Int J Stomatol

Int J Stomatol ›› 2020, Vol. 47 ›› Issue (4): 478-483.doi: 10.7518/gjkq.2020071

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Research progress on macrophage polarization involved in the regulation of orthodontic tooth movement

Zhao Yujie1,Guan Xiaoyan1,2,Li Xiaolan3,Chen Qijun1,2,Wang Qian3,Liu Jianguo1,3()   

  1. 1. School of Stomatology, Zunyi Medical University, Zunyi 563006, China
    2. Dept. of Orthodontics, Hospital of Stomatology, Zunyi Medical University, Zunyi 563099, China
    3. The Special Key Laboratory of Oral Diseases Research, Institution of Higher Education in Guizhou Province, Zunyi 563006, China
  • Received:2019-10-14 Revised:2020-02-13 Online:2020-07-01 Published:2020-07-10
  • Contact: Jianguo Liu E-mail:13087891001@163.com
  • Supported by:
    This study was supported by Program for the Key Discipline Construction Project of Guizhou Province. Guizhou Degree Word ZDXK [2017] No. 5;Provincial and Municipal Science and Technology Cooperation Special Fund Project. Province and City Branch [2014] No. 41;Expert Workstation Construction Project of Zunyi Science and Technology Bureau. Zunyi City Branch [2016] No. 18

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Abstract:

Teeth move under orthodontic force. The plasticity of jawbone, compressive resistance of cementum, and stability of periodontal membrane environment are the biological bases of orthodontic periodontal tissue reconstruction and tooth movement. Orthodontic force on teeth affects the local periodontal microenvironment, which promotes macrophage polarization. In M1-type macrophages, the orthodontic tooth movement (OTM) secretion of inflammatory factors is conducive to alveolar bone absorption and subsequent OTM. M2-type macrophages play an anti-inflammatory role and promote the repair of periodontal tissues. This article reviews the role of M1-type and M2-type macrophages in OTM and the factors that influence macrophage polarization in orthodontic treatment. This article aims to provide theoretical basis for future research on macrophages in the orthodontic field and to accelerate OTM.

Key words: macrophage polarization, orthodontic tooth movement, root resorption, orthodontic treatment

CLC Number: 

  • R783.5

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Fig 1

The biological mechanism of macrophages involved in OTM"

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