Int J Stomatol ›› 2022, Vol. 49 ›› Issue (3): 343-348.doi: 10.7518/gjkq.2022059

• Reviews • Previous Articles     Next Articles

Research progress on adenosine monophosphate-activated protein kinase in periodontal disease

Li Guiping(),Qin Xu,Zhu Guangxun.()   

  1. Dept. of Stomatology, Tongji Hospital, Tongji Medical College, Huazhong University of Science and Technology, Wuhan 430030, China
  • Received:2021-08-05 Revised:2021-12-02 Online:2022-05-01 Published:2022-05-09
  • Contact: Guangxun. Zhu;
  • Supported by:
    National Natural Science Foundation of China(81300883);Natural Science Foundation of Hubei Province(2019CFB688)


Periodontal disease is characterized by the pathological resorption of periodontal support tissue caused by the interaction of specific pathogenic bacteria and destructive immune response. As a key regulator of cellular energy, adenosine monophosphate-activated protein kinase (AMPK) participates in the regulation of the metabolism of fatty acids and glucose in important tissues and organs to maintain body homeostasis, and it has been studied extensively in metabolic diseases. Previous studies showed that AMPK can also participate in regulating periodontal bone metabolism, immune response, matrix metalloproteinase secretion, and cellular autophagy to regulate the occurrence and development of periodontal diseases, revealing the potential role of AMPK in the pathogenesis of periodontal disease and providing a new therapeutic target for its treatment. This review provides an overview of the research progress of AMPK in periodontal diseases.

Key words: periodontal disease, adenosine monophosphate-activated protein kinase, matrix metalloproteinases, inflammation, autophagy

CLC Number: 

  • R 781.4

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