Int J Stomatol ›› 2019, Vol. 46 ›› Issue (6): 730-734.doi: 10.7518/gjkq.2019090

• Reviews • Previous Articles     Next Articles

Effects of systemic and local factors on microbial homeostasis around implants

Huang Xiaoyu,Li Mingyun,Zhou Xue- dong,Cheng Lei()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Operative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2019-02-05 Revised:2019-06-20 Online:2019-11-01 Published:2019-11-14
  • Contact: Lei Cheng
  • Supported by:
    This study was supported by the 13th Five-year Plan of National Key Research and Development Program of China(2016YFC1102700)


Dental implantation is a routine treatment for tooth loss. With the increasing number of cases of planting failure, the main factor, peri-implantitis, has become the focus of experts and scholars. We recently found that certain systemic and local factors, such as smoking, drinking, diabetes, periodontitis, estrogen deficiency, oral hygiene, and cemented prostheses, may be involved in the occurrence, development, and prognosis of this disease. The Human Microbiome Project and other metagenomic projects worldwide have advanced our knowledge of the human oral microbiota, and the focus on the microbiology change of implants has gradually increased. We aimed to determine the influence of oral microbiota on the occurrence, development, and prognosis of peri-implant diseases by reviewing the recent research progress on peri-implant disease-related oral and systemic diseases.

Key words: peri-implant disease, oral microbiota, microbiological mechanism, systemic and local factor

CLC Number: 

  • R783.4

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