Int J Stomatol

Int J Stomatol ›› 2023, Vol. 50 ›› Issue (5): 613-617.doi: 10.7518/gjkq.2023073

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Research progress on mechanism of Enterococcus faecalis escaping host immune defense

Xu Zhibo(),Meng Xiuping.()   

  1. Dept. of Cariology and Endodontics, Hospital of Stomatology, Jilin University, Changchun 130021, China
  • Received:2022-10-15 Revised:2023-03-06 Online:2023-09-01 Published:2023-09-01
  • Contact: Xiuping. Meng E-mail:xuzb21@mails.jlu.edu.cn;mengxp@jlu.edu.cn

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Abstract:

Enterococcus faecalis is the main pathogenic bacteria in persistent apical periodontitis, which contains a variety of virulence factors. The host immune defense can mobilize a variety of immune cells and immune molecules in the body to regulate the body’s inflammatory response, which can play an important role in persistent periapical periodontitis caused by Enterococcus faecalisis. However, in the process of invading the body, Enterococcus faecalisis can form a va-riety of mechanisms to escape host defense immunity, so that it can survive in the host and cause damage. This article will review the research progress on the immune defense mechanism of Enterococcus faecalisis escaping the host, aiming to explore why Enterococcus faecalisis cannot be cleared in the periapical tissue from the perspective of immunity, in order to provide new information for the prevention and treatment of persistent periapical periodontitis idea.

Key words: Enterococcus faecalis, immune evasion, periodontitis

CLC Number: 

  • Q 939.93

TrendMD: 
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