Int J Stomatol ›› 2022, Vol. 49 ›› Issue (2): 244-248.doi: 10.7518/gjkq.2022019

• Reviews • Previous Articles    

Research progress on the relationship between new anti-inflammatory factor developmental endothelial locus-1 and periodontitis

Jiang Duan(),Shen Daonan,Zhao Lei,Wu Yafei()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2021-06-12 Revised:2021-11-25 Online:2022-03-01 Published:2022-03-15
  • Contact: Yafei Wu;


Periodontitis is a chronic infectious disease. As initial factors of periodontitis, plaque microorganisms and their products can destroy periodontal tissue directly and indirectly affect the process of periodontitis by affecting host immune response. Developmental endothelial locus-1(DEL-1) is a secretory multi-domain protein that regulates different stages of host inflammatory response according to its expression location. DEL-1 is involved in the regulation of neutrophil recruitment at the initial stage of periodontitis and can induce inflammation resolution, which can inhibit alveolar bone resorption and promote new bone formation. This article reviews the research on the role of new anti-inflammatory factor DEL-1 in the regulation of periodontitis.

Key words: developmental endothelial locus-1, periodontitis, neutrophil, inflammation resolution, alveolar bone resorption

CLC Number: 

  • R781.4

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