Int J Stomatol

Int J Stomatol ›› 2023, Vol. 50 ›› Issue (6): 686-695.doi: 10.7518/gjkq.2023095

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Regenerative endodontic procedures for permanent tooth with immature apices in adult patients

Hu Jia(),Wang Xiuqing,Lu Guoying,Huang Xiaojing.()   

  1. Dept. of Cariology and Endodontics, School and Hospital of Stomatology, Fujian Medical University & Fujian Key Laboratory of Oral Diseases & Fujian Provincial Engineering Research Center of Oral Biomaterials & Stomatological Key Laboratory of Fujian College and University & Stomatology Institute of Fujian Medical University, Fuzhou 350002, China
  • Received:2023-03-13 Revised:2023-07-29 Online:2023-11-01 Published:2023-10-24
  • Contact: Xiaojing. Huang E-mail:xiaofeixia_hu@163.com;hxiaoj@163.com
  • Supported by:
    the Education and Scientific Research Project in Fujian Province(JAT200129)

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Abstract:

Regenerative endodontic procedures have been used to treat infected immature permanent teeth in children and adolescents to achieve continued root development and dentin-pulp complex formation. Treating the infected teeth of adult patients with immature apices is challenging. Current treatments form physical barriers by apexification or apical barrier technique. Although teeth can be saved, they are devitalized and become susceptible to reinfections and fractures. With the development of tissue engineering and biomaterials, researchers have tried to save the immature permanent teeth of adults by regeneration. Here, the clinical efficacy of regenerative endodontic procedures is analyzed to explore whether they should be developed for dental pulp and/or dentin regeneration in adults with immature apices.

Key words: regenerative endodontic procedures, permanent teeth, immature apices, periapical periodontitis

CLC Number: 

  • R 781

TrendMD: 

Tab 1

Summary of studies on REPs in mature permanent teeth"

作者研究类型（病例数）年龄/岁牙位支架根管预备症状消失根尖暗影牙髓活力随访时间/月
冷测电活力
Machut等[16]病例报告 （2）45、4223PRF+GP机械预备是缩小--6
Brizuela等[12]随机对照（18/36）*16~58前牙/前磨牙

BC+

UC-MSCs

机械预备是愈合/缩小 （100%）▲+（56%）+（50%）12
El-Kateb等[21]随机对照（18）*20~34前牙BC#30/#50是愈合/缩小 （100%）▲+（83%）+（77%）12
Arslan等[19]随机对照（26/46）*18~30单根牙BC#45~#80是愈合/缩小 （92.3%）▲NM+（50%）12
Nageh等[23]临床研究 （15）18~4011/21BC+PRF#60~#80是愈合+（60%）+（100%）12
Saoud等[24]病例报告 （7）8~21前牙/磨牙BC#25~#40是愈合/缩小 （100%）▲--8~26
Saoud等[18]病例报告 （1）2312BC#35是缩小--12
Paryani等[17]病例报告 （2）11、1411/21BC#60是愈合NM+（50%）18、22
Shah等[15]临床研究 （18）15~76前牙/磨牙BC#25~#30是愈合/缩小 （100%）△--6~36

Tab 2

Studies on adult immature permanent teeth treated with REPs"

作者研究类型

病例

数

年龄/岁牙位再治疗牙根发育*支架机械预备症状消失根尖暗影牙根变化牙髓活力随访时间/月
Nosrat等[25]病例报告11821是9BC+PRF少量是愈合根尖闭合-12
Neelamurthy等[26]临床研究918~35单根牙否8~9BC无是愈合/缩小 （100%）

根尖闭合/牙根

发育（66.7%）

+（1）10
Gavi?o Ordu?a等[27]病例报告321~35前牙是（1）8~9BC+PRP少量是愈合根尖闭合（1）/根长少量增加（1）NM50
Zhujiang等[28]病例报告12037否8BC+rh-PDGF-BB少量是愈合根尖闭合+15
Nevins等[29]病例报告428~48前牙/前磨牙是9BC少量是缩小根尖闭合（1）NM12
Saoud等[30]病例报告12621是9BC#60是缩小

根尖闭合，管壁

增厚

-13
Saoud等[18]病例报告12311否9BC#100是缩小

根尖闭合，管壁

增厚

-12
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