Int J Stomatol ›› 2021, Vol. 48 ›› Issue (5): 528-535.doi: 10.7518/gjkq.2021102

• Original Articles • Previous Articles     Next Articles

Effects of non-surgical periodontal treatment on risk factors of chronic kidney disease and systematic inflammatory levels in patients with chronic kidney disease and periodontal disease: a Meta-analysis

Zhou Wanhang1(),Li Yanfei2,Xu Ricong3,Wan Qijun3()   

  1. 1. School of Stomatology, China Medical University, Liaoning Provincial Key Laboratory of Oral Diseases, Shenyang 110000, China
    2. Dept. of Prosthodontics, Guanghua School of Stomatology, Hospital of Stomatology, Sun Yat-sen University, Guangdong Provincial Key Laboratory of Stomatology, Guangzhou 510055, China
    3. Dept. of Kidney, The First Affiliated Hospital of Shenzhen University, Shenzhen Second People,s Hospital, Shenzhen 518000, China
  • Received:2021-03-03 Revised:2021-06-12 Online:2021-09-01 Published:2021-09-10
  • Contact: Qijun Wan;
  • Supported by:
    National Natural Science Foundation of China(81900639);Shenzhen Key Medical Discipline Construction Fund(SZXK009)


Objective The aim of this study was to evaluate the effects of non-surgical periodontal treatment on risk factors of chronic kidney disease (CKD) and systemic inflammatory levels in patients with CKD and periodontal disease so as to provide a theoretical reference for co-management. Methods Eligible studies as of July 2020 were searched systematically in PubMed, Embase, Cochrane Library, S-cience Direct, Scopus, Web of Scienc, CNKI, Wanfang, and VIP. Two independent reviewers screened the literature, evaluated the quality of the studies, extracted the data, and evaluated the risk of bias of the included stu-dies in duplicate. Meta-analysis was then conducted with RevMan 5.3. Results Six randomized controlled trials involving 432 participants were included. Meta-analysis showed that compared with the control group, the patients who received non-surgical periodontal treatment had lower 24-hour urinary protein quantity [MD=-0.32, 95% CI (-0.50, -0.14), P=0.000 4], serum C-reactive protein (CRP) in patients under 45 years old [MD=-1.25, 95% CI (-1.38, -1.12), P<0.000 01], serum interleukin-6 (IL-6) after 3 and 6 months of treatment [MD=-0.82, 95% CI (-1.64, 0.00), P=0.05; MD=-1.17, 95% CI (-2.05, -0.30), P=0.009], and higher serum albumin (Alb) [MD=0.19, 95% CI (0.11, 0.27), P<0.000 01]. Meanwhile, the changes in serum CRP in patients over 45 years old [MD=-0.06, 95% CI (-0.48, 0.36), P=0.77] and serum IL-6 after 6 weeks of treatment [MD=-0.24, 95% CI (-1.14, 0.67), P=0.61] had no statistically significant difference between the two groups. Conclusion Non-surgical periodontal treatment has favorable effects on controlling 24-hour urinary protein quantity and serum Alb and reducing systemic inflammatory (CRP and IL-6) levels in patients under 45 years old.

Key words: non-surgical periodontal treatment, chronic kidney disease, periodontal disease, Meta-analysis, systematic review

CLC Number: 

  • R781.4


Fig 1

Screaning process"

Tab 1


纳入研究 国家 样本量
牙周干预措施 随访时间 主要结局指标
Guo等[14] 中国 26/27 24/29 58.1±8.4/56.9±8.5 NSPT+OHI OHI 6周 ③④
Fang等[15] 中国 48/49 55/42 53.71±5.89/55.53±6.74 NSPT+OHI+EXT N 6周,3、6个月 ①④
Wehmeyer等[13] 美国 25/26 33/18 52.7±10.6/54.1±9.0 NSPT+OHI+EXT+AT OHI 3、6个月 ①④
李浩萍等[16] 中国 36/36 39/33 40.28±6.30/39.87±6.13 NSPT+OHI N 8周 ②③
马欣等[17] 中国 52/46 56/42 39.2±5.2 NSPT+OHI N 6周 ②③
张晋玮等[18] 中国 31/30 30/31 48.87±4.74/48.35±4.53 NSPT+OHI N 1个月

Tab 2


纳入研究 随机分组 分配隐藏 盲法 随访偏倚 报告偏倚 其他偏倚
Guo等[14] 不清楚 不清楚 不清楚
Fang等[15] 随机数字表 双盲
Wehmeyer等[13] 随机数字表
李浩萍等[16] 不清楚 不清楚 不清楚
马欣等[17] 不清楚 不清楚 不清楚
张晋玮等[18] 随机数字表 不清楚 不清楚

Fig 2

Results of the Meta-analysis on 24-hour urinary protein for the two groups"

Fig 3

Results of the Meta-analysis on Alb for the two groups"

Fig 4

Results of the Meta-analysis on serum CRP for the two groups"

Fig 5

Results of the Meta-analysis on serum IL-6 for the two groups"

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