Int J Stomatol ›› 2021, Vol. 48 ›› Issue (3): 341-346.doi: 10.7518/gjkq.2021037

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Mechanism of sirtuin 1 in regulating periodontitis

Zhou Feng1(),Chen Ye1,Chen Chen2,Zhang Yining2,Geng Ruiman2,Liu Ji2()   

  1. 1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & West China School of Stomatology, Sichuan University, Chengdu 610041, China
    2. West China School of Basic Medical Science and Forensic Medicine, Sichuan University, Chengdu 610041, China
  • Received:2020-08-16 Revised:2020-12-24 Online:2021-05-01 Published:2021-05-14
  • Contact: Ji Liu;


Periodontitis is a species of inflammatory, destructive diseases that occur in periodontal tissues. As the starting factor of periodontitis, dental plaque mediates oxidative stress and secondary inflammation, which leads to tissue destruction, alveolar bone absorption, and tooth loosening and loss. Sirtuin 1 (SIRT1), an important longevity factor, plays a vital role in antiaging and antistress applications, mediating apoptosis, autophagy, and regulating inflammation reaction. In recent years, several studies explored the relationship between SIRT1 and the occurrence and development of periodontitis from multiple perspectives, such as oxidative stress, inflammatory factors and pathways, and systemic diseases. This study reviews the relationship between SIRT1 and periodontitis, the possible mechanism, and its future clinical application to provide reference.

Key words: sirtuin 1, periodontitis, oxidative stress, inflammation, autophagy

CLC Number: 

  • R782

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