Int J Stomatol ›› 2020, Vol. 47 ›› Issue (2): 225-234.doi: 10.7518/gjkq.2020048

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Progress in pathogenic factors and mechanisms of Enterococcus faecalis in oral and systemic diseases

Shui Yusen1,Lü Xiaoying1,Li Jingya1,Yang Ran2()   

  1. 1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & West China School of Stomatology, Sichuan University, Chengdu 610041, China
    2. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2019-05-05 Revised:2019-09-10 Online:2020-03-01 Published:2020-03-12
  • Contact: Ran Yang E-mail:yangran@scu.edu.cn
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81800989)

Abstract:

Enterococcus faecalis (E. faecalis) is the main pathogen of root canal reinfection and persistent periapical periodontitis in human oral cavity. This species can survive for a long time in the harsh environment of a root canal. E. faecalis has a certain resistance to most root canal therapy drugs, as well as cleaning and disinfection methods. This species presents a major challenge in root canal therapy at present. In addition, E. faecalis is associated with some systemic infections, such as gastrointestinal and urinary tract infection. Its pathogenesis is related to its initial adhesion to the host, biofilm formation, invasive infection, and immune escape. E. faecalis expresses various proteins, glycolipids, and other adhesion to achieve initial adhesion. This species can regulates the expression of various biofilm-associated genes to form a mature biofilm to fight against the body’s deterioration, and realize the communication between cells subsequently. Eventually, E. faecalis colonizes a local area or even the whole body to cause infection. The present review focuses on the pathogenic factors and pathogenesis of E. faecalis.

Key words: Enterococcus faecalis, root canal reinfection, persistent periapical periodontitis, systemic infection

CLC Number: 

  • R780.2

TrendMD: 
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