Int J Stomatol

Int J Stomatol ›› 2019, Vol. 46 ›› Issue (5): 585-592.doi: 10.7518/gjkq.2019068

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Research progress on second primary carcinoma of head and neck squamous cell carcinoma

Hao Fu1,Sun Rui1,2()   

  1. 1. Dept. of Oral and Maxillofacial Surgery, School and Hospital of Stomatology, Shanxi Medical University, Taiyuan 030001, China
    2. Dept. of Oral and Maxillofacial Surgery, Shanxi Provincial People’s Hospital, Taiyuan 030012, China
  • Received:2018-12-26 Revised:2019-03-29 Online:2019-09-01 Published:2019-09-10
  • Contact: Rui Sun E-mail:ruidoctor@163.com
  • Supported by:
    This study was supported by Program for Science Foundation of Shanxi Province(2011011037-2)

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Abstract:

Head and neck squamous cell carcinoma (HNSCC) is a common lethal disease, in which the formation of postoperative second primary carcinoma (SPC) mainly causes the decline of long-term survival rate. The occurrence of SPC is related to smoking, alcohol consumption, betel nut chewing, and other risk factors. Furthermore, SPC also involves the abnormal expression of related proteins and increase in genetic susceptibility caused by genetic polymorphisms in carcinogen metabolism, DNA repair, cell cycle, and apoptosis. Therefore, mastering the risk factors and molecular mechanisms of SPC is highly important in screening high-risk populations of SPC and in protocol development.

Key words: head and neck squamous cell carcinoma, second primary carcinoma, risk factor, molecular mechanism

CLC Number: 

  • R739.81

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