Int J Stomatol

Inter J Stomatol ›› 2015, Vol. 42 ›› Issue (2): 231-236.doi: 10.7518/gjkq.2015.02.026

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Platelet-rich fibrin and other biological materials used jointly for periodontal tissue repair

Guo Tianqi, Zhou Yanmin, Zhao Jinghui, Chu Shunli, Sun Qianyue, Luo Wenjing, Ma Shanshan   

  1. Dept. of Implant Center, Hospital of Stomatology, Jilin University, Changchun 130021, China
  • Received:2014-01-22 Revised:2014-09-09 Online:2015-03-01 Published:2015-03-01

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Abstract:

Platelet-rich fibrin(PRF) is derived from autologous blood without adding heterology or artificial agents. PRF presents a special microstructure that provides a compatible substrate for cell proliferation and migration. PRF also contains various cytokines that can promote healing and regeneration of damaged tissues. The feasibility of applying PRF as a biological scaffold to repair periodontal tissues and combining it with other biomaterials to refine repairing effect has been investigated by many researchers. The mechanism of PRF in promoting tissue regeneration has been further studied. This paper presents a review of studies on the application of PRF combined with other biological materials in periodontal tissue repair and the molecular mechanism of PRF in promoting tissue regeneration. However, the mechanisms of PRF in promoting tissue regeneration must be further elucidated.

Key words: platelet-rich-fibrin, tissue regeneration, cytokines, biological scaffold


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