Int J Stomatol

Int J Stomatol ›› 2023, Vol. 50 ›› Issue (2): 210-216.doi: 10.7518/gjkq.2023021

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Effects of flavonoids on oral microorganisms and its mechanism

Chen Yifei1(),Zhang Binjing1,Feng Shuqi1,Xu Rui1,Yang Shuxian1,Li Yuqing2()   

  1. 1.State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Di-seases & West China School of Stomatology, Sichuan University, Chengdu 610041, China
    2.State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2022-05-12 Revised:2022-09-09 Online:2023-03-01 Published:2023-03-14
  • Contact: Yuqing Li E-mail:1677935971@qq.com;liyuqing@scu.edu.cn
  • Supported by:
    National Natural Science Foundation of China(32170046);International Research and Development Program of Sichuan(2022YFH0048)

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Abstract:

Flavonoids are natural organic compounds widely existed in plants. In recent years, there has been an increasing amount of research on the effects and processes of flavonoids on oral microbes such as Streptococcus mutans, Porphyromonas gingivalis, and Candida albicans, due to their strong antibacterial activity. It demonstrates that a variety of flavonoids have an inhibitory impact on oral pathogenic bacteria and may be useful in the prevention and treatment of oral illnesses and oral health care. This review summarized the effects and mechanism of flavonoids on oral microorga-nisms and evaluated the application value of flavonoids in prevention and treatment of oral diseases and oral health care.

Key words: flavonoids, oral microorganism, antimicrobial effect, oral disease prevention

CLC Number: 

  • R 780.1

TrendMD: 
1 Wade WG. The oral microbiome in health and di-sease[J]. Pharmacol Res, 2013, 69(1): 137-143.
2 Mosaddad SA, Tahmasebi E, Yazdanian A, et al. Oral microbial biofilms: an update[J]. Eur J Clin Microbiol Infect Dis, 2019, 38(11): 2005-2019.
3 Lamont RJ, Koo H, Hajishengallis G. The oral microbiota: dynamic communities and host interactions[J]. Nat Rev Microbiol, 2018, 16(12): 745-759.
4 Zhang YH, Wang X, Li HX, et al. Human oral microbiota and its modulation for oral health[J]. Biomed Pharmacother, 2018, 99: 883-893.
5 Xie YX, Yang WJ, Tang F, et al. Antibacterial activities of flavonoids: structure-activity relationship and mechanism[J]. Curr Med Chem, 2015, 22(1): 132-149.
6 Farhadi F, Khameneh B, Iranshahi M, et al. Antibacterial activity of flavonoids and their structure-acti-vity relationship: an update review[J]. Phytother Res, 2019, 33(1): 13-40.
7 王露, 赵天祎, 蔡明. 植物腺毛中防御物质的合成与调控及转运研究进展[J]. 西北植物学报, 2021, 41(2): 338-347.
Wang L, Zhao TY, Cai M. Advances in synthesis, regulation and transportation of defensive substan-ces produced in plant glandular Trichomes[J]. Acta Bot an Boreali-Occidentalia Sin, 2021, 41(2): 338-347.
8 Kumar S, Pandey AK. Chemistry and biological activities of flavonoids: an overview[J]. Sci World J, 2013, 2013: 162750.
9 Aumeeruddy-Elalfi Z, Gurib-Fakim A, Mahomoo-dally F. Antimicrobial, antibiotic potentiating activity and phytochemical profile of essential oils from exotic and endemic medicinal plants of Mauritius[J]. Ind Crops Prod, 2015, 71: 197-204.
10 Heim KE, Tagliaferro AR, Bobilya DJ. Flavonoid antioxidants: chemistry, metabolism and structure-activity relationships[J]. J Nutr Biochem, 2002, 13(10): 572-584.
11 Kumar S, Pandey AK. Chemistry and biological activities of flavonoids: an overview[J]. Scie World J, 2013, 2013: 162750.
12 Alseekh S, Perez de Souza L, Benina M, et al. The style and substance of plant flavonoid decoration; towards defining both structure and function[J]. Phytochemistry, 2020, 174: 112347.
13 Panche AN, Diwan AD, Chandra SR. Flavonoids: an overview[J]. J Nutr Sci, 2016, 5: e47.
14 Zeng Y, Nikitkova A, Abdelsalam H, et al. Activity of quercetin and kaemferol against Streptococcus mutans biofilm[J]. Arch Oral Biol, 2019, 98: 9-16.
15 Memariani H, Memariani M, Ghasemian A. An overview on anti-biofilm properties of quercetin against bacterial pathogens[J]. World J Microbiol Biotechnol, 2019, 35(9): 143.
16 He ZY, Zhang X, Song ZC, et al. Quercetin inhibits virulence properties of Porphyromas gingivalis in periodontal disease[J]. Sci Rep, 2020, 10(1): 18313.
17 Patra JK, Kim ES, Oh K, et al. Antibacterial effect of crude extract and metabolites of Phytolacca Americana on pathogens responsible for periodontal inflammatory diseases and dental caries[J]. BMC Complement Altern Med, 2014, 14: 343.
18 Song X, Tan L, Wang M, et al. Myricetin: a review of the most recent research[J]. Biomed Pharmaco-ther, 2021, 134: 111017.
19 Hu P, Lv BB, Yang KX, et al. Discovery of myricetin as an inhibitor against Streptococcus mutans and an anti-adhesion approach to biofilm formation[J]. Int J Med Microbiol, 2021, 311(4): 151512.
20 Grenier D, Chen HQ, Ben Lagha A, et al. Dual action of myricetin on porphyromonas gingivalis and the inflammatory response of host cells: a promising therapeutic molecule for periodontal diseases[J]. PLoS One, 2015, 10(6): e0131758.
21 王海涛, 石姗姗, 李银霞, 等. 染料木素的抑菌活性及其机制的研究[J]. 营养学报, 2008, 30(4): 403-406, 409.
Wang HT, Shi SS, Li YX, et al. Study on anti-micrio-bial activity of genistein and its mechanism[J]. Acta Nutr Sin, 2008, 30(4): 403-406, 409.
22 Cui SN, Hassan RY, Heintz-Buschart A, et al. Regulation of Candida albicans interaction with macrophages through the activation of HOG pathway by genistein[J]. Molecules, 2016, 21(2): 162.
23 Messier C, Grenier D. Effect of licorice compounds licochalcone A, glabridin and glycyrrhizic acid on growth and virulence properties of Candida albicans [J]. Mycoses, 2011, 54(6): e801-e806.
24 Seleem D, Pardi V, Murata RM. Review of flavonoids: a diverse group of natural compounds with anti-Candida albicans activity in vitro [J]. Arch Oral Biol, 2017, 76: 76-83.
25 Sahu NK, Balbhadra SS, Choudhary J, et al. Explo-ring pharmacological significance of chalcone scaffold: a review[J]. Curr Med Chem, 2012, 19(2): 209-225.
26 López SN, Castelli MV, Zacchino SA, et al. In vitro antifungal evaluation and structure-activity relationships of a new series of chalcone derivatives and synthetic analogues, with inhibitory properties a-gainst polymers of the fungal cell wall[J]. Bioorg Med Chem, 2001, 9(8): 1999-2013.
27 Seleem D, Benso B, Noguti J, et al. In vitro and in vivo antifungal activity of lichochalcone-a against Candida albicans biofilms[J]. PLoS One, 2016, 11(6): e0157188.
28 Lin MY, Yuan ZL, Hu DD, et al. Effect of loureirin A against Candida albicans biofilms[J]. Chin J Nat Med, 2019, 17(8): 616-623.
29 Fan JY, Yi T, Sze-To CM, et al. A systematic review of the botanical, phytochemical and pharmacological profile of Dracaena cochinchinensis, a plant source of the ethnomedicine “dragon’s blood”[J]. Molecules, 2014, 19(7): 10650-10669.
30 He J, Giusti MM. Anthocyanins: natural colorants with health-promoting properties[J]. Annu Rev Food Sci Technol, 2010, 1: 163-187.
31 Putta S, Yarla NS, Peluso I, et al. Anthocyanins: multi-target agents for prevention and therapy of ch-ronic diseases[J]. Curr Pharm Des, 2017, 23(41): 6321-6346.
32 Tian LM, Tan YS, Chen GW, et al. Metabolism of anthocyanins and consequent effects on the gut microbiota[J]. Crit Rev Food Sci Nutr, 2019, 59(6): 982-991.
33 Hrynash H, Pilly VK, Mankovskaia A, et al. Anthocyanin incorporated dental copolymer: bacterial growth inhibition, mechanical properties, and compound release rates and stability by 1H NMR[J]. Int J Dent, 2014, 2014: 289401.
34 Mallery SR, Budendorf DE, Larsen MP, et al. Effects of human oral mucosal tissue, saliva, and oral microflora on intraoral metabolism and bioactivation of black raspberry anthocyanins[J]. Cancer Prev Res (Phila), 2011, 4(8): 1209-1221.
35 Kamonpatana K, Failla ML, Kumar PS, et al. Anthocyanin structure determines susceptibility to microbial degradation and bioavailability to the buccal mucosa[J]. J Agric Food Chem, 2014, 62(29): 6903-6910.
36 Gutiérrez-Venegas G, Gómez-Mora JA, Meraz-Rodríguez MA, et al. Effect of flavonoids on antimicrobial activity of microorganisms present in dental plaque[J]. Heliyon, 2019, 5(12): e03013.
37 Liu YC, Han L, Yang HY, et al. Effect of apigenin on surface-associated characteristics and adherence of Streptococcus mutans [J]. Dent Mater J, 2020, 39(6): 933-940.
38 André CB, Rosalen PL, Giannini M, et al. Incorporation of Apigenin and tt-Farnesol into dental composites to modulate the Streptococcus mutans virulence[J]. Dent Mater, 2021, 37(4): e201-e212.
39 Seleem D, Pardi V, Murata RM. Review of flavonoids: a diverse group of natural compounds with anti-Candida albicans activity in vitro [J]. Arch Oral Biol, 2017, 76: 76-83.
40 Zeng Y, Nikitkova A, Abdelsalam H, et al. Activity of quercetin and kaemferol against Streptococcus mutans biofilm[J]. Arch Oral Biol, 2019, 98: 9-16.
41 何春霞, 王爱英, 古丽江, 等. 黄酮类化合物的药理学作用研究进展[J]. 黑龙江农业科学, 2011(11): 131-135.
He CX, Wang AY, Gu LJ, et al. Advance progress of medicinal significance of the flavonoids[J]. Heilongjiang Agric Sci, 2011(11): 131-135.
42 Marcoux E, Lagha AB, Gauthier P, et al. Antimicrobial activities of natural plant compounds against endodontic pathogens and biocompatibility with human gingival fibroblasts[J]. Arch Oral Biol, 2020, 116: 104734.
43 Jeong MK, Cho CK, Yoo HS. General and genetic toxicology of enzyme-treated ginseng extract: toxicology of ginseng Rh2[J]. J Pharmacopuncture, 2016, 19(3): 213-224.
44 李伶俐, 李潇. 黄芩苷预防和治疗牙周炎研究进展[J]. 亚太传统医药, 2020, 16(1): 200-203.
Li LL, Li X. Preventive and therapeutic role of baicalin in periodontitis: a literature review[J]. Asia Pac Tradit Med, 2020, 16(1): 200-203.
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