Articles     Next Articles

Bacterial diversity of oral flora in patients with diabetes

Yi Zumu1(),Wang Xinyu1,Wu Yingying2()   

  1. 1.State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & West China School of Stomatology, Sichuan University, Chengdu 610041, China
    2.State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Oral Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2020-01-05 Revised:2020-05-02 Online:2020-09-01 Published:2020-09-16
  • Contact: Yingying Wu;
  • Supported by:
    National Natural Science Foundation of China(81970966);NResearch Fund for Sichuan University Excellent Young Scholars(2017SCU04A21)


The ecological imbalance of oral flora is closely related to oral and systemic diseases. Studies have found a close two-way relationship between periodontal disease and diabetes. The starting factor of periodontal disease is bacteria. Diabetes is one of the main risk factors for periodontal disease. Whether diabetes affects the development of periodontal disease by affecting the structure of human oral flora remains controversial. Most researchers believe that bacteria may be the key link in the interaction between diabetes and periodontal disease. The change in oral bacterial diversity in patients with diabetes may play a key role. Some believe that the oral bacterial diversity of patients with and without diabetes does not differ. This article reviews the different perspectives of the effects of diabetes on the structure of oral flora in recent years and describes possible mechanisms. The changes in glucose levels in saliva and gingival crevicular fluid, inflammation, and inflammatory factors in patients with diabetes are the main reasons for the influence of diabetes on oral bacterial diversity.

Key words: diabetes, oral disease, bacterial diversity

CLC Number: 

  • R780.2

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