Int J Stomatol

Int J Stomatol ›› 2020, Vol. 47 ›› Issue (5): 616-620.doi: 10.7518/gjkq.2020052

• Reviews • Previous Articles    

Advances in the mechanism and effect of nicotine on alveolar osteoclasts

Yang Peipei(),Yang Yuchen,Zhang Qiang()   

  1. Dept. of Oral and Maxillofacial Surgery, First Affiliated Hospital of Nanchang University, Nanchang 330006, China
  • Received:2019-11-01 Revised:2020-04-26 Online:2020-09-01 Published:2020-09-16
  • Contact: Qiang Zhang E-mail:978566228@qq.com;zhq100@aliyun.com
  • Supported by:
    National Natural Science Foundation of China(81560189);National Natural Science Foundation of China(81260169)

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Abstract:

Smoking can promote periodontal disease. As one of the toxic chemicals in tobacco, nicotine is an important cause of periodontal diseases, including gingival bleeding, periodontal pocket formation, alveolar bone absorption and tooth loosening. Alveolar bone resorption results from the disrupted dynamic balance of bone tissue, which refers to the imbalance of bone resorption regulated by osteoblasts and osteoclasts. The special effect of nicotine on bone metabolism was clarified by studying the regulatory effect of nicotine on osteoclasts and inducing factors. The inducing effect of nicotine on the development of periodontal disease was further analysed. This article reviewed the research progress on the effect of nicotine on osteoclasts.

Key words: nicotine, osteoclasts, regulatory mechanism

CLC Number: 

  • R781.4

TrendMD: 
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