Int J Stomatol

Inter J Stomatol ›› 2018, Vol. 45 ›› Issue (5): 553-559.doi: 10.7518/gjkq.2018.05.010

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Role of transforming growth factor-β in periodontitis

Jiangxue Tian,Longyi Mo,Xiaoyue Jia,Chengcheng Liu,Xin. Xu()   

  1. State Key Laboratory of Oral Diseases & National Clinical Research Center for Oral Diseases & Dept. of Conservative Dentistry and Endodontics, West China Hospital of Stomatology, Sichuan University, Chengdu 610041, China
  • Received:2017-12-31 Revised:2018-05-28 Online:2018-09-01 Published:2018-09-20
  • Contact: Xin. Xu E-mail:xin.xu@scu.edu.cn
  • Supported by:
    This study was supported by Natural Science Foundation of China(81430011);Young Teachers’ Scientific Research Start Foundation of Sichuan University(2016SCU11056)

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Abstract:

Growth factor is the basic regulator of tissue repair and plays an important role in periodontal tissue regeneration. Transforming growth factor-β (TGF-β) is a peptide that can regulate cell growth and differentiation. TGF-β has played an important role in the occurrence and development of periodontitis in previous studies. Thus, regulation of TGF-β expression may alleviate the symptoms of periodontitis and promote the regeneration of periodontal tissue, which might provide new ideas for the treatment of periodontitis. Research progress in this field is reviewed in the paper.

Key words: transforming growth factor-β, periodontitis, inflammatory bone resorption, tissue regeneration

CLC Number: 

  • R781.4 +2

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