Int J Stomatol ›› 2023, Vol. 50 ›› Issue (1): 25-31.doi: 10.7518/gjkq.2023013

• Periodontitis • Previous Articles     Next Articles

Research progress on resveratrol for the treatment of periodontitis and its bioavailability

Li Qiong1(),Yu Weixian1,2()   

  1. 1.Dept. of Periodontology, Hospital of Stomatology, Jilin University, Changchun 130021, China
    2.Jilin Provincial Key Laboratory of Tooth Development and Bone Remodeling, Changchun 130021, China
  • Received:2022-05-25 Revised:2022-09-21 Online:2023-01-01 Published:2023-01-09
  • Contact: Weixian Yu;
  • Supported by:
    Science and Technology Project of Jilin Provincial Department of Finance(JCSZ2021-893-22)


Resveratrol is a natural polyphenol compound that has extensive pharmacological activities and can be found in plants, such as dark grapes, berries, and peanut skins. Experimental studies showed that it plays a therapeutic role in periodontitis, such as anti-inflammation, anti-oxidation, anti-bacteria, inhibition of bone resorption, and promotion of bone formation. However, resveratrol also faces some problems, such as rapid absorption, low bioavailability, and low water solubility. The improvement of cosolvent and the use of nanoparticles can solve these problems. This article reviews the research progress on resveratrol for the treatment of periodontitis and its bioavailability to provide reference for further research on resveratrol as a therapeutic drug and the development of suitable drug dosage forms.

Key words: resveratrol, periodontitis, bioavailability

CLC Number: 

  • R 781.4


Fig 1

Structural formula of trans-resveratrol (top) and cis-resveratrol (bottom)"

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