Int J Stomatol ›› 2024, Vol. 51 ›› Issue (1): 91-98.doi: 10.7518/gjkq.2024003

• Reviews • Previous Articles     Next Articles

Research progress on the risk factors of orthodontically induced enamel demineralization

Wang Nannan1(),He Hong1,Hua Fang1,2,3()   

  1. 1.State Key Laboratory of Oral & Maxillofacial Reconstruction and Regeneration, Key Laboratory of Oral Biomedicine Ministry of Education, Hubei Key Laboratory of Stomatology, School & Hospital of Stomatology, Wuhan University, Wuhan 430079, China
    2.Center for Orthodontics and Pediatric Dentistry at Optics Valley Branch, Hospital of Stomatology, Wuhan University, Wuhan 430079, China
    3.Center for Evidence-based Stomatology, Hospital of Stomatology, Wuhan University, Wuhan 430079, China
  • Received:2023-03-01 Revised:2023-07-21 Online:2024-01-01 Published:2024-01-10
  • Contact: Fang Hua;
  • Supported by:
    National Natural Science Foundation of China(81901044);Chinese Stomatological Association COS Basic Research Fund(COS-B2021-08)


During orthodontic treatment, the existence of orthodontic appliances and residual adhesives, as well as the resultant difficulty in oral hygiene, can lead to enamel demineralization, which is one of the most common side effects of orthodontics. Orthodontic enamel demineralization is often manifested as chalky spots on the labial surface of teeth, which can not only negatively affect dental appearance and reduce orthodontic patients’ satisfaction but also result in ca-ries and jeopardize oral health in severe cases. Improving our understanding of enamel demineralization’s risk factors and phenotypic characteristics is crucial to promote precise prevention and control of orthodontic enamel demineralization. This review aims to summarize the recent literature regarding risk factors of orthodontic enamel demineralization. It focuses on the association between orthodontic enamel demineralization and tooth position, oral hygiene, dietary habits, treatment time, type of appliances, changes in microflora, and 6-n-propylthiouracil individual taste sensitivity.

Key words: orthodontic treatment, enamel demine-ralization, risk factor, precision medicine

CLC Number: 

  • R783.5


Tab 1

The risk factors of orthodontically induced enamel demineralization"

酸蚀时间酸蚀时间≥15 s,釉质脱矿风险↑病例-对照研究[31]138
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