Int J Stomatol ›› 2020, Vol. 47 ›› Issue (2): 131-137.doi: 10.7518/gjkq.2020034

• Periodontitis • Previous Articles     Next Articles

Application of probiotic ecological regulation in prevention and treatment of periodontal diseases

Liu Lin,Zhou Jieyu,Wu Yafei,Zhao Lei()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Periodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2019-07-14 Revised:2019-12-06 Online:2020-03-01 Published:2020-03-12
  • Contact: Lei Zhao
  • Supported by:
    This study was supported by National Natural Science Foundation of China(81371150);This study was supported by National Natural Science Foundation of China(81771077);Key Research and Development Project of Sichuan Province(2018SZ0161)


The initiating factor of periodontal diseases is plaque biofilm. In recent years, plaque hypothesis becomes increasingly inclined to the disruption of microbial homeostasis. Classic treatment method is mechanical plaque removal. However, individual differences exist in the curative effect, and some patients need to be assisted with other treatment methods. The role of probiotics in reconstructing host microbial community and regulating immune inflammatory responses may result in certain improvement in the microecology of periodontal diseases. This review summarises the clinical effects, mechanism and clinical application of probiotics for prevention and treatment of periodontitis, gingivitis, oral malodour and periimplant diseases from the perspective of the classification of periodontal diseases.

Key words: periodontal diseases, probiotics, clinical effect, mechanism, clinical application

CLC Number: 

  • R781.4

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