Int J Stomatol

Int J Stomatol ›› 2023, Vol. 50 ›› Issue (4): 438-444.doi: 10.7518/gjkq.2023049

• Original Articles • Previous Articles     Next Articles

Postoperative infection control effect of povidone iodine and chlorhexidine: a systematic review and analysis

Wang Lüya(),Zhang Jingxin,Lin Jie.()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Di-seases & Dept. of Implantology, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2022-09-05 Revised:2023-03-02 Online:2023-07-01 Published:2023-06-21
  • Contact: Jie. Lin E-mail:1905768051@qq.com;84204362@qq.com
  • Supported by:
    Scientific Research Project of Science and Technology Department of Sichuan Province(2022JDKP0085)

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Abstract:

Objective This study aimed to compare the effect of chlorhexidine and povidone iodine in controlling oral postoperative infection through systematic review and meta-analysis. Methods By combining free-word retrieval and subject retrieval, the databases of PubMed, Embase, Web of Science, Cochrane Library, CNKI, VIP, and Wanfang were retrieved. The retrieval period was from the establishment of databases to May 2022. After literature screening, data ex-traction, and quality evaluation were independently completed, Review Manager 5.3 software was used for the meta-analysis. Results A total of 12 articles were included, and the risk of bias was found to be moderate. The meta-analysis showed that the control effect of chlorhexidine and povidone iodine after oral surgery was similar, without significant difference (P>0.05). However, the subjective feeling of using povidone iodine was better than that of chlorhexidine, and the difference was statistically significant (P<0.000 01). Conclusion No difference was observed in the infection control effect between chlorhexidine and povidone iodine after oral surgery. Povidone iodine had better subjective feeling than chlorhexidine.

Key words: oral postoperative, povidone iodine, chlorhexidine, the control of infection, systematic review

CLC Number: 

  • R 78

TrendMD: 

Fig 1

Flowchart for literature search"

Tab 1

Characteristics of the included literature"

纳入文献手术类型患者数（试验/对照）性别/例（男/女）年龄药物使用方式随访时间结局指标
试验组对照组
彭根英等[5]（2013）口腔颌面部外科手术647（349/298）0.12%醋酸氯己定0.1%聚维酮碘术前1 d含漱2次，术前30 min~1 h 含漱1次；术后每天2次，每次20 mL，时间1~3 min1个月，有植入物者1年①
王立新等[6]（2014）牙拔除术后96（48/48）7~69岁0.2%复方氯己定0.05%聚维酮碘术后含漱，每天2次7 d①③
申宝红等[7]（2018）口腔癌术后60（30/30）60（37/23）17~91岁复方氯己定

0.5%聚

维酮碘

术后24 h后开始使用，每天3次，每次60 mL至拆除黏膜缝线②③
徐逢源等[8]（2019）口腔种植体植入术40（20/20）0.1%复方氯己定1%聚维酮碘

氯己定：餐后漱口3次，每次10~15 mL，120 s

聚维酮碘：餐后漱口1次，每次 10~15 mL，20 s

14 d③④⑤
叶春艳[9]（2019）口腔颌面外科手术250（125/125）250（125/125）11个月~87岁0.12%醋酸氯己定

0.1%聚

维酮碘

术前1 d含漱2次，术前30 min~1 h含漱1次；术后每天2次，每次20 mL，1~3 min1年①
Polat等[10]（2008）第三磨牙拔除术32（16/16）32（16/16）0.2%葡萄糖酸氯己定

7.5%聚

维酮碘

术后每天2次，每次1 min术后3、8、15 d②
Mohanty等[11]（2022）第三磨牙拔除术100（50/50）0.2%葡萄糖酸氯己定1%聚维酮碘术中冲洗，每天2次，每次2 mL2、7 d①⑤
Akbulut[12]（2020）正畸支抗钉植入19（9/10）19（9/10）试验组：（18.58±1.93）岁；对照组：（18.24±1.57）岁0.12%葡萄糖酸氯己定

7.5%聚

维酮碘

21 d③④
Kosutic等[13]（2009）口腔颌面部外科手术60（30/30）1%葡萄糖酸氯己定1%聚维酮碘术前含漱7 d①③
Tuna等[14]（2012）下颌第三磨牙拔除术24（12/12）24（9/15）0.2%氯己定

7.5%聚

维酮碘

术前，15 mL漱口1 min7 d①
Managutti等[15]（2017）下颌第三磨牙拔除术20（10/10）0.2%氯己定5%聚维酮碘术前，15 mL漱口1 min1、2、7 d①
Jadhao等[16] （2018）下颌第三磨牙拔除术32（16/16）24~31岁0.02%葡萄糖酸氯己定

0.5%聚

维酮碘

术前冲洗7 d①⑤

Tab 2

Risk bias assessment of the included literature"

纳入文献随机序列生成随机分配隐藏受试者与干预者盲法结局评价者盲法不完整的结局报告选择性报告其他偏倚分级
彭根英等[5]（2013）低风险不清楚不清楚不清楚低风险低风险不清楚B
王立新等[6]（2014）不清楚不清楚不清楚不清楚低风险低风险不清楚B
申宝红等[7]（2018）不清楚不清楚不清楚不清楚低风险低风险不清楚B
徐逢源等[8]（2019）低风险不清楚高风险不清楚低风险低风险不清楚B
叶春艳[9]（2019）低风险不清楚不清楚不清楚低风险低风险不清楚B
Polat等[10]（2008）低风险不清楚不清楚低风险低风险低风险不清楚B
Mohanty等[11]（2022）低风险不清楚不清楚不清楚低风险低风险不清楚B
Akbulut[12]（2020）不清楚不清楚不清楚不清楚低风险低风险不清楚B
Kosutic等[13]（2009）不清楚不清楚低风险不清楚低风险低风险不清楚B
Tuna等[14]（2012）低风险低风险低风险低风险低风险低风险不清楚A
Managutti等[15]（2017）高风险不清楚不清楚不清楚低风险低风险不清楚B
Jadhao等[16] （2018）不清楚不清楚不清楚不清楚低风险低风险不清楚B

Fig 2

Postoperative infection rate of chlorhexidine and povidone iodine after oral surgery"

Fig 3

Postoperative infection rate of chlorhexidine and povidone iodine before oral surgery"

Fig 4

Number of oral bacterial colonies of chlorhexidine and povidone iodine after oral surgery"

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