Inter J Stomatol ›› 2018, Vol. 45 ›› Issue (5): 597-602.doi: 10.7518/gjkq.2018.05.017

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Long non-coding RNA associated with p53 and the relationship with tumor

Tongtong Han,Qiaoer Chen(),Youming. Zhu   

  1. School of Stomatology, Anhui Medical University, Hefei 230032, China
  • Received:2017-10-22 Revised:2018-03-09 Online:2018-09-01 Published:2018-09-20
  • Contact: Qiaoer Chen E-mail:chqe0111@163.com

Abstract:

p53 gene is a negative regulator of cell growth which can suppress the tumor through the regulation of cell proliferation and apoptosis under normal circumstances. The mutation of p53 often lead to the tumorigenesis. Recently, Long non-coding RNA (lncRNA) was identified as having a function role in the tumorigenesis and development of a variety of tumors. The review aimed to discuss the relationship of LncRNA which associated with p53 and oral cancer, and provide new strategies for patients with oral cancer.

Key words: p53, long non-coding RNA, tumors, oral cancer

CLC Number: 

  • R782

TrendMD: 
[1] 云霞, 达林泰, 田玮 , 等. 口腔鳞癌中β-catenin和p53蛋白的表达及其临床意义[J]. 内蒙古医学杂志, 2015,47(4):385-388, 514.
doi: 10.16096/J.cnki.nmgyxzz.2015.47.04.001
Yun X, Da LT, Tian W , et al. Expression of β-ca-tenin and p53 protein in oral squamous cell carcinoma and their clinical significance[J]. Inner Mongolia Med J, 2015,47(4):385-388, 514.
doi: 10.16096/J.cnki.nmgyxzz.2015.47.04.001
[2] Melo CA, Léveillé N, Rooijers K , et al. A p53-bound enhancer region controls a long intergenic noncoding RNA required for p53 stress response[J]. Oncogene, 2016,35(33):4399-4406.
doi: 10.1038/onc.2015.502
[3] 冯昭飞, 陈瑞扬 . p53基因突变与口腔肿瘤关系的研究进展[J]. 医学综述, 2008,14(14):2113-2115.
doi: 10.3969/j.issn.1006-2084.2008.14.011
Feng ZF, Chen RY . Study progress of the relationship between p53 gene mutation and oral tumor[J]. Med Recap, 2008,14(14):2113-2115.
doi: 10.3969/j.issn.1006-2084.2008.14.011
[4] Zhai N, Xia Y, Yin R , et al. A negative regulation loop of long noncoding RNA HOTAIR and p53 in non-small-cell lung cancer[J]. Onco Targets Ther, 2016,9:5713-5720.
doi: 10.2147/OTT
[5] 王莹, 辛彦 . Hippo通路和相关长链非编码RNA(LncRNA)与肿瘤关系的研究进展[J]. 现代肿瘤医学, 2015,23(21):3190-3193.
Wang Y, Xin Y . Hippo signal pathway and related LncRNA in tumors[J]. J Modern Oncol, 2015,23(21):3190-3193.
[6] Mercer TR, Dinger ME, Mattick JS , Long non-coding RNAs: insights into functions[J]. Nat Rev Genet, 2009,10(3):155-159.
doi: 10.1038/nrg2521
[7] Spizzo R, Almeida MI, Colombatti A , et al. Long non-coding RNAs and cancer: a new frontier of tran-slational research[J]. Oncogene, 2012,31(43):4577-4587.
doi: 10.1038/onc.2011.621 pmid: 22266873
[8] 徐伟华 . 长链非编码RNA URHC在肝癌细胞增殖与凋亡中的作用及机制研究[D]. 西安: 第四军医大学, 2014.
Xu WH . The function and mechanism of long non-coding RNA URHC on cell proliferation and apopto-sis in human hepatoma cells[D]. Xi’an: The Fourth Military Medical University, 2014.
[9] Gupta RA, Shah N, Wang KC , et al. Long non-coding RNA HOTAIR reprograms chromatin state to promote cancer metastasis[J]. Nature, 2010,464(7291):1071-1076.
doi: 10.1038/nature08975 pmid: 3049919
[10] Hou P, Zhao Y, Li Z , et al. LincRNA-ROR induces epithelial-to-mesenchymal transition and contributes to breast cancer tumorigenesis and metastasis[J]. Cell Death Dis, 2014,5(6):e1287-e1287.
doi: 10.1038/cddis.2014.249
[11] 陈沁楠, 王朝霞 . 长链非编码 RNA GAS5在肿瘤研究中的进展[J]. 现代肿瘤医学, 2016,24(1):138-140.
doi: 10.3969/j.issn.1672-4992.2016.01.040
Chen QN, Wang ZX . Advancements of long non- coding RNA GAS5 in tumor research[J]. J Modern Oncol, 2016,24(1):138-140.
doi: 10.3969/j.issn.1672-4992.2016.01.040
[12] Grossi E, Sánchez Y, Huarte M , Expanding the p53 regulatory network: LncRNAs take up the challenge[J]. Biochim Biophys Acta, 2016,1859(1):200-208.
doi: 10.1016/j.bbagrm.2015.07.011 pmid: 26196323
[13] 魏晨晨, 王朝霞 . 长链非编码RNA H19在肿瘤研究中的进展[J]. 临床肿瘤学杂志, 2015,20(11):1041-1044.
Wei CC, Wang ZX . Progression of long non-coding RNA H19 in tumors[J]. Chin Clin Oncol, 2015,20(11):1041-1044.
[14] Adriaenssens E, Dumont L, Lottin S , et al. H19 over-expression in breast adenocarcinoma stromal cells is associated with tumor values and steroid receptor status but independent of p53 and Ki-67 expression[J]. Am J Pathol, 1998,153(5):1597-1607.
doi: 10.1016/S0002-9440(10)65748-3
[15] Yang F, Bi JW, Xue XC , et al. Up-regulated long non-coding RNA H19 contributes to proliferation of gastric cancer cells[J]. FEBS J, 2012,279(17):3159-3165.
doi: 10.1111/j.1742-4658.2012.08694.x
[16] Liu FT, Pan H, Xia GF , et al. Prognostic and clinico-pathological significance of long noncoding RNA H19 overexpression in human solid tumors: evidence from a meta-analysis[J]. Oncotarget, 2016,7(50):83177-83186.
[17] Zhang J, Zhang P, Wang L , et al. Long non-coding RNA HOTAIR in carcinogenesis and metastasis[J]. Acta Biochim Biophys Sin, 2014,46(1):1-5.
doi: 10.1093/abbs/gmt117
[18] Yu X, Li Z , Long non-coding RNA HOTAIR: a novel oncogene (review)[J]. Mol Med Rep, 2015,12(4):5611-5618.
doi: 10.3892/mmr.2015.4161 pmid: 26238267
[19] Liu YW, Sun M, Xia R , et al. LincHOTAIR epi-genetically silences miR34a by binding to PRC2 to promote the epithelial-to-mesenchymal transition in human gastric cancer[J]. Cell Death Dis, 2015,6(7):e1802.
doi: 10.1038/cddis.2015.150
[20] Hu DM, Su CJ, Jiang M , et al. Fenofibrate inhibited pancreatic cancer cells proliferation via activation of p53 mediated by upregulation of LncRNA MEG3[J]. Biochem Biophys Res Commun, 2016,471(2):290-295.
doi: 10.1016/j.bbrc.2016.01.169
[21] Zhu JJ, Liu SS, Ye FQ , et al. Long noncoding RNA MEG3 interacts with p53 protein and regulates partial p53 target genes in hepatoma cells[J]. PloS One, 2015,10(10):e0139790.
doi: 10.1371/journal.pone.0139790
[22] Zhang J, Lin ZQ, Gao YL , et al. Downregulation of long noncoding RNA MEG3 is associated with poor prognosis and promoter hypermethylation in cervical cancer[J]. J Exp Clin Cancer Res, 2017,36(1):5.
doi: 10.1186/s13046-016-0472-2
[23] Chen RP, Huang ZL, Liu LX , et al. Involvement of endoplasmic reticulum stress and p53 in lncRNA MEG3-induced human hepatoma HepG2 cell apoptosis[J]. Oncol Rep, 2016,36(3):1649-1657.
doi: 10.3892/or.2016.4919
[24] Zhan HX, Wang Y, Li C , et al. LincRNA-ROR pro-motes invasion, metastasis and tumor growth in pan-creatic cancer through activating ZEB1 pathway[J]. Cancer Lett, 2016,374(2):261-271.
doi: 10.1016/j.canlet.2016.02.018
[25] Chen YM, Liu Y, Wei HY , et al. Linc-ROR induces epithelial-mesenchymal transition and contributes to drug resistance and invasion of breast cancer cells[J]. Tumor Biol, 2016,37(8):10861-10870.
doi: 10.1007/s13277-016-4909-1
[26] Chen SA, Ma PP, Zhao Y , et al. Biological function and mechanism of MALAT-1 in renal cell carcinoma proliferation and apoptosis: role of the MALAT-1-Livin protein interaction[J]. J Physiol Sci, 2016,67(5):577-585.
[27] Huang JK, Ma L, Song WH , et al. MALAT1 promotes the proliferation and invasion of thyroid cancer cells via regulating the expression of IQGAP1[J]. Biomed Pharmacother, 2016,83:1-7.
doi: 10.1016/j.biopha.2016.05.039
[28] Yao WJ, Bai Y, Li Y , et al. Upregulation of MALAT-1 and its association with survival rate and the effect on cell cycle and migration in patients with esophageal squamous cell carcinoma[J]. Tumor Biol, 2015,37(4):4305-4312.
[29] Han T, Jiao F, Hu H , et al. EZH2 promotes cell mi-gration and invasion but not alters cell proliferation by suppressing E-cadherin, partly through association with MALAT-1 in pancreatic cancer[J]. Oncotarget, 2016,7(10):11194-11207.
[30] Zhang Y, Wang T, Huang HQ , et al. Human MALAT-1 long non-coding RNA is overexpressed in cervical cancer metastasis and promotes cell proliferation, in- vasion and migration[J]. J BUON, 2015,20(6):1497-1503.
[31] Chang SM, Hu WW , Long non-coding RNA MALAT1 promotes oral squamous cell carcinoma development via microRNA-125b/STAT3 axis[J]. J Cell Physiol, 2017,233(4):3384-3396.
[32] Zhou X, Liu S, Cai G , et al. Long Non coding RNA MALAT1 promotes tumor growth and metastasis by inducing epithelial-mesenchymal transition in oral squamous cell carcinoma[J]. Sci Rep, 2015,5:15972.
doi: 10.1038/srep15972
[33] Zhang TH, Liang LZ, Liu XL , et al. Long non-coding RNA MALAT1 interacts with miR-124 and modulates tongue cancer growth by targeting JAG1[J]. Oncol Rep, 2017,37(4):2087-2094.
doi: 10.3892/or.2017.5445
[34] Fang Z, Zhang S, Wang Y , et al. Long non-coding RNA MALAT-1 modulates metastatic potential of tongue squamous cell carcinomas partially through the regulation of small proline rich proteins[J]. BMC Cancer, 2016,16:706.
doi: 10.1186/s12885-016-2735-x
[35] Wu YS, Zhang L, Zhang L , et al. Long non-coding RNA HOTAIR promotes tumor cell invasion and metastasis by recruiting EZH2 and repressing E-cad-herin in oral squamous cell carcinoma[J]. Int J Oncol, 2015,46(6):2586-2594.
doi: 10.3892/ijo.2015.2976
[36] Liu H, Li Z, Wang C , et al. Expression of long non-coding RNA-HOTAIR in oral squamous cell carcinoma Tca8113 cells and its associated biological behavior[J]. Am J Transl Res, 2016,8(11):4726-4734.
[37] Jia LF, Wei SB, Gan YH , et al. Expression, regulation and roles of miR-26a and MEG3 in tongue squamous cell carcinoma[J]. Int J Cancer, 2014,135(10):2282-2293.
doi: 10.1002/ijc.28667 pmid: 24343426
[38] Liu ZX, Wu C, Xie NN , et al. Long non-coding RNA MEG3 inhibits the proliferation and metastasis of oral squamous cell carcinoma by regulating the WNT/β-catenin signaling pathway[J]. Oncol Lett, 2017,14(4):4053-4058.
doi: 10.3892/ol.2017.6682
[39] Zhang DM, Lin ZY, Yang ZH , et al. IncRNA H19 promotes tongue squamous cell carcinoma progression through β-catenin/GSK3β/EMT signaling via asso-ciation with EZH2[J]. Am J Transl Res, 2017,9(7):3474-3486.
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