Int J Stomatol ›› 2020, Vol. 47 ›› Issue (5): 515-521.doi: 10.7518/gjkq.2020080

• Oral Microecology • Previous Articles     Next Articles

Progress on the application of probiotics in the management of periodontal diseases

Jia Leming1(),Jia Xiaoyue2,Yang Ran2,Zhou Xuedong1,Xu Xin1()   

  1. 1.State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Cariology and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
    2.State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Pediatric Dentistry, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2020-01-05 Revised:2020-04-02 Online:2020-09-01 Published:2020-09-16
  • Contact: Xin Xu;
  • Supported by:
    National Natural Science Foundation of China(81870754);National Natural Science Foundation of China(81800989);Program Funded by Science and Technology Department of Sichuan Province(2018SZ0121)


Periodontal diseases, which can seriously damage the structures that surround the teeth, including gums, perio-dontal ligament, and alveolar bone, are the major causes of tooth loss among adults. Approximately 80%-90% of adults in China are suffering from different degrees of periodontal diseases. The etiology of periodontal diseases is complicated, but periodontal micro dysbiosis and abnormal host immune response are recognized as the important causes of these diseases. The basic treatment of these diseases includes the mechanical removal of calculus and plaque and systemic and topical medications. Several drugs that modulate periodontal microbial ecology and immune abnormality have emerged because of the re-colonization of oral pathogens and the incidence of antibacterial resistance. Probiotics have been used to address intestinal microbial dysbiosis, and their application in the treatment of oral infectious diseases has also been suggested. This article reviewed the progress on the research and application of probiotics in the treatment of periodontal diseases to provide a new paradigm for the ecological management of these diseases.

Key words: periodontal diseases, probiotics, oral microecology, periodontal microecology

CLC Number: 

  • R781.4


Tab 1

Classification of probiotics for use in humans approved by National Health Commission of the People’s Republic of China"

菌属 菌种名称
乳杆菌属 德氏乳杆菌(Lactobacillus delbrueckii)、短乳杆菌(Latobacillus brevis)、嗜酸乳杆菌(Lactobacillus acidophilus)、保加
利亚乳杆菌(Lactobacillus bulgaricus)、干酪乳杆菌(Lactobacillus casei)、发酵乳杆菌(Lactobacillus fermentium)、植
物乳杆菌(Lactobacillus plantarum)、鼠李糖乳杆菌(Lactobacillus rhamnosus)等
双歧杆菌属 青春双歧杆菌(Bifidobacterium adolescentis)、长双歧杆菌(Bifidobacterium longum)、短双歧杆菌(Bifidobacterium
breve)、嗜热双歧杆菌(Bifidobacterium thermophilum)、乳双歧杆菌(Bifidobacterium lactis)等
肠球菌属 粪肠球菌(Enterococcus faecalis)、屎肠球菌(Enterococcus faecium)等
链球菌属 嗜热链球菌(Streptococcus thermophilus
芽孢杆菌属 枯草芽孢杆菌(Bacillus subtilis)、蜡样芽孢杆菌(Bacillus cereus)、地衣芽孢杆菌(Bacillus licheniformis)、凝结芽孢杆
菌(Bacillus coagulans
梭菌属 酪酸梭菌(Clostridium butyricum
酵母菌属 布拉酵母菌(Saccharomyces boulardii

Tab 2

Totally or partially proven probiotic activity and mode of action on oral infectious diseases"

菌种或菌属名称 作用机制或应用领域
唾液链球菌K12 拮抗口腔病原菌[19]
罗伊氏乳杆菌 抑制口腔病原菌黏附[20]
Lactobacillus reuteri
唾液链球菌M18 作用于口腔黏膜上皮[21]
嗜酸乳杆菌LA-5 阻碍生物膜形成[21]
干酪乳杆菌LC-11 阻碍致龋生物膜形成[22,23]
副干酪乳杆菌 龋病治疗[23]
乳杆菌属 牙周病治疗[23]
双歧杆菌属 牙龈炎治疗[24]
鼠李糖乳杆菌 免疫调节[25]
乳双歧杆菌 提高对口腔感染的抵抗力[26]
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